Ronald H. Böcker

Age Dependency of Rolitetracycline-Induced Hepatic Steatosis

C.‐J. Estler, Ronald H. Böcker

A comparative study on the effect of rolitetracycline (50 micrograms/g i.v.) on the hepatic content of triglycerides and the release of esterified fatty acids from the liver into the blood was performed in young and adult NMRI mice of both sexes. Rolitetracycline …

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Diagnostisches und therapeutisches Konzept bei CMD aus manualmedizinischer Sicht

Ulrich Christian Smolenski, Ronald H. Böcker, Norman Best

Die Behandlung von Patienten umfasst zunehmend funktionelle Aspekte. Das trifft auch auf Störungen des craniomandibulären Systems zu. Deshalb ist eine komplexe Betrachtungsweise notwendig. Hier sind neben Gelenk und Muskulatur auch Ansteuerung, Faszien und neuronale Verknüpfungen maßgebend. Manualmedizinisches Denken und Berücksichtigung von Verkettungen …

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Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes

M. Baumhäkel, Dirk Kasel, Rose Rao‐Schymanski, Ronald H. Böcker et autres

BACKGROUND: The human cytochrome P450 enzyme CYP3A4 is involved in the metabolism of many anticancer drugs. Since these drugs are usually administered in a polychemotherapy regimen, the objective of this study was to examine their inhibitory potency on CYP3A4 with regard to …

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Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase.

B Kleingeist, Ronald H. Böcker, Gerd Geißlinger, Roland Brugger

PURPOSE: In vivo the biotransformation of the imidazobenzodiazepine antagonist flumazenil leads to the formation of two metabolites, flumazenil acid and N-demethylated flumazenil. In the present study we investigated the role of carboxylesterases for the metabolism of flumazenil. METHODS: We purified a non-specific …

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Inhibitory Effects of Silibinin on Cytochrome P‐450 Enzymes in Human Liver Microsomes

Svane Beckmann‐Knopp, Stephan Rietbrock, Roland Weyhenmeyer, Ronald H. Böcker et autres

Silibinin, the main constituent of silymarin, a flavonoid drug from silybum marianum used in liver disease, was tested for inhibition of human cytochrome P-450 enzymes. Metabolic activities were determined in liver microsomes from two donors using selective substrates. With each substrate, incubations …

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Inhibitory Effects of Trospium Chloride on Cytochrome P450 Enzymes in Human Liver Microsomes

Svane Beckmann‐Knopp, Stephan Rietbrock, Roland Weyhenmeyer, Ronald H. Böcker et autres

Trospium chloride, an atropine derivative used for the treatment of urge incontinence, was tested for inhibitory effects on human cytochrome P450 enzymes. Metabolic activities were determined in liver microsomes from two donors using the following selective substrates: dextromethorphan (CYP2D6), denitronifedipine (CYP3A4), caffeine …

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Relationship between hepatic cytochrome P450 3A content and activity and the disposition of midazolam administered orally.

Christoph Wandel, Ronald H. Böcker, Hubert Bohrer, J Devries et autres

It was recently shown by others that the clearance of midazolam/kg body weight after iv administration correlates with hepatic cytochrome P450 (CYP or P450) 3A content in liver transplant patients. However, after po administration midazolam undergoes significant first-pass metabolism, with significant intestinal …

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Identification of Enzymes Involved in the Metabolism of Atrazine, Terbuthylazine, Ametryne, and Terbutryne in Human Liver Microsomes

Dieter H. Lang, Allan E. Rettie, Ronald H. Böcker

Compounds of the s-triazine family are among the most heavily used herbicides over the last 30 years. Some of these derivatives are suspected to be carcinogens. In this study the identity of specific phase-I enzymes involved in the metabolism of s-triazine derivatives …

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Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines.

Wolfgang A. Schmalix, Dieter H. Lang, Achim Schneider, Ronald H. Böcker et autres

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A convenient method to discriminate between cytochrome P450 enzymes and flavin-containing monooxygenases in human liver microsomes

A. Grothusen, J. Hardt, Lars Bräutigam, Dieter H. Lang et autres

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Stable Expression of Human Cytochrome P450 3A4 in Conjunction with Human NADPH-Cytochrome P450 Oxidoreductase in V79 Chinese Hamster Cells

Anneliese Schneider, Wolfgang A. Schmalix, Els M. de Groene, G. Jean Horbach et autres

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In vitro metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in rats, pigs, and humans.

Dieter H. Lang, D Criegee, A. Grothusen, R W Saalfrank et autres

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