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Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Supplementary Figure 1 Legend
Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Supplementary Figure 1 - Time to recurrence in stage I (blue), II (yellow), and III (black) patients with colorectal cancer.
Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Abstract Background: Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor suppressor controlling epithelial homeostasis through circuits canonically …
Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Supplementary Figure 1 - Time to recurrence in stage I (blue), II (yellow), and III (black) patients with colorectal cancer.
Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Supplementary Figure 1 Legend
Chantell Wilson, Jieru Egeria Lin, Peng Li, Adam Eugene Snook et autres
Abstract Background: Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor suppressor controlling epithelial homeostasis through circuits canonically …
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
List of Primers.
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 1: Cytoplasmic PTHrP protein levels are reduced in breast cancer cells relative to normal breast epithelial cells. Quantification of cytoplasmic PTHrP protein levels in a progression array of normal, DCIS, primary invasive breast cancer (grades 1-3; IDC1-3), and lymph node …
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 7: Schematic representation of structure of wildtype Stat5a and Stat5b, dominant-negative Stat5 (DN-Stat5) and constitutively-active Stat5 (CA-Stat5) proteins.
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 2: Positive correlation between nuclear PTHrP and nuclear pY-Stat5 protein levels across progression series of breast cancer. Scatterplot of nuclear PTHrP and nuclear pY-Stat5 protein levels in normal breast epithelia, ductal carcinoma in situ (DCIS), primary invasive breast cancer (IDC), …
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 6: Nuclear PTHrP and nuclear pY-Stat5 protein levels are strongly positively correlated independent of breast cancer subtype. Scatterplot of nuclear PTHrP protein levels against nuclear pY-Stat5 levels according to immunohistochemistry-based subtyping. Regression lines were fitted using robust MM-estimation illustrating strong …
Thai Hong Tran, Fransiscus E. Utama, Takahiro Sato, Amy R. Peck et autres
Supplementary Figure 5: Higher nuclear PTHrP protein levels are associated with lower grade and estrogen receptor-positive (ER+) breast cancer. Nuclear PTHrP protein levels are significantly higher in well-differentiated, grade 1 tumors compared to grade 3 tumors (A) and significantly higher in ER-positive …
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