Accès ouvert
2026
article
OpenAlex
Mohamed E. Abdelsalam, Milan Patel, Ryan Murray, Shahroz Khalid Aziz et autres
Objective: To assess the safety and diagnostic outcomes of image-guided, non-target renal biopsies performed in cancer patients. Materials and Methods: We retrospectively identified patients who underwent percutaneous, image-guided, non-target renal biopsy between January 2017 and December 2020 in our institution. We recorded …
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Accès ouvert
2026
article
OpenAlex
Hariharan Seshadri, Evelyn Acosta, Amanda Tchakarov, Larissa A. Meyer et autres
Immune checkpoint inhibitors (ICI) are a broad class of immunotherapy drugs used across a wide range of malignancies, but these treatments can also cause autoimmune complications. Minimal change disease (MCD) is rare side effect of ICI therapy and re-challenge of ICI therapy …
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2025
article
OpenAlex
Callie J Meath, Rohtesh S. Mehta, Partow Kebriaei, Jamie S. Lin
Introduction: Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT), occurring in 5-15% of cases with mortality rates >80% once multiorgan failure develops. SOS begins with endothelial injury to hepatic sinusoids, leading to portal hypertension and subsequent …
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2025
article
OpenAlex
Jamie S. Lin, Jun Huang
In recent years, interventional pulmonology has advanced rapidly, with bronchoscopy becoming a cornerstone in the diagnosis and treatment of respiratory diseases. The integration of artificial intelligence (AI) technology has established an intelligent framework for the entire bronchoscopic diagnostic process. Image recognition enables …
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Accès ouvert
2025
article
OpenAlex
Callie J Meath, Rohtesh S. Mehta, Partow Kebriaei, Jamie S. Lin
Sinusoidal obstruction syndrome (SOS) is a life-threatening complication of hematopoietic cell transplantation that can lead to multiorgan failure, including acute kidney injury (AKI) due to hepatorenal syndrome (HRS)-like physiology. Current supportive measures often fail in preserving renal function, and dialysis is associated …
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Accès ouvert
2025
article
OpenAlex
James P. Long, Shailbala Singh, Yanlan Dong, Cassian Yee et autres
Immune checkpoint inhibitor (ICI) therapy is a cornerstone treatment for many cancers, but it can induce severe immunotoxicity, including acute interstitial nephritis (AIN). Currently, kidney biopsy is required to differentiate ICI-AIN from other causes of acute kidney injury (AKI). However, this invasive …
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2024
article
OpenAlex
Jamie S. Lin, James P. Long, Shailbala Singh, Yanlan Dong et autres
Background: Immune checkpoint inhibitor (ICI)-based cancer therapy saves lives, but ~20% of patients undergoing therapy develop acute kidney injury (AKI), and 2-5% face acute interstitial nephritis (AIN) with actionable consequences. Urine protein markers can correlate with specific kidney pathologies, yet exploring the …
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Accès ouvert
2024
article
OpenAlex
Kiran Shivaraj, Amanda Tchakarov, Yanlan Dong, Jamie S. Lin
Immune checkpoint inhibitor (ICI)-associated immune nephritis or acute interstitial nephritis (AIN) is one of the rare but known complication of ICI therapy. Guidelines recommend treatment of ICI-associated AIN with steroids, then TNF-alpha inhibitor infliximab. However, some cases are refractory to these therapies, …
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Accès ouvert
2024
article
OpenAlex
Kavya L. Singampalli, Camille Neal – Harris, Cassian Yee, Jamie S. Lin et autres
The detection and quantification of protein biomarkers in bodily fluids is important for many clinical applications, including disease diagnosis and health monitoring. Current techniques for ultrasensitive protein detection, such as enzyme-linked immunosorbent assay (ELISA) and electrochemical sensing, involve long incubation times (1.5-3 …
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2024
article
OpenAlex
Sarah Fayle, Nicolas L. Palaskas, Bilal A. Siddiqui, Jennifer L. McQuade et autres
Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for many cancer types. The clinical use of ICIs is increasing rapidly, including in combinations associated with increased risk of toxicities, termed "immune-related adverse events" (irAEs). Therefore, MD Anderson Cancer Center (MDACC) in …
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Accès ouvert
2023
article
OpenAlex
Ritu Bohat, Xiaofang Liang, Yanping Chen, C Xu et autres
Sle1 and Faslpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Faslpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6.Sle1/Sle1.Faslpr/+ …
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Accès ouvert
2023
article
OpenAlex
Anna-Ève Turcotte, William F. Glass, Jamie S. Lin, Jan A. Burger
Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment …
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