Robert C. Ladner

Data from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Abstract Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading …

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Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Data from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Abstract Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading …

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

Jon A. Kenniston, Ryan Faucette, Diana Martik, Stephen R. Comeau et autres

Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly regulated in healthy individuals by the serpin C1-inhibitor, but individuals with hereditary angioedema (HAE) are deficient in C1-inhibitor and …

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Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.4 Angstrom resolution

Thomas E. Edwards, Matthew C. Clifton, Jan A. Abendroth, Andrew E. Nixon et autres

Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution

Thomas E. Edwards, Matthew C. Clifton, Jan A. Abendroth, Andrew E. Nixon et autres

Drugs derived from phage display

Andrew E. Nixon, Daniel J. Sexton, Robert C. Ladner

Phage display, one of today’s fundamental drug discovery technologies, allows identification of a broad range of biological drugs, including peptides, antibodies and other proteins, with the ability to tailor critical characteristics such as potency, specificity and cross-species binding. Further, unlike in vivo …

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Discovery and Characterization Of a Highly Specific Antibody Inhibitor Of Plasma Kallikrein

Jon A. Kenniston, Daniel J. Sexton, Diana Martik, Ryan Faucette et autres

Abstract The plasma-kallikrein kinin (contact) system contributes to the physiological and pathophysiological reactions of vascular biology. Activation of this pathway causes the release of the potent nonapeptide vasodilator bradykinin following proteolytic cleavage of high-molecular weight kininogen (HMWK) by the serine protease plasma …

Discovery and Characterization of a Fully Human Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Treatment of Plasma Kallikrein-Mediated Edema

Daniel L. Sexton, Ryan Faucette, Malini Viswanathan, Niksa Kastrapeli et autres