Accès ouvert
2026
article
OpenAlex
David Beniaguev, Sapir Shapira, Idan Segev, M London
A cortical neuron typically makes multiple synaptic contacts on the dendrites of its postsynaptic target neuron. The functional implications of this apparent redundancy are unclear. Due to dendritic cable filtering, proximal dendritic synapses generate brief somatic postsynaptic potentials (PSPs) whereas distal synapses …
il
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Netanel Ofer, Sapir Shapira, Idan Segev
Dendritic spines are nano-scale compartments that host the majority of excitatory synapses on cortical pyramidal neurons (PNs); hundreds of spines/PN also receive an inhibitory synapse (dually-innervated spines, DiSs). Using analytic theory and detailed biophysical models of ~2,000 densely reconstructed spines, we show …
il
(code pays fourni par la source)
2025
preprint
OpenAlex
Vittoria Avaro, Elham Anwer Taha, Sapir Shapira, Thomas Hummel et autres
SUMMARY Olfaction enables us to detect chemicals in the environment, and its impairment affects one in four people worldwide. As the most common therapy, olfactory training involves repeated exposure to odorants restoring function in 30-50% of patients. However, the mechanisms underlying this …
de, il, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sapir Shapira, Daniela Yoeli, Yoni Leibner, Huibert D. Mansvelder et autres
The human brain's remarkable computational power enables parallel processing of vast information, integrating sensory inputs, memories, and emotions for rapid learning, adaptability, and creativity - far surpassing present-day artificial systems. These capabilities likely arise, in part, from the distinct properties of human …
il, nl, us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yonatan Leibner et autres
Larger dendritic diameter, increased conductance load at the soma, and differences in cable and ion channel properties enable faster signal propagation in human neocortical dendrites, preserving information processing speed.
hu, il
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yonatan Leibner et autres
Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents. We found that, in synaptically connected layer 2/3 pyramidal cells (L2/3 PCs), the delay in signal …
hu, il
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yoav Rubinstein, Maayan Moshkovitz, Itay Ottenheimer, Sapir Shapira et autres
During goal-directed behavior, animals select actions from a diverse repertoire of movements. Accurately quantifying this complex and high-dimensional repertoire is essential to uncovering the underlying rules that guide the behavior. Here, we developed a low-dimensional mathematical model that accurately reproduces the complete …
il, us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yoni Leibner et autres
Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents. We found that, in synaptically connected layer 2/3 pyramidal cells (L2/3 PCs), the delay in signal …
hu, il
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yoni Leibner et autres
Abstract Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents. We found that, in synaptically connected layer 2/3 pyramidal cells (L2/3 PCs), the delay in …
hu, il
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yoni Leibner et autres
Abstract Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents. We found that, in synaptically connected layer 2/3 pyramidal cells (L2/3 PCs), the delay in …
hu, il
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yoni Leibner et autres
Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents. We found that, in synaptically connected layer 2/3 pyramidal cells (L2/3 PCs), the delay in signal …
hu, il
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Yoav Rubinstein, Maayan Moshkovitz, Itay Ottenheimer, Sapir Shapira et autres
Abstract In goal-directed behavior animals select actions from a diverse repertoire of possible movements. Accurately quantifying the complete behavioral repertoire can uncover the underlying rules that guide such goal-directed behavior. However, these movements are usually complex, high-dimensional, and lead to various outcomes, …
il, us
(code pays fourni par la source)