Timothy B. Durham

LY3522348, A New Ketohexokinase Inhibitor: A First-in-Human Study in Healthy Adults

Tsuyoshi Fukuda, Brian R. Thompson, Bram Brouwers, Hui-Rong Qian et autres

us (code pays fourni par la source)

Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor

Timothy B. Durham, Junliang Hao, Patrick Spinazze, Douglas R. Stack et autres

us, es (code pays fourni par la source)

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors

Rongjun He, Jifeng Wang, Zhihong Yu, Julie S. Moyers et autres

us, fr (code pays fourni par la source)

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models

Harold B. Brooks, Timothy I. Meier, Sandaruwan Geeganage, Kevin R. Fales et autres

us (code pays fourni par la source)

CCDC 1820730: Experimental Crystal Structure Determination

Ana B. Bueno, Javier Agejas, Howard B. Broughton, Robert Dally et autres

CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis

Kacey J. Prentice, Stacy G. Wendell, Ying Liu, Judith A. Eversley et autres

ca, us (code pays fourni par la source)

Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences

Ana B. Bueno, Javier Agejas, Howard B. Broughton, Robert Dally et autres

es, us (code pays fourni par la source)

Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model

Kevin R. Fales, F. George Njoroge, Harold B. Brooks, Stefan Jon Thibodeaux et autres

us, es (code pays fourni par la source)

A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose

Timothy B. Durham, Jothirajah Marimuthu, James L. Toth, Chin Liu et autres

us (code pays fourni par la source)

Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion

E Nagy, Ying Liu, Kacey J. Prentice, Kyle W. Sloop et autres

us, ca (code pays fourni par la source)

Target Engagement Measures in Preclinical Drug Discovery: Theory, Methods, and Case Studies

Timothy B. Durham, Michael R. Wiley

us (code pays fourni par la source)

Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors

Michael R. Wiley, Timothy B. Durham, Lisa A. Adams, M.G. Chambers et autres

us (code pays fourni par la source)