Raúl G. Saraiva

Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden

Emma Camacho, Yuemei Dong, Christine Chrissian, Radamés J. B. Cordero et autres

L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigate the effect of dietary L-DOPA on mosquito physiology and …

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Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden

Emma Camacho, Yuemei Dong, Christine Chrissian, Radamés J. B. Cordero et autres

us (code pays fourni par la source)

Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos while reducing their lifespan and malaria parasite burden

Emma Camacho, Yuemei Dong, Christine Chrissian, Radamés J. B. Cordero et autres

ABSTRACT L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigate the effect of dietary L-DOPA on mosquito physiology …

us (code pays fourni par la source)

The roles, challenges, and merits of the p value

Oliver Y. Chén, Julien Bodelet, Raúl G. Saraiva, Huy P. Phan et autres

Since the 18th century, the p value has been an important part of hypothesis-based scientific investigation. As statistical and data science engines accelerate, questions emerge: to what extent are scientific discoveries based on p values reliable and reproducible? Should one adjust the …

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Thou Shalt Not Reject the P-value

Oliver Y. Chén, Raúl G. Saraiva, Guy Nagels, Huy P. Phan et autres

Since its debut in the 18th century, the P-value has been an important part of hypothesis testing-based scientific discoveries. As the statistical engine accelerates, questions are beginning to be raised, asking to what extent scientific discoveries based on a P-value are reliable …

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Thou Shalt Not Reject the $\textit{P}$-value

Oliver Y. Chén, Raúl G. Saraiva, Guy Nagels, Huy Phan et autres

Thou Shalt Not Reject the P-value

Oliver Y. Chén, Raúl G. Saraiva, Guy Nagels, Huy P. Phan et autres

Since its debut in the 18th century, the P-value has been an important part of hypothesis testing-based scientific discoveries. As the statistical engine accelerates, questions are beginning to be raised, asking to what extent scientific discoveries based on P-values are reliable and …

Bacterial natural products in the fight against mosquito-transmitted tropical diseases

Raúl G. Saraiva, George Dimopoulos

Covering: up to 2019 Secondary metabolites of microbial origin have long been acknowledged as medically relevant, but their full potential remains largely unexploited. Of the countless natural compounds discovered thus far, only 5-10% have been isolated from microorganisms. At the same time, …

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The role of OmpF and OmpC porins on the translocation of fluoroquinolones and their metallocomplexes across the outer membrane of E. coli

Raúl G. Saraiva, Matthew P. McCusker, Séamus Fanning, Paula Gameiro et autres

Background: OmpF and OmpC, the major outer membrane porins in E. coli , are believed to play a major role in the internalization of fluoroquinolones. Moreover, the quick development of bacterial resistance to these drugs has led to the need for their …

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Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein

Raúl G. Saraiva, Jingru Fang, Seokyoung Kang, Yesseinia Angleró-Rodríguez et autres

Dengue virus (DENV) is the most prevalent and burdensome arbovirus transmitted by Aedes mosquitoes, against which there is only a limited licensed vaccine and no approved drug treatment. A Chromobacterium species, C. sp. Panama, isolated from the midgut of A. aegypti is …

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Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin

Raúl G. Saraiva, Callie R. Huitt-Roehl, Abhai K. Tripathi, Yi‐Qiang Cheng et autres

The Chromobacterium sp. Panama bacterium has in vivo and in vitro anti-Plasmodium properties. To assess the nature of the Chromobacterium-produced anti-Plasmodium factors, chemical partition was conducted by bioassay-guided fractionation where different fractions were assayed for activity against asexual stages of P. falciparum. …

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Functional genomic analyses of Enterobacter, Anopheles and Plasmodium reciprocal interactions that impact vector competence

Nathan Dennison, Raúl G. Saraiva, Chris M. Cirimotich, Godfree Mlambo et autres

BACKGROUND: Malaria exerts a tremendous socioeconomic impact worldwide despite current control efforts, and novel disease transmission-blocking strategies are urgently needed. The Enterobacter bacterium Esp_Z, which is naturally harboured in the mosquito midgut, can inhibit the development of Plasmodium parasites prior to their …

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