Nijmeh Alsaadi

Platelet function assays fail to detect differences between transfusion of cold or room temperature platelets in traumatic brain injury patients

Jack R. Killinger, Nijmeh Alsaadi, James F. Luther, Abiha Abdullah et autres

BACKGROUND: Traumatic brain injury (TBI) patients on antiplatelet medications lack definitive treatment for reversal of platelet inhibition and restoration of injury-induced platelet dysfunction. The use of platelet transfusions in this patient population remains controversial. Cold-stored platelets (CSPs) may be hemostatically superior to …

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An Association for Women Surgeons Developed Toolkit for Cross-Mentoring in Surgery

Priyanka Chugh, Sultan Abdelhamid, Anna Kobzeva-Herzog, Gordana Rasic et autres

Summary: As our surgical workforce diversifies, mentoring relationships will need to evolve and become more inclusive for a diverse population of mentees with various backgrounds and identities. Concerted efforts to develop skills in cross-mentoring, or mentoring across differences, is essential to address …

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Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy

Nijmeh Alsaadi, Reem Younes, Jack R. Killinger, Lara Hoteit et autres

INTRODUCTION: Traumatic brain injury (TBI) patients on antiplatelet therapy face higher mortality because of impaired platelet function, which may be treated by platelet transfusion. The value of testing platelet function in this cohort remains controversial. We aimed to evaluate the relationship between …

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Long wavelength light exposure reduces systemic inflammation coagulopathy and acute organ injury following multiple injuries in mice

Mohammadreza Zarisfi, Reem Younes, Nijmeh Alsaadi, Zeyu Liu et autres

BACKGROUND: Evidence suggests that variation in light exposure strongly influences the dynamic of inflammation, coagulation, and the immune system. Multiple injuries induce systemic inflammation that can lead to end-organ injury. Here, we hypothesize that alterations in light exposure influence posttrauma inflammation, coagulopathy, …

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PB0894 Evaluating Platelet Function Post Transfusion with Cold-Stored vs Room Temperature Platelets in Patients with Traumatic Brain Injury

Lara Hoteit, Amudan J. Srinivasan, Devin M. Dishong, Emily Mihalko et autres

PB0614 Use of a Microfluidic Model to Evaluate Platelet Function in Traumatic Brain Injury Patients Pre- and Post- Platelet Transfusion

Devin M. Dishong, Emily Mihalko, Amudan J. Srinivasan, Lara Hoteit et autres

MACROPHAGE SWITCHING: POLARIZATION AND MOBILIZATION AFTER TRAUMA

Lara Hoteit, Patricia Loughran, Shannon Haldeman, Danielle Reiser et autres

ABSTRACT: Introduction: Trauma alters the immune response in numerous ways, affecting both the innate and adaptive responses. Macrophages play an important role in inflammation and wound healing following injury. We hypothesize that macrophages mobilize from the circulation to the site of injury …

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EFFECT OF IRRIGATION FLUID COMPOSITION ON HEMOSTASIS IN MOUSE BLEEDING MODELS

Nijmeh Alsaadi, Adnan Hassoune, Shannon Haldeman, Kelly Williamson et autres

ABSTRACT: Introduction: Intraoperative irrigation, usually with normal saline (NS), aids in bleeding identification and management. We investigated the effect of different irrigation fluids, with additives, on hemostasis using two bleeding models. Methods: C57BL/6 J mice were subjected to a tail bleed model …

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Irrigation Fluid Composition Affects Hemostasis in Murine Bleeding Models

Nijmeh Alsaadi, Adnan Hassoune, Shannon Haldeman, Kelly Williamson et autres

Introduction: Intraoperative irrigation, usually with normal saline (NS), aids in bleeding identification and management. We investigated the effect of different irrigation fluids, with additives, on hemostasis using two bleeding models. Methods: C57BL/6J mice were subjected to a tail bleed model or uncontrolled …

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Caspase-11 Contributes to Trauma-Induced Coagulopathy in a Murine Polytrauma Model

Nijmeh Alsaadi, Joud Mulla, Zachary Secunda, Bashar Al Matour et autres

Introduction: Trauma-induced coagulopathy (TIC) results in significant morbidity and mortality. Caspase-4/11 is associated with disseminated intravascular coagulation in sepsis, but its role in polytrauma is unknown. We sought to investigate the effects of caspase-11 in a murine polytrauma model. Methods: C57BL/6 (WT) …

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Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies

Aditya Girish, Ketan Jolly, Nijmeh Alsaadi, María de la Fuente et autres

Severe hemorrhage associated with trauma, surgery, and congenital or drug-induced coagulopathies can be life-threatening and requires rapid hemostatic management via topical, intracavitary, or intravenous routes. For injuries that are not easily accessible externally, intravenous hemostatic approaches are needed. The clinical gold standard …

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Chemotherapy extravasation injuries beyond the immediate stage: A series of 15 cases treated according to a preset surgical algorithm based on time of presentation

Samer Abdel Al, Wafa Asha, A. Asha, Mohamad K. Abou Chaar et autres

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