Thiago Alves da Costa

B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells*

Roberta Pelanda, Sarah A. Greaves, Thiago Alves da Costa, Lena M. Cedrone et autres

Abstract The random recombination of immunoglobulin V(D)J gene segments produces unique IgM antibodies that serve as the antigen receptor for each developing B cell. Hence, the newly formed B cell repertoire is comprised of a variety of specificities that display a range …

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Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice

Thiago Alves da Costa, Jacob N. Peterson, Julie Lang, Jeremy Shulman et autres

Abstract Central B cell tolerance, the process responsible for mitigating the development of autoreactive B cells, has been extensively studied in mice, while little is known of how human B cells are tolerized in the bone marrow due to the inability to …

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Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice

Thiago Alves da Costa, Jacob N. Peterson, Julie Lang, Jeremy Shulman et autres

B cells undergo central tolerance, we discovered that human autoreactive immature B cells exhibit a distinctive phenotype that includes lower activation of ERK and differential expression of CD69, CD81, CXCR4, and other glycoproteins. Human B cells exhibiting these characteristics were observed in …

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The development of human immune system mice and their use to study tolerance and autoimmunity

Thiago Alves da Costa, Julie Lang, Raul M. Torres, Roberta Pelanda

Autoimmune diseases evolve from complex interactions between the immune system and self-antigens and involve several genetic attributes, environmental triggers and diverse cell types. Research using experimental mouse models has contributed key knowledge on the mechanisms that underlie these diseases in humans, but …

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Correction: Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis

Thiago Alves da Costa, Rosária Di Gangi, Rodolfo Thomé, Marina Barreto Felisbino et autres

[This corrects the article DOI: 10.1371/journal.pone.0164745.].

Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis

Thiago Alves da Costa, Rosária Di Gangi, Rodolfo Thomé, Marina Barreto Felisbino et autres

T cell maturation takes place within the thymus, a primary lymphoid organ that is commonly targeted during infections. Previous studies showed that acute infection with Paracoccidioides brasiliensis (Pb), the causative agent of paracoccidioidomycosis (PCM), promotes thymic atrophy that is associated with the …

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Inflamação e morte celular na atrofia tímica induzida pelo Paracoccidioides brasiliensis

Thiago Alves da Costa

Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs

Rosária Di Gangi, Thiago Alves da Costa, Rodolfo Thomé, Gabriela Peron et autres

BACKGROUND: Paracoccidioidomycosis, a chronic granulomatous fungal disease caused by Paracoccidioides brasiliensis yeast cells affects mainly rural workers, albeit recently cases in immunosuppressed individuals has been reported. Protective immune response against P. brasiliensis is dependent on the activity of helper T cells especially …

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Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Leukocyte Migration to the Central Nervous System

Rodolfo Thomé, Ana Carolina de Carvalho, Thiago Alves da Costa, Larissa Lumi Watanabe Ishikawa et autres

BACKGROUND AND AIMS: Experimental autoimmune encephalomyelitis (EAE) is T-cell-dependent disease of the central nervous system (CNS) of mice. This model resembles multiple sclerosis (MS) in many aspects. Therapies that focus in the modulation of the immune response and cellular infiltration in the …

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Differential Response of Human Hepatocyte Chromatin to HDAC Inhibitors as a Function of Microenvironmental Glucose Level

Marina Barreto Felisbino, Thiago Alves da Costa, Maria Sílvia Viccari Gatti, Maria Luiza S. Mello

Diabetes is a complex multifactorial disorder characterized by chronic hyperglycemia due to impaired insulin secretion. Recent observations suggest that the complexity of the disease cannot be entirely accounted for genetic predisposition and a compelling argument for an epigenetic component is rapidly emerging. …

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Efeitos dos produtos de radiolise da agua na crotamina (toxina do veneno de Crotalus durissus terrificus)

Thiago Alves da Costa, J.R. Rogero

Protection against Paracoccidioides brasiliensis infection in mice treated with modulated dendritic cells relies on inhibition of interleukin‐10 production by CD 8+ T cells

Thiago Alves da Costa, Rosária Di Gangi, Paula Martins, Ana Leda F. Longhini et autres

Paracoccidioidomycosis is a systemic infection prevalent in Latin American countries. Disease develops after inhalation of Paracoccidioides brasiliensis conidia followed by an improper immune activation by the host leucocytes. Dendritic cells (DCs) are antigen-presenting cells with the unique ability to direct the adaptive …

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