Akihisa Matsuda

Laparoscopic Surgery Is Associated With Reduced Small Bowel Obstruction Risk After Colorectal Cancer Surgery: A Nationwide Cohort Study of 5458 Patients

Takeshi Yamada, Fumihiko Fujita, Ken Eto, Kozo Kataoka et autres

ABSTRACT Introduction Postoperative small bowel obstruction (SBO) is a major complication following colorectal cancer surgery, yet evidence‐based prevention strategies remain unclear. We aimed to clarify site‐specific risk factors for SBO and evaluate the effectiveness of laparoscopic surgery and adhesion prevention materials (APMs) …

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Chemotherapy After Colonic Stent in Patients With Unresectable Obstructive Colorectal Cancer: A Retrospective Multicenter Observational Study

Akihisa Matsuda, Norihiro Hanabata, Yorinobu Sumida, Naohiko Harada et autres

Abstract Backgrounds and study aim Placement of a self-expandable metallic stent (SEMS) has become a common practice for obstructive colorectal cancer. However, the safety and efficacy of systemic chemotherapy after SEMS placement remain unclear. Patients and methods This multicenter retrospective cohort study …

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Morphological and functional responses of three-dimensional-cultured colorectal cancer spheres to anticancer drugs

Yusuke Yoshimura, Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada et autres

BACKGROUND Three-dimensional (3D) culture systems closely recapitulate the tumor microenvironment, allowing the assessment of drug effects on cell-cell interactions and metabolic heterogeneity. Colorectal adenocarcinoma (CRAC) cells exhibit epithelial and mesenchymal features, reflecting tumor heterogeneity, which may influence drug sensitivity. However, the morphological …

Utility of Urinary Extracellular Vesicles for Colorectal Cancer: Comparison of DNA Quality and MRD Detection

Shintaro Kanaka, Takeshi Yamada, Fumi Asai, Yuta Shimizu et autres

This study evaluated the feasibility of urinary extracellular vesicles (EVs) as a liquid biopsy source for colorectal cancer (CRC) using two predefined cohorts: 97 patients for analytical validation and 63 patients for postoperative survival analysis. We compared urinary EVs, urinary cell-free tumor …

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Prolonged surgical time and hypoalbuminemia as risk factors for adverse outcomes after esophagectomy: a multicenter study with age-stratified and spline-based analysis

Satoshi Nomura, Takeshi Yamada, Takuya Nishino, Takeshi Matsutani et autres

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Lecithinized superoxide dismutase prevents oxaliplatin-induced peripheral neuropathy: a double-blind, placebo-controlled, randomized phase II study

Takeshi Yamada, Taishi Hata, Atsushi Ishiguro, Yoshinori Munemoto et autres

Background Oxaliplatin-based adjuvant chemotherapy improves recurrence-free survival in stage II/III colorectal cancer (CRC) patients. However, oxaliplatin treatment is frequently limited by chemotherapy-induced peripheral neuropathy (CIPN). Oxidative stress is implicated in CIPN pathogenesis. Lecithinized superoxide dismutase (PC-SOD) is a long-circulating antioxidant enzyme that …

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Clinical utility of a novel concentrated enteral formula in patients undergoing colorectal cancer surgery: A randomized controlled trial

Seiichi Shinji, Takeshi Yamada, Akihisa Matsuda, Yasuyuki Yokoyama et autres

BACKGROUND: Compared to standard hospital meals, nutritional intervention using recovery K5 (RK5), a concentrated liquid diet, offers a comprehensive immunonutritional profile, suggesting its potential effectiveness in preventing surgical site infections (SSIs) after gastrointestinal surgery. AIM: To investigate the usefulness of RK5 in …

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Total Neoadjuvant Therapy for Rectal Cancer: Why Japan Says “Not Yet”

Akihisa Matsuda, Takeshi Yamada, Aitsariya Monkhonsupphawan, Hiroshi Yoshida

Total neoadjuvant therapy (TNT) has rapidly gained global acceptance as a standard treatment for locally advanced rectal cancer (LARC). Supported by multiple phase III trials, TNT improves pathological complete response (pCR) rates, enhances systemic control, and expands opportunities for non-operative management (NOM). …

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Operative Time as a Universal Risk Factor for Infectious Complications after Colorectal Cancer Surgery: A Multicenter Stratified Analysis by Surgical Site

Takao Shimizu, Takeshi Yamada, Takuya Nishino, Akihisa Matsuda et autres

Objectives: Postoperative infectious complications in colorectal cancer prolong hospital stays and increase the risk of recurrence. Given that risk factors may vary depending on the surgical procedure-namely, right-sided colon, left-sided colon, and rectal cancer-we aimed to identify both common and procedure-specific risk …

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Analysis of diverting ileostomy for colorectal cancer surgery: Stenosis and T4 invasion are risk factors of reoperation due to anastomotic leakage, even when ileostomy is performed

Kohki Takeda, Yamada Takeshi, Ryo Ohta, Akihisa Matsuda et autres

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The Influence of Surgeons' Gender on Surgical Outcomes in Laparoscopic Right Hemicolectomy: A Japanese Nationwide Retrospective Cohort Study

Akihisa Matsuda, Hideki Endo, Aya Yamagishi, Hiroyuki Yamamoto et autres

Background: In Japan, the rapid reduction and aging of surgeons have become a serious problem in gastroenterological surgery field, therefore, an increase in the number and the activity of female surgeons is essential. Previous most studies comparing surgical outcomes between male and …

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Effect of preserving the bronchial artery and the azygos arch in McKeown esophagectomy: a systematic review and meta‑analysis

Tomohiko Yasuda, Akihisa Matsuda, Nobutoshi Hagiwara, Masanori Watanabe et autres

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