Jeremy M. Nell

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Maria Carrabba, Fabiana Mascarenhas Souza Lima, Giuliana Giardino, Giulia M. Martone et autres

us (code pays fourni par la source)

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

John C. McDonnell, Kimberley L. Cousins, M. Elizabeth M. Younger, Adam Lane et autres

BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect …

us, se, ir, om, pe, sa, ar, tr, it, es, au, ca, co, Égypte, ae, br, mx, bg, nz, cr, sg (code pays fourni par la source)

Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19

Neil R. Aggarwal, Jacquie Nordwall, Dominique L. Braun, Lucy K. Chung et autres

BACKGROUND: Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 …

us, ch, Nigéria, es, dk, gb, gr (code pays fourni par la source)

Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19

Tomas Østergaard Jensen, Greg Grandits, Mamta K. Jain, Thomas A. Murray et autres

BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood. METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb …

dk, us, gb, gr, Ouganda, au (code pays fourni par la source)

Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history

Hailey R. Hornsby, Alexander R. Nicols, Stéphanie Longet, Chang Liu et autres

Abstract Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in many individuals possessing hybrid immunity, generated through a combination of vaccination and infection. Concerns have been raised that omicron breakthrough infections in triple-vaccinated individuals result in poor induction of omicron-specific …

gb, us, th, Gambie (code pays fourni par la source)

Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens

Shona C. Moore, Barbara Kronsteiner, Stephanie Longet, Sandra Adele et autres

BACKGROUND: Both infection and vaccination, alone or in combination, generate antibody and T cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the maintenance of such responses-and hence protection from disease-requires careful characterization. In a large prospective study of UK …

gb, kh, th (code pays fourni par la source)

Omicron BA.1/BA.2 infections in triple-vaccinated individuals enhance a diverse repertoire of mucosal and blood immune responses

Hailey R. Hornsby, Alexander R. Nicols, Stéphanie Longet, Chang Liu et autres

Abstract Pronounced immune escape by the SARS-CoV-2 Omicron variant has resulted in large numbers of individuals with hybrid immunity, generated through a combination of vaccination and infection. Based primarily on circulating neutralizing antibody (NAb) data, concerns have been raised that omicron breakthrough …

gb, us, th, Gambie (code pays fourni par la source)

Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience

Adrian Matthew Shields, Susan Tadros, Adam Al‐Hakim, Jeremy M. Nell et autres

Background: Individuals with primary and secondary immunodeficiency (PID/SID) were shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic. SARS-CoV-2 vaccines demonstrate reduced immunogenicity in these patients. Objectives: To understand whether the risk of severe COVID-19 …

gb (code pays fourni par la source)

Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Karin Hardt, An Vandebosch, JERALD C. SADOFF, Mathieu Le Gars et autres

be, nl, gb, de (code pays fourni par la source)

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19

Eleftherios E Mylonakis, Barnaby Edward Young, David M. Vock, Lianne K. Siegel et autres

BACKGROUND: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. OBJECTIVE: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized …

us, gr, sg, Ouganda, gb, Nigéria, ch, dk, au, es, pl (code pays fourni par la source)

Evolution of long-term vaccine induced and hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study

Shona C. Moore, Barbara Kronsteiner, Stephanie Longet, Sandra Adele et autres

Abstract Both infection and vaccination, alone or in combination, generate antibody and T cell responses against SARS-CoV-2. However, the maintenance of such responses – and hence protection from disease – requires careful characterisation. In a large prospective study of UK healthcare workers …

gb, th (code pays fourni par la source)

Evolution of Long-Term Hybrid Immunity in Healthcare Workers after Different Covid-19 Vaccination Regimens: A Longitudinal Observational Cohort Study

Shona C. Moore, Barbara Kronsteiner, Stéphanie Longet, Sandra Adele et autres

gb, us, au, kh, ca, fr (code pays fourni par la source)