Elena Fernández‐Durán

Influence of state-of-the-art laboratory techniques on the phenotyping of women with polycystic ovary syndrome in the clinical setting

Manuel Luque‐Ramírez, M. Ángeles Martínez‐García, María Insenser, Elena Fernández‐Durán et autres

PURPOSE: Evidence-based guidelines for the management of polycystic ovary syndrome (PCOS) recommend clinical laboratories use liquid chromatography-tandem mass spectrometry (LC-MS/MS) for diagnosing biochemical hyperandrogenism. However, automated immunoassays are still mostly used in routine laboratories worldwide. Another hurdle for PCOS phenotyping in the …

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Obesity and polycystic ovary syndrome influence on intestinal permeability at fasting, and modify the effect of diverse macronutrients on the gut barrier

M. Ángeles Martínez‐García, Alejandra Quintero-Tobar, Sara de Lope Quiñones, María Insenser et autres

Women with the extremely prevalent polycystic ovary syndromegather multiple cardiovascular risk factors and chronic subclinical inflammation. Interactions between diet, adiposity, and gut microbiota modulate intestinal permeabilityand bacterial product translocation, and may contribute to the chronic inflammation process associated with the polycystic ovary …

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“Arterial stiffness is not associated with changes in the circadian pattern of blood pressure in patients with type 1 diabetes mellitus and cardiovascular autonomic dysfunction”

Lía Nattero‐Chávez, A. Bayona Cebada, Elena Fernández‐Durán, Alejandra Quintero Tobar et autres

Introduction Cardiovascular autonomic neuropathy (CAN) associates an abnormal circadian pattern in blood pressure (BP) regulation that might be aggravated by the coexistence of arterial stiffness. We aimed to evaluate the effect of arterial stiffness in the circadian rhythm of BP in patients …

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Sex differences and sex steroids influence on the presentation and severity of cardiovascular autonomic neuropathy of patients with type 1 diabetes

Lía Nattero‐Chávez, María Insenser, Alejandra Quintero Tobar, Elena Fernández‐Durán et autres

Abstract Background Sex differences characterize cardiovascular outcomes in patients with type 1 diabetes. Cardioautonomic neuropathy is a common complication of type 1 diabetes that associates increased morbi-mortality. Data regarding the interplay between sex and cardiovascular autonomic neuropathy are scarce and controversial in …

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Effect of Iron Depletion by Bloodletting vs. Observation on Oxidative Stress Biomarkers of Women with Functional Hyperandrogenism Taking a Combined Oral Contraceptive: A Randomized Clinical Trial

Manuel Luque‐Ramírez, A.E. Ortiz-Flores, M. Ángeles Martínez‐García, María Insenser et autres

Women with functional hyperandrogenism show both increased markers of oxidative stress and a mild iron overload. Combined oral contraceptives (COC) may worsen redox status in the general population. Since iron depletion ameliorates oxidative stress in other iron overload states, we aimed to …

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Point‐of‐care sural nerve conduction could predict the presence of cardiovascular autonomic neuropathy in type 1 diabetes mellitus

Lía Nattero‐Chávez, Manuel Luque‐Ramírez, Jhonatan Quiñones‐Silva, Laura Montánez et autres

ABSTRACT Aims Assessment for cardiovascular autonomic neuropathy (CAN) in patients with type 1 diabetes mellitus remains time‐consuming in the clinical setting. We aimed to examine the diagnostic performance of a portable point‐of‐care diagnostic tool (POCD) for assessing sural nerve conduction during the …

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Impact of excluding hyperglycemia from international diabetes federation metabolic syndrome diagnostic criteria on prevalence of the syndrome and its association with microvascular complications, in adult patients with type 1 diabetes

Edurne Lecumberri, Lía Nattero‐Chávez, Jhonatan Quiñones Silva, Sara Alonso Díaz et autres

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High serum copeptin may be a marker of an increased carotid intima-media thickness in asymptomatic patients with type 1 diabetes

Lía Nattero‐Chávez, M. Ángeles Martínez‐García, Sandra Redondo López, Elena Fernández‐Durán et autres

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Bloodletting has no effect on the blood pressure abnormalities of hyperandrogenic women taking oral contraceptives in a randomized clinical trial

Manuel Luque‐Ramírez, A.E. Ortiz-Flores, Lía Nattero‐Chávez, M. Ángeles Martínez‐García et autres

Normoferritinemic women with functional hyperandrogenism show a mild iron overload. Iron excess, hyperandrogenism, and cardioautonomic dysfunction contribute to blood pressure (BP) abnormalities in these patients. Furthermore, combined oral contraceptives (COC) prescribed for hyperandrogenic symptoms may worse BP recordings. Iron depletion by phlebotomy …

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High serum copeptin may be a marker of an increased carotid intima-media thickness in asymptomatic patients with type 1 diabetes.

Lía Nattero‐Chávez, M. Ángeles Martínez‐García, Elena Fernández‐Durán, Sandra Redondo López et autres

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Iron Overload in Functional Hyperandrogenism: In a Randomized Trial, Bloodletting Does Not Improve Metabolic Outcomes

A.E. Ortiz-Flores, M. Ángeles Martínez‐García, Lía Nattero‐Chávez, Francisco Álvarez‐Blasco et autres

CONTEXT: Functional hyperandrogenism may be associated with a mild increase in body iron stores. Iron depletion exerts a beneficial effect on metabolic endpoints in other iron overload states. OBJECTIVES: (i) To determine the effect of iron depletion on the insulin sensitivity and …

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Fasting serum copeptin and asymptomatic peripheral artery disease: No association in patients with type 1 diabetes mellitus

Lía Nattero‐Chávez, M. Ángeles Martínez‐García, Elena Fernández‐Durán, Sandra Redondo López et autres

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