Bastien Léger

Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis

Agnès Ostertag, Bastien Léger, Eugénie Koumakis, Patrice Fardellone et autres

Early-onset osteoporosis (EOOP) is a rare form of primary osteoporosis defined by major skeletal fractures or low BMD that occurs in early age. However, the characteristics of the extracellular matrix that may contribute to bone fragility are unknown. We explored the microarchitecture …

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Les auteurs

Thomas Bardin, Martine Cohen‐Solal, Philippe Dieudé, Thomas Funck‐Brentano et autres

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Inadequate response to treatment reveals persistent osteoclast bone resorption in osteoporotic patients

Bastien Léger, Patrice Fardellone, Catherine Cormier, Agnès Ostertag et autres

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Bone analysis revealed high bone resorption in idiopathic osteoporosis in young adults

Bastien Léger, Agnès Ostertag, Thomas Funck‐Brentano, Caroline Marty et autres

Methods: Data from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, were analysed.Of the participants of the 3rd survey (2012-13, the baseline of the present study) with whole-spine radiography, 1,544 individuals (506 men and 1,038 women, mean age: …

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Persistence of fractures in bisphosphonate-treated patients reveals enhanced osteoclast number in trabecular bone despite low remodeling

Bastien Léger, Eugénie Koumakis, Caroline Marty, Patrice Fardellone et autres

Even 25 subjects (25,5%) with normal lumbar spine BMD had TBS˂1,23.Conclusions: TBS evaluation offers an additional information about bone metabolism in subjects with type 1 diabetes in advanced stages of diabetic nephropathy.TBS value is low in one third of patients and correlates …

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Persistence of Cloxagel HL 500 in mammary secretions during the dry period in dairy cows.

Makella Coudray, D. Champenois, Loïc Jouet, Bastien Léger et autres