Zachary Montague

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

This dataset contains longitudinal T cell repertoire sequence information from 120 individuals with and without post-acute sequelae of COVID-19. Sampling captured 2 to 3 time points per individual, during and after acute infection with COVID-19. Additionally, this repository contains SoNNia and IGoR …

us, Afrique du Sud (code pays fourni par la source)

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

This dataset contains longitudinal T cell repertoire sequence information from 120 individuals with and without post-acute sequelae of COVID-19. Sampling captured 2 to 3 time points per individual, during and after acute infection with COVID-19. Additionally, this repository contains SoNNia and IGoR …

us, Afrique du Sud (code pays fourni par la source)

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological features that distinguish individuals who develop PASC from those who recover fully are unresolved, in part …

us, Afrique du Sud (code pays fourni par la source)

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

This dataset contains longitudinal T cell repertoire sequence information from 120 individuals with and without PASC. Sampling captured 2 to 3 time points per individual, during and after acute infection with COVID-19. The manuscript on this data can be accessed at:

us, Afrique du Sud (code pays fourni par la source)

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological features that distinguish individuals who develop PASC from those who recover fully are unresolved, in part …

T-cell repertoire response in individuals with post-acute sequelae of COVID-19

Zachary Montague, Rhea M Grover, Andrew Baumgartner, Assya Trofimov et autres

T-cells are central to SARS-CoV-2 clearance and immunological memory, yet their contribution to the persistence of post-acute sequelae of COVID-19 (PASC) remains poorly understood. The immunological features that distinguish individuals who develop PASC from those who recover fully are unresolved, in part …

Design principles of the cytotoxic CD8 + T cell response

Obinna Ukogu, Zachary Montague, Grégoire Altan‐Bonnet, Armita Nourmohammad

Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studies have cataloged many molecular and cellular actors involved in an immune response, the design principles governing how the speed and magnitude of T cell responses emerge …

us, cz, fr, Afrique du Sud, jp (code pays fourni par la source)

Genetic and environmental imprints on T cell receptor repertoires as predictors of graft-versus-host disease

Assya Trofimov, Zachary Montague, Magdalena L Russell, Rachel Bender Ignacio et autres

Abstract Hematopoietic cell transplantation (HCT) as potentially curative treatment for patients with hematologic malignancies relies on T cells to mediate the potentially curative graft-versus-tumor (GVT) effect, which may be associated with graft-versus-host disease (GVHD), a potentially life-threatening complication. T cells recognize peptides …

Afrique du Sud, us, ca (code pays fourni par la source)

Design principles of the cytotoxic CD8 + T-cell response

Obinna Ukogu, Zachary Montague, Grégoire Altan‐Bonnet, Armita Nourmohammad

Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studies have cataloged many molecular and cellular actors involved in an immune response, the design principles governing how the speed and magnitude of T-cell responses emerge from …

us (code pays fourni par la source)

Design principles of the cytotoxic CD8+ T-cell response

Obinna Ukogu, Zachary Montague, Grégoire Altan‐Bonnet, Armita Nourmohammad

Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studies have cataloged many molecular and cellular actors involved in an immune response, the design principles governing how the speed and magnitude of T-cell responses emerge from …

Adaptive efficiency of information processing in immune-pathogen co-evolution

Quinn Bellamy, Zachary Montague, Luca Peliti, Armita Nourmohammad

Organisms have evolved immune systems that can counter pathogenic threats. The adaptive immune system in vertebrates consists of a diverse repertoire of immune receptors that can dynamically reorganize to specifically target the ever-changing pathogenic landscape. Pathogens in return evolve to escape the …

us (code pays fourni par la source)

Adaptive efficiency of information processing in immune-pathogen co-evolution

Quinn Bellamy, Zachary Montague, Luca Peliti, Armita Nourmohammad

Organisms have evolved immune systems that can counter pathogenic threats. The adaptive immune system in vertebrates consists of a diverse repertoire of immune receptors that can dynamically reorganize to specifically target the ever-changing pathogenic landscape. Pathogens in return evolve to escape the …