Thibault Renoir

Psilocybin restores social novelty investigation in male SAPAP3 knockout mice and engages prefrontal–hippocampal circuitry

James J Gattuso, Bilgenur Bezcioglu, Jenna Hendey, Jennyfer M. Payet et autres

Obsessive-compulsive disorder (OCD) remains difficult to treat, and evidence indicates that social dysfunction, common across obsessive-compulsive and related disorders, is an under-recognized clinical burden. SAPAP3 knockout (KO) mice, a well-established model of compulsive behavior, exhibit social abnormalities, suggesting broader disruptions in circuits …

au (code pays fourni par la source)

Effects of microplastics and nanoplastics on the brain and behavior: Evidence from rodent and human studies

Liana Fattore, Thibault Renoir, Anthony J. Hannan, Ankit Siwach et autres

Microplastics (MPs) and nanoplastics (NPs) pose serious environmental and health risks and have made plastic pollution a major concern worldwide. They have been detected in terrestrial and aquatic species, including humans, and have been linked to increased risks of cardiovascular, respiratory and …

it, au, Égypte, fr (code pays fourni par la source)

Psilocybin produces amplified acute responses and sex-specific long-term increases in sensorimotor gating in the mGlu5 knockout mouse model of schizophrenia

James J Gattuso, Ähmed Kamal, Jennyfer M. Payet, Kato Havaux et autres

Abstract Psilocybin is a serotonergic psychedelic drug with emerging therapeutic applications, yet its actions under glutamatergic dysfunction, and relevance to schizophrenia and associated psychiatric disorders, remain unclear. We examined the acute and long-lasting effects of psilocybin (1 mg/kg, intraperitoneal) on behavioral and …

au (code pays fourni par la source)

Targeting miR‐124‐3p to Induce Antidepressant‐Like Effects in Female Mice: MicroRNA Modulation of Stress Resilience

Kuznetsova Ma, Alexandra Fraser, Ching‐Seng Ang, Nicholas A. Williamson et autres

MicroRNAs (miRNAs) play crucial roles in regulating gene expression and have been implicated in the pathophysiology of depression. Among them, miR-124-3p is one of the most abundant brain-enriched miRNAs and has emerged as a potential therapeutic target for mood disorders. This study …

au (code pays fourni par la source)

Author response for "Targeting miR-124-3p to induce antidepressant-like effects in female mice: microRNA modulation of stress resilience"

Maria A. Kuznetsova, Alexandra Fraser, Ching‐Seng Ang, Nicholas A. Williamson et autres

Author response for "Targeting miR-124-3p to induce antidepressant-like effects in female mice: microRNA modulation of stress resilience"

Maria A. Kuznetsova, Alexandra Fraser, Ching‐Seng Ang, Nicholas A. Williamson et autres

Inhibition of the NLRP3 Inflammasome With MCC950 Improves Gut Health in Huntington's Disease Mice

Sujan Kumar Sarkar, Millicent N. Ekwudo, Da-Yong Lu, Bethany A. Masson et autres

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder featuring abnormal cognition, psychiatric symptoms, movement, and gastrointestinal function. It is caused by a tandem-repeat gene mutation encoding an expanded polyglutamine tract in the huntingtin protein. Our group was the first to demonstrate …

au, bd (code pays fourni par la source)

Author response for "Inhibition of the NLRP3 inflammasome with MCC950 improves gut health in Huntington’s disease mice"

Sujan Kumar Sarkar, Millicent N. Ekwudo, Da Lu, Bethany A. Masson et autres

Acute Blockade of the Serotonin Transporter With Low Doses of Escitalopram Does Not Alter the Behavioural Responses to Acute Psilocybin

Nina Kleditzsch, James J Gattuso, Anthony J. Hannan, Thibault Renoir

The psychedelic psilocybin has gained popularity in recent years as a therapy for treatment-resistant depression and has been reported to reduce symptoms of depression and anxiety. Psilocybin's active metabolite, psilocin, possesses a binding affinity for serotonin receptors as well as for the …

dk, au (code pays fourni par la source)

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

Rachel Hill, Eslam M. Bastawy, Michael Berk, Robyn M. Brown et autres

au, us (code pays fourni par la source)

Author response for "Acute blockade of the serotonin transporter with low doses of escitalopram does not alter the behavioural responses to acute psilocybin"

Nina Kleditzsch, James J Gattuso, Anthony J. Hannan, Thibault Renoir

Psilocybin's effects on obsessive-compulsive behaviors: A systematic review of preclinical and clinical evidence

James J Gattuso, Bilgenur Bezcioglu, Carey Wilson, Kato Havaux et autres

Psilocybin is a serotonergic psychedelic with growing evidence for efficacy in mood disorders, and its therapeutic potential in obsessive—compulsive disorder (OCD) and related conditions is increasingly recognised but remains understudied. We systematically evaluated clinical and preclinical evidence on psilocybin's effects on obsessive …

au (code pays fourni par la source)