Accès ouvert
2026
article
OpenAlex
Yvonne M. Mueller, Charlotte Girard, Harmen J G van de Werken, Stefan J. Erkeland et autres
OBJECTIVE: The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult-onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that …
nl, ch, fr, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Martijn W. C. Verbeek, Mathijs A. Sanders, Dwin G.B. Grashof, Remco M. Hoogenboezem et autres
Small nucleolar ribonucleic acids (snoRNAs) are a class of small non-coding RNAs involved in the post-transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B-cell precursor …
nl
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Martijn W. C. Verbeek, Mathijs A. Sanders, Dwin G.B. Grashof, Harmen J.G. van de Werken et autres
Background: B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) is characterized by the rapid proliferation of B-cell precursors in the bone marrow (BM). Despite successful treatment of pediatric BCP-ALL (treatment success rate >90%), adult BCP-ALL still has a dismal prognosis, with limited treatment options …
nl
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Christiaan J. Stavast, Iris van Zuijen, Stefan J. Erkeland
Mounting data show that MIR139 is commonly silenced in solid cancer and hematological malignancies. MIR139 acts as a critical tumor suppressor by tuning the cellular response to different types of stress, including DNA damage, and by repressing oncogenic signaling pathways. Recently, novel …
nl
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Christiaan J. Stavast, Iris van Zuijen, Elena Karkoulia, Arman Özçelik et autres
MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML). However, the tumor-suppressing activities of miR-139 and molecular mechanisms of MIR139-silencing remain largely unknown. Here, we studied the poorly prognostic MLL-AF9 fusion protein-expressing AML. We show that MLL-AF9 …
nl, cz
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord‐Vermeulen, Giada Dal Collo et autres
T-cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of small- to medium-sized prolymphocytes with a mature post-thymic phenotype, high aggressiveness of the disease and poor prognosis. However, T-PLL is more heterogeneous with a wide range of clinical, morphological, and molecular …
nl, us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Maria Catalina Gomez‐Puerto, Iris van Zuijen, Chris Huang, Robert Szulcek et autres
Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure which almost invariably leads to right heart failure and premature death. More than 70% of familial PAH and 20% of idiopathic PAH patients carry heterozygous mutations in the …
nl, gb
(code pays fourni par la source)