Grisell Starita-Fajardo

Molecular Pathogenesis and Targeted Therapies in Eosinophilic Granulomatosis with Polyangiitis: An Updated Review

María López Paraja, Grisell Starita-Fajardo, Ignacio Donate Velasco, David Lucena López et autres

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis characterized by asthma, eosinophilia, and necrotizing inflammation of small- to medium-sized vessels. Accumulating evidence indicates that EGPA is a polygenic and heterogeneous disorder comprising distinct antineutrophil cytoplasmic antibody (ANCA)-defined endotypes with divergent …

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Advances in the Molecular Mechanisms of Pulmonary Fibrosis in Systemic Sclerosis: A Comprehensive Review

Maria P. Alcolea, Grisell Starita-Fajardo, Mercedes Peña Rodríguez, David Lucena López et autres

This document provides an updated overview of the molecular mechanisms underlying pulmonary fibrosis associated with Systemic Sclerosis (SSc). It summarizes current knowledge on how immune activation, vascular injury, and impaired tissue repair contribute to interstitial lung disease (ILD), which is the most …

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New Developments in the Treatment of IgG4-Related Disease: A Comprehensive Clinical Approach

Andrés González García, Grisell Starita-Fajardo, David Lucena López, Maria P. Alcolea et autres

Immunoglobulin G4-related disease (IgG4-RD) is an uncommon fibro-inflammatory process characterized by the infiltration of tissues and organs and a typically dramatic response to glucocorticoids. Its relapsing-remitting course, multisystemic involvement, and variability in epidemiological and prognostic features pose a significant diagnostic challenge for …

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Pneumococcal disease, atypical presentation in an atypical setting: a case report

David Lucena López, Grisell Starita-Fajardo, Maria Eugenia Arruza-Santos, Ana Rosa Albandea-Jiménez et autres

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Sarcoidosis

C. Arévalo-Cañas, Grisell Starita-Fajardo, L. Salmerón-Godoy, M. Andreo-Galera

Resumen La sarcoidosis es una enfermedad inflamatoria sistémica caracterizada por la formación de granulomas no caseificantes que puede afectar a cualquier órgano, siendo el pulmón el más característico. Para establecer el diagnóstico es fundamental la demostración de granulomas no necrotizantes en una …

Temporal relationship between sarcoidosis and malignancies in a nationwide cohort of 1942 patients

Pilar Brito‐Zerón, Alejandra Flores-Chávez, Luis González‐de Paz, Carlos Feijoo-Massó et autres

PURPOSE: To investigate the phenotype of sarcoidosis according to the time when a malignancy is diagnosed (preexisting to the diagnosis of sarcoidosis, concomitant, or sequential) and to identify prognostic factors associated with malignancies in a large cohort of patients with sarcoidosis. METHODS: …

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Treatment Strategies in Neutrophilic Dermatoses: A Comprehensive Review

Grisell Starita-Fajardo, David Lucena López, María Asunción Ballester‐Martínez, M. Fernández‐Guarino et autres

Neutrophilic dermatoses (NDs) are a group of noninfectious disorders characterized by the presence of a sterile neutrophilic infiltrate without vasculitis histopathology. Their physiopathology is not fully understood. The association between neutrophilic dermatoses and autoinflammatory diseases has led some authors to propose that …

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Cefalea y fiebre: no todo es lo que parece

María Pilar Iranzo-Alcolea, Carmen Ariño-Palao, Grisell Starita-Fajardo, Andrés González García et autres

La Kikuchi-Fujimoto o linfadenitis histiocítica necrotizante es una enfermedad rara, habitualmente benigna y autolimitada. Sin embargo, en ocasiones se asocia a diferentes manifestaciones sistémicas que pueden condicionar una mortalidad significativa si no se identifican y tratan. Presentamos el caso de una paciente …

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Predicting critical illness on initial diagnosis of COVID-19 based on easily obtained clinical variables: development and validation of the PRIORITY model

Miguel Martínez-Lacalzada, Adrián Viteri-Noël, Luís Manzano, M. Fabregate et autres

Objectives We aimed to develop and validate a prediction model, based on clinical history and examination findings on initial diagnosis of coronavirus disease 2019 (COVID-19), to identify patients at risk of critical outcomes. Methods We used data from the SEMI-COVID-19 Registry, a …

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Aortitis in the setting of catastrophic antiphospholipid syndrome in a patient with systemic lupus erythematosus

Andrés González García, M. López Rodríguez, Sandra Redondo López, Pilar Massó et autres

Catastrophic antiphospholipid syndrome (CAPS) is a rare condition characterized by multiple thromboses affecting mainly small vessels in a short period of time in patients with antiphospholipid antibodies. A high suspicion index is mandatory in order to initiate rapidly aggressive immunomodulatory therapy to …

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