Accès ouvert
2026
article
OpenAlex
Antonella Nostroso, Roberta Marra, Barbara Eleni Rosato, Anthony Iscaro et autres
Abstract Hereditary anemias encompass a genetically heterogeneous spectrum of disorders, often involving multi‐locus inheritance, which can complicate clinical management and worsen disease severity. This study investigates the impact of the co‐inheritance of SEC23B loss‐of‐function pathogenic variants, which lead to congenital dyserythropoietic anemia …
it
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2025
article
OpenAlex
Martina Di Noto, Anastasia Xourafa, Rosamaria Rosso, Anna Bulla et autres
Introduction: Thalassemia major (TM) has a significant impact on patients' quality of life. Osteoporosis and osteopenia are common and important complications, yet they are often underestimated. Their etiology is multifactorial, culminating in reduced bone mass, impaired remodeling, and increased fracture risk. The …
it
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2025
article
OpenAlex
Maddalena Casale, Giuseppe Toro, Federica Porcelli, Vincenzo Spadola et autres
Objectives: Sickle Cell Disease (SCD) has a significant impact on the musculoskeletal system. The use of the Oxford Hip (OHS) and Shoulder score (OSS) as patient-reported outcome measures (PROMs) revealed a high rate of long-term impairment in joints with a pre-existing diagnosis …
it
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Accès ouvert
2025
article
OpenAlex
Raffaella Origa, Barbara Gianesin, Antonietta Zappu, Anna Rita Denotti et autres
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it
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Accès ouvert
2025
article
OpenAlex
Andrea Duminuco, Anna Bulla, Rosamaria Rosso, Maria Anna Romeo et autres
Background: Immune system impairment is frequently reported in patients affected by hemoglobinopathies due to various mechanisms, including iron accumulation, antigenic stimulation due to numerous transfusions, chronic hemolysis, and a general hyperinflammatory state. For these reasons, the antigenic immune response after a vaccine …
it
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2024
article
OpenAlex
Vittorio Del Fabro, Uroš Markovic, Sara Frazzetto, Roberta Sciortino et autres
Background Waldenström macroglobulinemia (WM) is a rare and indolent B-cell lymphoproliferative disorder with greater incidence in elderly patients where a precise algorithm of initial therapy is still not clear. Immunochemotherapy regimen consisting of dexamethasone, rituximab, and oral cyclophosphamide (DRC) is considered a …
it
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Accès ouvert
2023
conference-abstract
OpenAlex
Barbara Gianesin, Rosamaria Rosso, Roberto Lisi, Antonietta Zappu et autres
Luspatercept has been demonstrated to reduce the need for blood transfusion with manageable side effects in clinical trials, thus receiving the approval for the treatment of anemia associated with transfusion dependent beta thalassemia in adults. However, very little data on its safety …
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Accès ouvert
2023
preprint
OpenAlex
Andrea Duminuco, Anna Bulla, Rosamaria Rosso, Marina Romeo et autres
Abstract Purpose Immune system impairment is frequently reported in patients affected by hemoglobinopathies due to various mechanisms, including iron accumulation, antigenic stimulation due to numerous transfusions, chronic hemolysis, and a hyperinflammatory state. The antigenic immune response after a vaccine could be ineffective. …
it
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Accès ouvert
2023
article
OpenAlex
Vittorio Del Fabro, Mary Ann Di Giorgio, Valerio Leotta, Andrea Duminuco et autres
Based on the results obtained in clinical trials, the use of the combination of lenalidomide and dexamethasone (Len/Dex) has become a potential therapeutic choice for newly diagnosed multiple myeloma (NDMM) ineligible for autologous stem cell transplantation. This study evaluated 89 frail NDMM …
it
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Accès ouvert
2023
article
OpenAlex
Andrea Duminuco, Anna Bulla, Rosamaria Rosso, Marina Romeo et autres
Topic: 27. Thalassemias Background: Hemoglobinopathies are a heterogeneous group of inherited disorders characterized by alterations in hemoglobin synthesis. Immune system status of these patients is known to be altered due to underlying pathophysiological mechanisms of the disease, such as ineffective erythropoiesis (IE), …
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Accès ouvert
2023
article
OpenAlex
Andrea Duminuco, Alessandra Romano, Daniela Leotta, Enrico La Spina et autres
Introduction: Patients with multiple myeloma (MM) frequently present with substantial immune impairment and an increased risk for infection-related mortality. From the end of January 2020, infection by SARS-CoV-2 has radically changed our lives. Since the COVID-19 (COronaVIrus Disease-2019) pandemic is still ongoing, …
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Accès ouvert
2023
article
OpenAlex
Andrea Duminuco, Alessandra Romano, Dario Leotta, Enrico La Spina et autres
Introduction: Patients with multiple myeloma (MM) frequently reported immune impairment with an increased risk for infection-related mortality. We aimed to evaluate the immune response in MM patients vaccinated for SARS-CoV-2 during active treatment. Methods: We enrolled 158 patients affected by active MM …
it
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