Wei Yuan Cher

Panthera: a deep learning pan-genomic splice haplotypes identification tool

Wei Yuan Cher, Taniya Agarwal, Priscila Sun, Jin Rong Ow et autres

Individual genetic polymorphisms can exert a modifier effect on splicing. With about one single-nucleotide polymorphism per 250 bases, we hypothesized that consideration of splice haplotypes will improve the accuracy of spliceogenic variant annotation, as current methods mainly assess single DNA variants and …

sg, es (code pays fourni par la source)

Panthera: A Deep Learning Pan-genomic Splice Haplotypes Identification Tool

Wei Yuan Cher, Taniya Agarwal, Priscila Sun, Jin Rong Ow et autres

This repository contains the data required for the full functionality of Panthera: fasta: GRCh38 fasta sequence gtf: GRCh38 GTF from Gencode v47 reference_haplotypes: Haplotype background VCF of 35 individuals (pre-processed and original files from Ebert et al., 2021)

es, us (code pays fourni par la source)

Panthera: A Deep Learning Pan-genomic Splice Haplotypes Identification Tool

Wei Yuan Cher, Taniya Agarwal, Priscila Sun, Jin Rong Ow et autres

This repository contains the data required for the full functionality of Panthera: fasta: GRCh38 fasta sequence gtf: GRCh38 GTF from Gencode v47 reference_haplotypes: Haplotype background VCF of 35 individuals (pre-processed and original files from Ebert et al., 2021)

es, us (code pays fourni par la source)

Panthera: A Deep Learning Pan-genomic Splice Haplotypes Identification Tool

Wei Yuan Cher, Taniya Agarwal, Priscila Sun, Jin Rong Ow et autres

This repository contains the data required for the full functionality of Panthera: fasta: GRCh38 fasta sequence gtf: GRCh38 GTF from Gencode v47 reference_haplotypes: Haplotype background VCF of 35 individuals (pre-processed and original files from Ebert et al., 2021)

es, us (code pays fourni par la source)

Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform

Jin Rong Ow, Eri Imagawa, Feng Chen, Wei Yuan Cher et autres

sg, jp, sa, us, ru (code pays fourni par la source)

Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform

Tommaso Tabaglio, Taniya Agarwal, Wei Yuan Cher, Jin Rong Ow et autres

Chemical optimization of ribose has significantly advanced nucleic acid therapeutics (NATs) by improving the stability, specificity, and safety of therapies like small interfering RNAs, CRISPR-Cas9 guide RNAs, and GAPmers. Recent research has extended this approach to splice-switching oligonucleotides (SSOs), which target splicing …

sg, us (code pays fourni par la source)

Splice-switching oligonucleotides as therapeutics for citrin deficiency patients with a novel deep intronic variant

Kimihiko Oishi, Jin Rong Ow, Eri Imagawa, Wei Yuan Cher et autres

jp, sg, us (code pays fourni par la source)

Generating minimum set of gRNA to cover multiple targets in multiple genomes with MINORg

Rachelle R.Q. Lee, Wei Yuan Cher, Jinge Wang, Yujie Chen et autres

MINORg is an offline gRNA design tool that generates the smallest possible combination of gRNA capable of covering all desired targets in multiple non-reference genomes. As interest in pangenomic research grows, so does the workload required for large screens in multiple individuals. …

sg, cn (code pays fourni par la source)

Knock‐down of gene expression throughout meiosis and pollen formation by virus‐induced gene silencing in Arabidopsis thaliana

Vanesa Calvo‐Baltanás, Joke De Jaeger‐Braet, Wei Yuan Cher, Nils Schönbeck et autres

Through the inactivation of genes that act during meiosis it is possible to direct the genetic make-up of plants in subsequent generations and optimize breeding schemes. Offspring may show higher recombination of parental alleles resulting from elevated crossover (CO) incidence, or by …

de, sg, nl (code pays fourni par la source)

Generating minimum set of gRNA to cover multiple targets in multiple genomes with MINORg

Rachelle R.Q. Lee, Wei Yuan Cher, Eunyoung Chae

Abstract MINORg is an offline gRNA design tool that generates the smallest possible combination of gRNA capable of covering all desired targets in multiple non-reference genomes. As interest in pangenomic research grows, so does the workload required for large screens in multiple …

sg (code pays fourni par la source)

A Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana

A. Cristina Barragan, Maximilian Collenberg, Jinge Wang, Rachelle R.Q. Lee et autres

Hybrid necrosis in plants arises from conflict between divergent alleles of immunity genes contributed by different parents, resulting in autoimmunity. We investigate a severe hybrid necrosis case in Arabidopsis thaliana, where the hybrid does not develop past the cotyledon stage and dies …

de, sg (code pays fourni par la source)

A singleton NLR of recent origin causes hybrid necrosis in Arabidopsis thaliana

A. Cristina Barragan, Maximilian Collenberg, Jinge Wang, Rachelle R.Q. Lee et autres

Abstract Hybrid necrosis in plants arises from conflict between divergent alleles of immunity genes contributed by different parents, resulting in autoimmunity. We investigate a severe hybrid necrosis case in Arabidopsis thaliana , where the hybrid does not develop past the cotyledon stage …

de, sg (code pays fourni par la source)