Sandrine Eimer

Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation

Lucas Rincón de la Rosa, Noemie Barillot, Isaias Hernandez-Verdin, Roser Velasco et autres

Abstract Background Clinical scores incompletely capture outcomes in primary central nervous system lymphoma (PCNSL). We quantified morphologic heterogeneity in pretreatment hematoxylin and eosin (H&E) whole slides. Patients and methods Three independent cohorts of immunocompetent, HIV- and EBV-negative patients treated recently were analyzed: …

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Percutaneous Radiofrequency Ablation After Incomplete Adrenalectomy in a Lateralized Case of Primary Aldosteronism

Pierre-Antonin Rigon, Nicolas Villard, Karim Abid, Tobias Zingg et autres

Primary aldosteronism (PA) is a common cause of secondary hypertension. When unilateral aldosterone secretion is identified, surgery is the treatment of choice in most patients and is associated with a high cure rate. Alternative treatments, such as radiofrequency ablation (RFA), are possible …

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Descriptive epidemiology of 399 histologically confirmed newly diagnosed meningeal solitary fibrous tumours and haemangiopericytomas in France: 2006–2015

Charles Champeaux, Sonia Zouaoui, Amélie Darlix, Valérie Rigau et autres

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Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Charles Champeaux, Sonia Zouaoui, Amélie Darlix, Valérie Rigau et autres

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Molecular and clinical diversity in primary central nervous system lymphoma

Isaias Hernández-Verdín, E. Kirasic, Kirsty Wienand, Karima Mokhtari et autres

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare and distinct entity within diffuse large B-cell lymphoma presenting with variable response rates probably to underlying molecular heterogeneity. PATIENTS AND METHODS: To identify and characterize PCNSL heterogeneity and facilitate clinical translation, we …

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Molecular and clinical diversity in primary central nervous system lymphoma: a LOC Network study

Agustí Alentorn, Isaias Hernández-Verdín, Eva Kirasic, Kirsty Wienand et autres

Abstract Primary central nervous system lymphoma (PCNSL) is a distinct extranodal lymphoma presenting with limited stage disease but variable response rates to treatment despite homogenous pathological presentation. The likely underlying molecular heterogeneity and its clinical impact is poorly understood.We performed a comprehensive …

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Descriptive Epidemiology of Ependymal Tumors in Gironde, France: Results from the Gironde Registry for the 2000–2018 Period

G. Lainé, Isabelle Baldi, Vincent Jecko, Zamira Betancourt et autres

BACKGROUND: The Gironde Central Nervous System (CNS) Tumor Registry, in collaboration with the French National Cancer Institute, is the largest population-based registry focused exclusively on primary CNS tumors in France and represents a population of 1.62 million. This report focuses on ependymal …

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Supplementary Material for: Descriptive Epidemiology of Ependymal Tumors in Gironde, France: Results from the Gironde Registry for the 2000–2018 Period

G. Lainé, Isabelle Baldi, Vincent Jecko, Zamira Betancourt et autres

Background: The Gironde Central Nervous System (CNS) Tumor Registry, in collaboration with the French National Cancer Institute, is the largest population-based registry focused exclusively on primary CNS tumors in France and represents a population of 1.62 million. This report focuses on ependymal …

Characteristics of IDH-mutant gliomas with non-canonical IDH mutation

L. Poetsch, Charlotte Bronnimann, Hugues Loiseau, Jean-Sebastian Frenel et autres

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Pasireotide-LAR in acromegaly patients treated with a combination therapy: a real-life study

Hélène Lasolle, Amandine Ferrière, Alexandre Vasiljevic, Sandrine Eimer et autres

PURPOSE: Little data are available regarding the safety and efficacy of switching to Pasireotide-LAR monotherapy in acromegaly patients with partial resistance to first-generation somatostatin agonists (1gSRL) who require combination treatment with cabergoline or pegvisomant. METHOD: In this monocentric prospective study within a …

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Combining 3′-Deoxy-3′-[18F] fluorothymidine and MRI increases the sensitivity of glioma volume detection

Philippe Fernandez, Paolo Zanotti‐Fregonara, Sandrine Eimer, É. Gimbert et autres

OBJECTIVE: 3'-Deoxy-3'-[18F] fluorothymidine (18F-FLT) is a marker of cell proliferation and displays a high tumor-to-background ratio in brain tumor lesions. We determined whether combining 18F-FLT PET and MRI study improves the detection of tumoral tissue compared to MRI alone and whether 18F-FLT …

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P04.12 Characteristics of IDH-mutant gliomas with non-canonical IDH mutations

L. Poetsch, Caroline Dehais, Jean-Sebastian Frenel, Aurore Siegfried et autres

Abstract BACKGROUND About 10% of IDH-mutant gliomas harbor non-canonical IDH mutations (non-R132H IDH1 and IDH2 mutations). The aim of the present study was to analyze the characteristics of these gliomas in comparison to those of IDH1 R132H mutant gliomas. MATERIAL AND METHODS …

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