Accès ouvert
2026
preprint
OpenAlex
Murat Cokol, Lubomir Chorbadjiev, Yoon-ha Lee, Minal Jamsandekar et autres
Abstract Interpretation of genomic variants, positions, and regions depends on reliable annotation—adding evidence such as predicted effect, conservation, population frequency, and gene-level context—yet the underlying resources are numerous, versioned, and assembly-specific. We present the Genomic Annotation Infrastructure (GAIn), a platform that generates …
tr, bg, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Liubomir Chorbadjiev, Murat Cokol, Zohar Weinstein, Kevin Shi et autres
The exploration of genotypic variants impacting phenotypes is a cornerstone in genetics research. The emergence of vast collections containing deeply genotyped and phenotyped families has made it possible to pursue the search for variants associated with complex diseases. However, managing these large-scale …
bg, tr, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Liubomir Chorbadjiev, Murat Cokol, Zohar Weinstein, Kevin Shi et autres
Abstract The exploration of genotypic variants impacting phenotypes is a cornerstone in genetics research. The emergence of vast collections containing deeply genotyped and phenotyped families has made it possible to pursue the search for variants associated with complex diseases. However, managing these …
bg, us
(code pays fourni par la source)
Accès ouvert
2023
supplementary-materials
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplementary figure legends. Supplementary methods, including additional filtering and heuristics for sensitivity data processing and ACME analysis and additional methods for western blotting and immunostaining. Supplementary Table S8. Small molecules used in validation studies. Supplementary Table S9. CCLs used in the validation …
Accès ouvert
2023
supplementary-materials
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplemental Table S1. Small-molecule Informer Set Description of the small-molecule informer set used in the sensitivity profiling experiment, including protein target or activity. Supplemental Table S2.Cancer cell-line panel Description of the cancer cell lines profiled in this experiment; for a clarification of …
Accès ouvert
2023
other
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplemental Figure S1. Further characterization of the small-molecule Informer Set and comparisons between CTRP v1 and v2. Supplemental Figure S2. Cellular features of the CCL panel. Supplemental Figure S3. Details on ACME analysis described in this paper. Supplemental Figure S4. ACME identifies …
Accès ouvert
2023
other
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplemental Figure S1. Further characterization of the small-molecule Informer Set and comparisons between CTRP v1 and v2. Supplemental Figure S2. Cellular features of the CCL panel. Supplemental Figure S3. Details on ACME analysis described in this paper. Supplemental Figure S4. ACME identifies …
Accès ouvert
2023
supplementary-materials
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplemental Table S1. Small-molecule Informer Set Description of the small-molecule informer set used in the sensitivity profiling experiment, including protein target or activity. Supplemental Table S2.Cancer cell-line panel Description of the cancer cell lines profiled in this experiment; for a clarification of …
Accès ouvert
2023
supplementary-materials
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Supplementary figure legends. Supplementary methods, including additional filtering and heuristics for sensitivity data processing and ACME analysis and additional methods for western blotting and immunostaining. Supplementary Table S8. Small molecules used in validation studies. Supplementary Table S9. CCLs used in the validation …
Accès ouvert
2023
other
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Abstract Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between …
Accès ouvert
2023
other
OpenAlex
Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol et autres
Abstract Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between …
Accès ouvert
2022
article
OpenAlex
Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui et autres
Therapeutic options for treatment of basal-like breast cancers remain limited. Here, we demonstrate that bromodomain and extra-terminal (BET) inhibition induces an adaptive response leading to MCL1 protein-driven evasion of apoptosis in breast cancer cells. Consequently, co-targeting MCL1 and BET is highly synergistic …
us
(code pays fourni par la source)