Konrad Teodor Sawicki

Lutikizumab in Adults With Moderate to Severe Hidradenitis Suppurativa After Anti-TNF Therapy Failure

Alexa B. Kimball, Konrad Teodor Sawicki, Lindsay S. Ackerman, Hermenio Lima et autres

Importance: Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease with limited therapeutic options. Objective: To assess the efficacy and safety of lutikizumab, a dual-variable domain interleukin 1α/1β antagonist, for adult participants with moderate to severe HS who experienced anti-tumor necrosis factor …

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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

Konrad Teodor Sawicki, Hongyan Ning, Norrina B. Allen, Mercedes R. Carnethon et autres

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Metabolic liability for weight gain in early adulthood

Venkatesh Locharla Murthy, Jonathan D. Mosley, Andrew Perry, David R. Jacobs et autres

While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single "snapshots" of body mass index (BMI) to guide genetic and molecular discovery. Here, we study >2,000 young adults with metabolomics and proteomics to identify …

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Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Keenan S. Fine, John T. Wilkins, Konrad Teodor Sawicki

Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart …

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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

Niall J. Lennon, Leah Claire Kottyan, Christopher Kachulis, Noura S. Abul‐Husn et autres

Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to …

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Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

Niall J. Lennon, Leah Claire Kottyan, Christopher Kachulis, Noura S. Abul‐Husn et autres

Polygenic risk scores (PRS) have improved in predictive performance supporting their use in clinical practice. Reduced predictive performance of PRS in diverse populations can exacerbate existing health disparities. The NHGRI-funded eMERGE Network is returning a PRS-based genome-informed risk assessment to 25,000 diverse …

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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life

Konrad Teodor Sawicki, Hongyan Ning, Norrina B. Allen, Mercedes R. Carnethon et autres

BACKGROUNDElevated circulating branched chain amino acids (BCAAs), measured at a single time point in middle life, are strongly associated with an increased risk of developing type 2 diabetes mellitus (DM). However, the longitudinal patterns of change in BCAAs through young adulthood and …

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Clinical Metabolomic Landscape of Cardiovascular Physiology and Disease

Keenan S. Fine, John T. Wilkins, Konrad Teodor Sawicki

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Abstract P200: Cumulative Circulating Branched Chain Amino Acid Exposure in Young Adulthood and Incident Atherosclerotic Cardiovascular Disease (ASCVD) in Later Life: The CARDIA Study

Konrad Teodor Sawicki, Hongyan Ning, Keenan Fine, James Dorian Otvos et autres

Introduction: Circulating branched chain amino acid (BCAA) levels are associated with the development of diabetes mellitus (DM) and downstream ASCVD in middle-aged women. It is unknown if BCAAs in young adult men and women are associated with ASCVD events. BCAA levels may …

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Abstract P453: Apolipoprotein B, Low-Density Lipoprotein Particle Number, Non-High-Denisity Lipoprotein Cholesterol, Low-Density Lipoprotein Cholesterol, and Total Cholesterol for Atherosclerotic Cardiovascular Disease Risk Prediction in Young Adults

John T. Wilkins, Hongyan Ning, Konrad Teodor Sawicki, Allan D. Sniderman et autres

Introduction: Measures of atherogenic particle number (apoB and LDL particle number [LDL-P]) are stronger predictors of atherosclerotic cardiovascular disease (ASCVD) risk than measures of cholesterol concentration (LDL-C, non-HDL-C, total cholesterol [TC]) in middle-aged adults. It is unclear if this is true for …

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Abstract P594: High-Density Lipoprotein Particle Concentrations and Long-Term Atherosclerotic Disease Risk in Young Adults

John T. Wilkins, Waleed Alruwaili, Hongyan Ning, Konrad Teodor Sawicki et autres

Introduction: HDL particles vary in size and concentration. Indices of overall HDL particle concentration (HDL-P) and the concentrations of different HDL size subspecies (small: H1-H3, medium: H4, H5, and large: H6, H7) have differential associations with near-term CVD events in middle-aged adults. …

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Iron Metabolism in Cardiovascular Disease: Physiology, Mechanisms, and Therapeutic Targets

Konrad Teodor Sawicki, Adam De Jesus, Hossein Ardehali

The cardiovascular system requires iron to maintain its high energy demands and metabolic activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and enzyme activity. However, excess iron is also cardiotoxic due to its ability to catalyze the …

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