Sayuri Tokioka

Cross-Sectional Study of the Association Between Housing Type Post-Great East Japan Earthquake and Liver Enzymes: Tohoku Medical Megabank Community-Based Cohort Study

Shigeru AIBA, N. Nakaya, Mana Kogure, Rieko Hatanaka et autres

The Great East Japan Earthquake significantly impacted Japanese residents’ lives and housing conditions. Housing type after a disaster may affect liver function; however, few studies have reported this association. This study analyzed the association between housing type after the Great East Japan …

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Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization

Rieko Hatanaka, Naoki Nakaya, Sayuri Tokioka, Ippei Chiba et autres

Background: In order to collect information on the onset of cardiovascular disease (CVD) events for participants, the Tohoku Medical Megabank Organization (ToMMo) constructed a system to identify CVD events using a self-administered questionnaire regarding CVD onset. The association between traditional cardiovascular risk …

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Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study

Chikashi Iwasaki, Kumi Nakaya, Mitsuhiro Yamada, Naoki Nakaya et autres

BACKGROUND: <80 %, is associated with increased morbidity and mortality. However, determinants of PRISm, particularly in younger populations, remain poorly characterised. We aimed to address this knowledge gap. METHODS: We conducted a cross-sectional analysis of 12,350 participants from a Japanese community-based cohort …

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Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study

Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya et autres

Antihypertensive therapy has reduced cardiovascular mortality; however, challenges remain, including residual risk in treated patients and the population burden associated with borderline hypertension. Previous Japanese estimates of the population attributable fraction (PAF) are derived from older cohorts and often lacked stratification by …

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Exploring risk factors for axial length elongation: a population-based cohort study of 9195 eyes in Japan

Hiroshi Kunikata, Naoko Takada, Makoto Ishikawa, Sayuri Tokioka et autres

PURPOSE: To investigate long-term axial length (AL) changes in adults and to identify risk factors contributing to excessive AL elongation, which is associated with high myopia, we analysed a large dataset of adults without ocular pathology from the Tohoku Medical Megabank Project …

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Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka et autres

ABSTRACT Background Whether adherence to a healthy lifestyle can mitigate genetic risk for renal dysfunction remains unclear. Methods This prospective cohort study included 12 680 adults aged ≥20 years, free from chronic kidney disease at baseline, enrolled in the Tohoku Medical Megabank …

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Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka et autres

BACKGROUND: No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM prevention strategies. METHODS: This prospective community-based …

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Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase, Takumi Hirata, Naoki Nakaya, Mana Kogure et autres

Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included …

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Concordance of Cancer Screening Attendance Among Spouse Couples: A Cross‐Sectional Survey of the Tohoku Medical Megabank Project

Naoki Nakaya, Kumi Nakaya, Toshimasa Sone, Mana Kogure et autres

OBJECTIVES: Owing to spousal pairs often exhibiting similar health behaviors, this study examined the concordance of cancer screening attendance between spouses using cross-sectional data from a large biobank study in Japan, which included 2022 spousal pairs. STUDY DESIGN: Cross-sectional study. METHODS: Self-administered …

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Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure et autres

Objectives: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including …

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Sex difference in genetic risk in the prevalence of atrial fibrillation

Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka et autres

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Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project

Naoki Nakaya, Kumi Nakaya, Mana Kogure, Yuka Kotozaki et autres

BACKGROUND: Natural disasters may have negative health effects on survivors. However, long-term observations on this are lacking. Therefore, this study investigated the association between the degree of housing damage caused by the Great East Japan Earthquake (GEJE) and all-cause mortality using the …

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