Erin C. Davis

Maternal Perinatal Gut Microbiome Is Shaped by Traditional Farming Lifestyle and Associated With Early Childhood Atopic Disease

Erin C. Davis, Courtney M. Jackson, Nichole S. Diaz, Jazmine Susana et autres

Maternal exposure to a traditional farming lifestyle during pregnancy is associated with protection against allergic disease in childhood; however, the mechanism remains unclear. Pre-clinical work has demonstrated a role for the maternal gut microbiome in fetal immune programming. Given the diverse microbial …

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Can microbes in a baby’s gut prevent food allergies?

Kirsi M. Jarvinen-Seppo, Erin C. Davis

Can microbes in a baby's gut prevent food allergies?Food allergies are becoming increasingly common in children, yet scientists still do not fully understand why some infants develop allergies while others do not.At the University of Rochester in the US, Professor Kirsi Järvinen-Seppo …

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Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes

Kevin Bu, Tyler Scherzi, Adam Cantor, Andy Teng et autres

Background The sharp increase in prevalence of atopic disease suggests a role for environmental factors, such as the microbiome. Here, we study the impact of immunoglobulin A (IgA) coating of gut bacteria in infancy on allergic outcomes in two distinct populations: (1) …

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The enteric DNA virome differs in infants at risk for atopic disease

Tyrus Perdue, Cassandra E. Newkirk, Robert Beblavy, Antti E. Seppo et autres

Atopic disease prevalence, including atopic dermatitis, food allergy, asthma, and allergic rhinitis, has risen dramatically in industrialized countries. Traditional, single family farming lifestyles protect against atopic disease, but the mechanisms are incompletely understood. While there are established epidemiologic connections between childhood respiratory …

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Farm exposure in infancy is associated with elevated systemic IgG 4 , mucosal IgA responses, and lower incidence of food allergy

Courtney M. Jackson, Elizabeth Ponko, Natalie M. Vance, Erin C. Davis et autres

The role of antibodies in protection against food allergy is debated. Here, we designed a longitudinal birth cohort study recruiting participants from an Old Order Mennonite (OOM) community, a traditional farm lifestyle considered to be at low risk for allergic diseases, and …

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Opportunistic Cardiovascular Risk Screening in Women: Comparison With National Data and Implications for Early Prevention

Nasrin Sultana, S Y Tan, Erin C. Davis

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Vitamin D Deficiency and Cardiovascular Disease Risk Factors Among American Indian Adolescents: The Strong Heart Family Study

Jessica A. Reese, Erin C. Davis, Amanda M. Fretts, Tauqeer Ali et autres

Introduction: We aimed to describe the prevalence of vitamin D deficiency among American Indian adolescents and determine its association with cardiovascular disease (CVD) risk factors. Methods: Our study population consisted of 307 adolescents (aged ≤20 years) participating in the Strong Heart Family …

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Infant Microbiota Communities and Human Milk Oligosaccharide Supplementation Independently and Synergistically Shape Metabolite Production and Immune Responses in Healthy Mice

Patricia Tripp, Erin C. Davis, Manoj Gurung, Fernanda Trindade da Rosa et autres

BACKGROUND: Multiple studies have demonstrated associations between the early-life gut microbiome and incidence of inflammatory and autoimmune disease in childhood. Although microbial colonization is necessary for proper immune education, it is not well understood at a mechanistic level how specific communities of …

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Replanting the Birthing Trees to Support Aboriginal and Torres Strait Islander Parents and Babies: Protocol for developmental evaluation of a comprehensive culturally responsive, trauma-aware, healing-informed, continuity of care(r) model

Catherine Chamberlain, Jacqui Sundbery, Leonie Segal, Jacynta Krakouer et autres

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Abstract P427: Vitamin D Deficiency and Cardiovascular Disease (CVD) Risk Factors in American Indian Adolescents: The Strong Heart Family Study

Jessica A. Reese, Carson Willis, Erin C. Davis, Jennifer David Peck et autres

Introduction: Vitamin D deficiency (VDD) may be associated with CVD risk factors, such as obesity, diabetes, and dyslipidemia and is amenable to successful interventions through changes in diet and vitamin supplementation. Aims: To describe the prevalence of VDD among American Indian adolescents …

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Gut microbiome in the first 1000 days and risk for childhood food allergy

Erin C. Davis, Cynthia L. Monaco, Richard A. Insel, Kirsi M. Järvinen

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Sex‐specific biobehavioral regulation of persistent inflammatory pain by alcohol

Jessica A. Cucinello‐Ragland, Noor H. Alrashed, Sumin Lee, Erin C. Davis et autres

BACKGROUND: Although a large percentage of chronic pain patients consume alcohol to manage their pain, there is a significant gap in knowledge regarding the mechanisms underlying the antinociceptive effects of alcohol. METHODS: To determine the longitudinal analgesic effects of alcohol, we utilized …

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