Runsang Pan

Correction: Ansofaxine hydrochloride inhibits tumor growth and enhances anti-TNFR2 in murine colon cancer model

Qianyu Jing, Quan Wan, Yujie Nie, Junqian Luo et autres

Colon cancer (CRC) is the fourth deadliest cancer worldwide, killing hundreds of thousands of people each year (1). At the same time, the mental health of patients is also attracting more and more attention, with the occurrence of depression in cancer patients …

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lncRNA FBXL19-AS1 Regulates Osteosarcoma Cell Proliferation, Migration and Invasion by Sponging miR-346 [Retraction]

Runsang Pan, Zhixu He, Wanyuan Ruan, Sun Li et autres

[This retracts the article DOI: 10.2147/OTT.S160963.].

BMSC-derived extracellular vesicles enhance osteosarcoma proliferation and metastasis via the circRNA-0010220/β-catenin pathway

Runsang Pan, Yujie Pan, Wanyuan Ruan, Hao Zheng et autres

Osteosarcoma (OS) remains a challenging malignancy with a high propensity for metastasis and poor survival outcomes. Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) have emerged as key mediators in the tumor microenvironment, promoting OS progression. This study identifies a novel molecular …

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Identification and detection of toxic substances involved in Gelsemium elegans Benth poisoning case

Zou Lu, 叶琳, WU Anzhong, Huang Junfei et autres

In this study, in response to a Gelsemium elegans Benth poisoning incident triggered by the consumption of homemade infused wine, the collected infused wine and the patient’s biological samples (blood and urine) were systematically examined using an integrated analytical strategy that combines …

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Anti-inflammatory effects of Lonicera macranthoides Hand.-Mazz based on Spectrum-effect relationship, network pharmacology and molecular docking technology

Wei Zhou, Huang Junfei, Runsang Pan, Qu Xingda et autres

This study investigated the anti-inflammatory properties of Lonicera macranthoides and its active component isochlorogenic acid C (ILAC) through an integrated approach combining spectrum-effect relationship analysis, network pharmacology, and molecular docking. Five extracts (S1-S5) were evaluated in LPS-stimulated RAW 264.7 macrophages, with S4 …

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124 I‐labelled BMSC‐Derived Extracellular Vesicles Deliver CRISPR/Cas9 Ribonucleoproteins With a GFP‐Reporter System to Inhibit Osteosarcoma Proliferation and Metastasis

Yujie Pan, Xianteng Yang, Zhirui Zeng, Futao Liu et autres

ABSTRACT Metastasis constitutes the principal factor leading to the unfavourable prognosis of osteosarcoma patients. Hypoxia, as the inherent microenvironment of osteosarcoma, can upregulate HIF‐1α via multiple pathways, thereby facilitating osteosarcoma proliferation and metastasis. Our previous research indicated that the inwardly rectifying potassium …

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Black phosphorus nanosheet hydrogels elicit a thermogenic effect and enhance diabetic wound healing through controlled drug release

Yangyang Li, Yujie Pan, Lingchao Kong, Jianxiang Teng et autres

• DFO-BP@Gel possesses the functions of sustained and controlled release. • DFO-BP@Gel has the ability to trigger a warming effect. • DFO-BP@Gel is capable of promoting angiogenesis, alleviating inflammatory responses and excessive ROS, and facilitating the healing of diabetic wounds. Diabetic wounds, …

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Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy

Yujie Pan, Yangyang Li, Xin Zhou, Jin Jun Luo et autres

The management of diabetic wounds faces significant challenges due to the excessive activation of reactive oxygen species (ROS), dysregulation of the inflammatory response, and impaired angiogenesis. A substantial body of evidence suggests that the aforementioned diverse factors contributing to the delayed healing …

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Black Phosphorus Nanosheet Hydrogels Elicit a Thermogenic Effect and Enhance Diabetic Wound Healing Through Controlled Drug Release

Yangyang Li, Yujie Pan, Lingchao Kong, Jianxiang Teng et autres

Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway

Zihao Zhao, Qihong Wu, Yangyang Xu, Yuhuan Qin et autres

. Animal experiments confirmed that groenlandicine combined with cisplatin suppressed OS growth with lower nephrotoxicity. Groenlandicine induces apoptosis and enhances the sensitivity of drug-resistant OS cells to cisplatin via the BAX/Bcl-2/Caspase-9/Caspase-3 pathway. Groenlandicine inhibits OS cells growth by down-regulating TOP1 level.Therefore, groenlandicine …

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Analysis of the effects of M 2 macrophage‐derived PDE 4 C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma

Feng Pan, Runsang Pan, Rui Hu, Hao Zhang et autres

Tumour-associated macrophages (TAMs), encompassing M1 and M2 subtypes, exert significant effects on osteosarcoma (OS) progression and immunosuppression. However, the impacts of TAM-derived biomarkers on the progression of OS remains limited. The GSE162454 profile was subjected to single-cell RNA (scRNA) sequencing analysis to …

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Comprehensive analysis of anoikis-related genes in diagnosis osteoarthritis: based on machine learning and single-cell RNA sequencing data

Jun-Song Zhang, Runsang Pan, Guolu Li, Jian-Xiang Teng et autres

Osteoarthritis (OA) is a degenerative disease closely associated with Anoikis. The objective of this work was to discover novel transcriptome-based anoikis-related biomarkers and pathways for OA progression.The microarray datasets GSE114007 and GSE89408 were downloaded using the Gene Expression Omnibus (GEO) database. A …

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