Giorgia Chinigò

Rational Design of a Red-Light Absorbing dinuclear Ruthenium (II) Complex with Photodynamic potential

Julia D. Magdaleno, Giorgia Chinigò, Francesca Bianco, Stefano Scoditti et autres

Conventional chemotherapeutic agents often suffer from systemic toxicity, poor selectivity, and the emergence of drug resistance, highlighting the urgent need for alternative anticancer strategies. In this context, light-activated therapies have emerged as promising minimally invasive approaches for controlled cancer treatment. However, the …

Breast cancer extracellular vesicles transfer P2X7 signaling competence to endothelial cells and dynamically remodel vascular migration

Giorgia Chinigò, Giorgia Scarpellino, Oyku Yaman Hizdri, Elena SAVIO et autres

Communication between tumor cells and the vascular endothelium is a key determinant of tumor progression and angiogenesis. Purinergic signaling critically regulates endothelial migration, permeability, and vascular plasticity. Our previous findings showed that strong purinergic stimulation exerts anti-migratory and vessel-normalizing effects in tumor-derived …

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The pervasive negative regulation of ion channel functional families across human cancers

Luca Visentin, Luca Munaron, Paola Cassoni, Luca Bertero et autres

Abstract The transmembrane transport of molecules and ions is fundamental to cellular homeostasis and coordination of physiological processes. During tumorigenesis, these processes undergo significant alterations in response to oncogenic transformations and microenvironmental pressures. However, a comprehensive systems-level characterization of transportome alterations across …

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Intracellular calcium-induced ROS generation promotes squaraine phototoxicity

Giorgia Chinigò, Carlotta Pontremoli, Francesca Bianco, Alessandra Gilardino et autres

Photodynamic therapy (PDT) is a minimally invasive therapeutic modality approved by the Food and Drug Administration (FDA) for the treatment of several pathological conditions, including cancer. Developing new photosensitizers (PSs) for PDT is of great interest to increase the treatment efficacy while …

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Histamine 1 receptors and reverse-mode Na+/Ca2+ exchanger drive extracellular Na+-dependent intracellular Ca2+ oscillations in human cerebrovascular endothelial cells

Valentina Brunetti, Roberto Berra‐Romani, Nayeli Coyotl-Santiago, Yair Esquitin-Gonzalez et autres

Cerebrovascular endothelial cells represent the core component of the blood-brain barrier, (BBB) which plays a critical role in regulating the local ionic microenvironment around the synapses. Therefore, cerebrovascular endothelial cells experience dramatic changes in the extracellular concentrations of potassium and sodium ions …

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The potential of TRP channels as new prognostic and therapeutic targets against prostate cancer progression

Giorgia Chinigò, Federico Alessandro Ruffinatti, Luca Munaron

Prostate cancer (PCa) is the second deadliest cancer among men worldwide. Particularly critical is its development towards metastatic androgen-independent forms for which the current therapies are ineffective. Indeed, the 5-year relative survival for PCa drops dramatically to 34 % in the presence …

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Osteoblast Response to Widely Ranged Texturing Conditions Obtained through High Power Laser Beams on Ti Surfaces

Federico Alessandro Ruffinatti, Tullio Genova, Ilaria Roato, Martina Perin et autres

Titanium and titanium alloys are the prevailing dental implant materials owing to their favorable mechanical properties and biocompatibility, but how roughness dictates the biological response is still a matter of debate. In this study, laser texturing was used to generate eight paradigmatic …

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Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition

Mathilde Lebas, Giorgia Chinigò, Evan Courmont, Louay Bettaieb et autres

Endothelial cells (ECs) are highly plastic, capable of differentiating into various cell types. Endothelial-to-mesenchymal transition (EndMT) is crucial during embryonic development and contributes substantially to vascular dysfunction in many cardiovascular diseases (CVDs). While targeting EndMT holds therapeutic promise, understanding its mechanisms and …

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Modulation of purinergic signaling in endothelial cells by tumor microenvironment

Giorgia Chinigò, Giorgia Scarpellino, Sara Petrillo, Tullio Genova et autres

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Vacuum Plasma Treatment Device for Enhancing Fibroblast Activity on Machined and Rough Titanium Surfaces

Luigi Canullo, Tullio Genova, Giorgia Chinigò, Roberta Iacono et autres

This study was conducted to compare the effects of an innovative plasma surface treatment device that does not need a gas supply for titanium disks with two different surface topographies: the prototypical machined surface (MAC) and one of the most diffused roughened …

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The Emerging Concept of Transportome: State of the Art

Federico Alessandro Ruffinatti, Giorgia Scarpellino, Giorgia Chinigò, Luca Visentin et autres

The array of ion channels and transporters expressed in cell membranes, collectively referred to as the transportome, is a complex and multifunctional molecular machinery; in particular, at the plasma membrane level it finely tunes the exchange of biomolecules and ions, acting as …

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The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels

Luca Munaron, Giorgia Chinigò, Giorgia Scarpellino, Federico Alessandro Ruffinatti

Living organisms are multiscale complex systems that have evolved high degrees of multifunctionality and redundancy in the structure-function relationship. A number of factors, only in part determined genetically, affect the jobs of proteins. The overall structural organization confers unique molecular properties that …

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