Mark Cadena

Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation

Petra Popovics, Asha Jain, Kegan O. Skalitzky, Elise Schroeder et autres

Fibrogenic and inflammatory processes in the prostate are linked to the development of lower urinary tract symptoms (LUTS) in men. Our previous studies identified that osteopontin (OPN), a pro-fibrotic cytokine, is abundant in the prostate of men with LUTS, and its secretion …

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PD11-04 LOSS OF OSTEOPONTIN LEADS TO THE RESOLUTION OF E. COLI-INDUCED PROSTATIC INFLAMMATION AND FIBROSIS

Petra Popovics, Asha Jain, Francesca Van, Hannah Ruetten et autres

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology (PD11)1 Sep 2021PD11-04 LOSS OF OSTEOPONTIN LEADS TO THE RESOLUTION OF E. COLI-INDUCED PROSTATIC INFLAMMATION AND FIBROSIS Petra Popovics, Asha Jain, Francesca Van, Hannah Ruetten, Mark Cadena, Kristen S. Uchtmann, Chad …

Osteopontin deficiency leads to the resolution of prostatic fibrosis and inflammation

Petra Popovics, Asha Jain, Kegan O. Skalitzky, Elise Schroeder et autres

ABSTRACT Fibrogenic and inflammatory processes in the prostate are linked to the development of lower urinary tract symptoms (LUTS) in men. Our previous studies identified that osteopontin (OPN), a pro-fibrotic cytokine, is abundant in the prostate of men with LUTS and its …

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A uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate

Hannah Ruetten, Jaskiran Sandhu, Brett Mueller, Peiqing Wang et autres

Bacterial infection is one known etiology of prostatic inflammation. Prostatic inflammation is associated with prostatic collagen accumulation and both are linked to progressive lower urinary tract symptoms in men. We characterized a model of prostatic inflammation using transurethral instillations of Escherichia coli …

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A Uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate

Hannah Ruetten, Jaskiran Sandhu, Brett Mueller, Peiqing Wang et autres

ABSTRACT Bacterial infection is one known etiology of prostatic inflammation. Prostatic inflammation is associated with prostatic collagen accumulation and both are linked to progressive lower urinary tract symptoms in men. We characterized a model of prostatic inflammation utilizing transurethral instillations of E. …

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Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate

Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal et autres

BACKGROUND: Castration-insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region based on facultative assays. Functional characterization of prostate epithelial populations isolated with individual cell surface markers has failed to provide a consensus on …

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Urethral luminal epithelia are castration-insensitive progenitors of the proximal prostate

Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal et autres

Abstract Castration-insensitive epithelial progenitors capable of regenerating the prostate are concentrated in the proximal region close to the urethra, but the identification of these cells has been limited to individual cell surface markers. Here, we use single cell RNA sequencing (scRNA-seq) to …

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Castration-Insensitive Luminal Cells of the Proximal Prostate are Urethral in Origin

Diya B. Joseph, Gervaise H. Henry, Alicia Malewska, Nida S. Iqbal et autres

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A temporal and spatial map of axons in developing mouse prostate

Anne E. Turco, Mark Cadena, Helen L. Zhang, Jaskiran Sandhu et autres

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NBCe1 in the Kidney and Lower Urogenital Tract

Phinea Z Romero, Heather L. Holmes, Mark Cadena, Simon J. Gibbons et autres

NBCe1 is an electrogenic Na + bicarbonate cotransporter expressed as three isoforms. NBCe1A is mainly found in the kidney (100% activity), NBCe1B is a general isoform (~25% activity), and NBCe1C is found in the nervous system (20% activity). This project was to …

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An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections

Kyle A. Wegner, Mark Cadena, Ryan L. Trevena, Anne E. Turco et autres

Though many methods can be used to identify cell types contained in complex tissues, most require cell disaggregation and destroy information about where cells reside in relation to their microenvironment. Here, we describe a polytomous key for cell type identification in intact …

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The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

Rachel J. Fenske, Mark Cadena, Quincy Eckert Harenda, Haley Wienkes et autres

The a-subunit of the heterotrimeric G z protein, Ga z , promotes b-cell death and inhibits b-cell replication when pancreatic islets are challenged by stressors.Thus, we hypothesized that loss of Ga z protein would preserve functional b-cell mass in the nonobese diabetic …

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