Martha S. Field

Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans

Christopher Mellor, Brandon T James, Saeideh Azad, Emma P. Kosmeder et autres

Abstract Folate metabolites are chemically unstable: spontaneous decomposition releases formaldehyde, a genotoxin in blood stem cells and a human carcinogen. Despite this, folic acid consumption frequently exceeds the Recommended Dietary Allowance and is prescribed at high doses for patients with blood disorders. …

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B12 Supplementation Impacts Mitochondrial Biology and Skeletal Muscle Physiology in Aged Female Mice

A.C. Williamson, Shelby Rorrer, Wenxia Ma, James Mobley et autres

Objectives: Vitamin B12 (B12) deficiency is highly prevalent in the aged population due to the age-related loss of B12 absorption, independent of dietary intake. Older individuals with lower B12 have shown increased risk for sarcopenia; however, the relationship between B12 and skeletal …

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Interactions Between Mitochondrial Folate Metabolism and Alpha-Synuclein Pathology in Cultured Cells

Caitlyn M. Pelletier, Martha S. Field

Impact of Saireito intake during pregnancy and lactation on maternal and child health outcomes – a systematic review

Kuruba Yamini Priyanka, Anju Sinha, Rounik Talukdar, Amanda J. MacFarlane et autres

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Vitamin B12 improves skeletal muscle mitochondrial biology in aged mice

A.C. Williamson, Angad Yadav, Wenxia Ma, Susan Schmitt et autres

Age-related skeletal muscle deterioration is a commonly reported disability among older adults, attributed to several factors including mitochondrial dysfunction, a major hallmark of aging. Therapies to attenuate or reverse mitochondrial decline are limited. Despite identified positive relationships between vitamin B12 (B12) and …

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Abstract 935: Nutritional disruption of folate homeostasis triggers an endogenous genotoxic carcinogen.

Christopher Mellor, Saeideh Azad, Nicholas W. Cheng, B Summers James et autres

Abstract Background: Formaldehyde, a human carcinogen found in industrial chemicals, is also produced by mammalian metabolism. The toxicity of endogenous formaldehyde is most severe in children with inborn errors in formaldehyde detoxification enzymes (ALDH2/ADH5), causing early-onset bone marrow failure and leukemia through …

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Vitamin B12 Supports Skeletal Muscle Oxidative Phosphorylation Capacity in Male Mice

Luisa F. Castillo, Katarina E. Heyden, A.C. Williamson, Wenxia Ma et autres

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Vitamin B12 Improves Skeletal Muscle Mitochondrial Biology in Aged Mice

A.C. Williamson, Angad Yadav, Wenxia Ma, Susan Schmitt et autres

Age-related skeletal muscle deterioration is a commonly reported disability among older adults, attributed to several factors including mitochondrial dysfunction, a major hallmark of aging. Therapies to attenuate or reverse mitochondrial decline are limited. Despite identified positive relationships between vitamin B12 (B12) and …

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Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes

Joydeep Chakraborty, Adhideb Ghosh, Eunice B Awuah, Sally P. Stabler et autres

Folate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and peripheral neuropathy (PN). The development of peripheral neuropathy was assessed in Shmt1+/- and Shmt1-/- mice, which are models …

Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes

Joydeep Chakraborty, Adhideb Ghosh, Eunice B Awuah, Sally P. Stabler et autres

Folate-mediated one-carbon metabolism is implicated in several pathologies including neural tube defects (NTDs), cancer, and neurodegenerative disorders, whereas diabetes is associated with NTDs and peripheral neuropathy (PN). The development of peripheral neuropathy was assessed in Shmt1 +/− and Shmt1 −/− mice, which …

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Identifying the Safe and Adequate Folic Acid Intake Range Using Biomarkers in 2 Mouse Models

Esther Munezero, Kathryn E. Hopperton, Nathalie A. Behan, Fernando M. G. Matias et autres

BACKGROUND: High intakes of folic acid (FA), the synthetic form of folate added to fortified foods and supplements, have been associated with adverse effects in studies in animals and humans, albeit inconsistently. Animal models are integral to investigating these relationships; however, it …

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Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, A.C. Williamson, Wenxia Ma et autres

Abstract Objectives Vitamin B12 plays a vital role in folate-mediated one-carbon metabolism (FOCM), a series of one-carbon transfer reactions that generate nucleotides (thymidylate (dTMP) and purines) and methionine. Inadequate levels of B12 impair FOCM, depressing de novo thymidylate (dTMP) synthesis, which in …

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