Minna Turkkila

Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA—Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to RA

Malin C. Erlandsson, Minna Turkkila, Rille Pullerits, Maria I Bokarewa

Background: Arthralgia often predates development of rheumatoid arthritis (RA). A set of clinical joint symptoms assisting recognition of patients during their transition from arthralgia to RA, has been recently proposed. Aim: To combine clinical and serological markers aiming to improve recognition of …

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Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of Sweden

Malin C. Erlandsson, Minna Turkkila, Filip Siljehult, Rille Pullerits et autres

OBJECTIVES: The aim of this study was to validate the use of survivin for preclinical recognition of rheumatoid arthritis (RA) among patients with unexplained arthralgia. METHODS: Serum levels of survivin and the arthritis-specific autoantibodies RF and ACPA were measured in total of …

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IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis

Malin C. Erlandsson, Sofia Töyrä Silfverswärd, Mitra Nadali, Minna Turkkila et autres

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SAT0033 Smoking contributes to exhausted state of CD4+ T cells in rheumatoid arthritis

Caroline Wasén, Minna Turkkila, Malin C. Erlandsson, KM Andersson et autres

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Survivin in autoimmune diseases

Giacomo Gravina, Caroline Wasén, María-José García-Bonete, Minna Turkkila et autres

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08.29 Smoking contributes to exhaustion state of cd4+ t cells in rheumatoid arthritis

Caroline Wasén, Minna Turkkila, Malin C. Erlandsson, Karin M Andersson et autres

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Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis

Caroline Wasén, Minna Turkkila, Apostolos Bossios, Malin C. Erlandsson et autres

CD8+ T cells have an emerging role in RA. Resent research indicates a causal relationship between the non-exhausted state of CD8+ T cells, defined by lost function of PD-1, and development of arthritis. We investigated how smoking contributes to the non-exhausted phenotype …

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Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis

Karin M Andersson, Minna Turkkila, Malin C. Erlandsson, Apostolos Bossios et autres

MicroRNAs (miRs) represent a part of epigenetic control of autoimmunity gaining increasing attention in rheumatoid arthritis (RA). Since cigarette smoking plays important role in RA pathogenesis and reprograms transcriptional profile of miRNAs, we ask if the onco-protein survivin, a novel biomarker of …

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Patient information sheets

Eric W.F.W. Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield et autres

Safety and adverse events

Eric W.F.W. Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield et autres

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Eric W.F.W. Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield et autres

Background Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual respiratory failure. With the exception of the small-molecule potentiator, …

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Cystic Fibrosis Questionnaire – Revised quality-of-life questionnaire

Eric W.F.W. Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield et autres