Ralf A. Linker

P14.04.A CHARACTERISTIC FEATURES OF PATIENTS WITH AUTOIMMUNE DIFFERENTIAL DIAGNOSES FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL)

Ingo Beyer, Anna Fischl, Isabel Wiesinger, Do Hoon Lee et autres

Abstract BACKGROUND The diagnosis of this rare subtype of B-cell non-Hodgkin’s lymphoma limited to the CNS includes magnetic resonance imaging (MRI), tissue biopsy, cerebrospinal fluid (CSF) analysis and systemic staging. In imaging, PCNSL may resemble a number of differential diagnoses including autoimmune …

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Retinal ischemia due to different stages of atherosclerosis - insights from a retrospective study on central retinal artery occlusion

Felix Schlachetzki, Ina Feistenauer, Michael Ertl, Mustafa Kılıç et autres

BACKGROUND: Ischemic stroke (IS) and retinal ischemia (IR) share similar vascular risk factors, but differ in their risk for subsequent or recurrent stroke and therapeutic options. This study characterizes the cardiovascular risk profiles and magnitude of atherosclerosis of the carotid artery of …

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Teriflunomide Inhibits Human FOXP3 + Regulatory T Cell Function by Interference With Mitochondrial Respiration

Aleksandra Dyczko, Beatriz F. Côrte‐Real, Ibrahim Hamad, Ralf A. Linker et autres

T cells (Tregs) have been characterized with unique metabolic demands, preferentially relying on fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS). Several studies have indicated that Treg mitochondrial fitness is crucial for maintaining their stability and suppressive activity with an emphasis on …

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Ocrelizumab as first-line therapy in highly active relapsing-remitting multiple sclerosis

Tamar Kvartskhava, D. Freudenstein, Nicolas Sarmiento, Klemens Angstwurm et autres

In recent years, early use of highly effective disease modifying immunotherapies in relapsing-remitting multiple sclerosis (RRMS) demonstrated superior efficacy in preventing disability progression. For this study, we investigated ocrelizumab as first line therapy of RRMS in a monocentric, retrospective study. In our …

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A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individuals

C. Träger, D. Freudenstein, Simon Heckscher, Katja Dettmer et autres

BACKGROUND: Modulation of the gut microbiota composition has been suggested as a potential disease modifying therapy in immune-mediated diseases such as multiple sclerosis (MS). However, a conclusive mechanism linking gut microbiota modulation to peripheral immune responses has remained elusive so far. METHODS: …

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Pre-existing parasympathetic dominance seems to cause persistent heart rate slowing after 6 months of fingolimod treatment in patients with multiple sclerosis

Max J. Hilz, Carmen de Rojas-Leal, De-Hyung Lee, Ralf A. Linker et autres

PURPOSE: Vagomimetic fingolimod effects cause heart rate (HR) slowing upon treatment initiation but wear off with sphingosine-1-phosphate receptor downregulation. Yet, prolonged HR slowing may persist after months of fingolimod treatment. We evaluated whether cardiovascular autonomic modulation differs before and 6 months after …

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Eculizumab Use in Neuromyelitis Optica Spectrum Disorders

Marius Ringelstein, Susanna Asseyer, Gero Lindenblatt, Katinka Fischer et autres

BACKGROUND AND OBJECTIVES: Attack prevention is crucial in managing neuromyelitis optica spectrum disorders (NMOSDs). Eculizumab (ECU), an inhibitor of the terminal complement cascade, was highly effective in preventing attacks in a phase III trial of aquaporin-4 (AQP4)-IgG seropositive(+) NMOSDs. In this article, …

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P20.11.A DIAGNOSTIC DELAY OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL) MAY BE CAUSED BY INFLAMMATORY DIFFERENTIAL DIAGNOSES

Ingo Beyer, Martin Proescholdt, Isabel Wiesinger, Elisabeth Bumes et autres

Abstract BACKGROUND PCNSL is a rare extranodal subtype of B-cell non-Hodgkin lymphoma initially located in the central nervous system. It can only be finally diagnosed with tissue sampling. Therefore, tumor biopsy and staging examinations beforehand can delay diagnosis. Consequently, PCNSL at histological …

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Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Tania Kümpfel, Katrin Giglhuber, Orhan Aktaş, Ilya Ayzenberg et autres

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Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories

Catharina C. Groß, Andreas Schulte‐Mecklenbeck, Olga V. Steinberg, Timo Wirth et autres

One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical manifestations and progression trajectories. It still remains to be elucidated whether this heterogeneity is reflected by discrete immune signatures in the blood as a surrogate of disease pathophysiology. …

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Pre-existing parasympathetic dominance seems to account for heart rate slowingafter six months of Fingolimod-treatment in patients with multiple sclerosis

Max J. Hilz, Carmen de Rojas Leal, De-Hyung Lee, Ralf A. Linker et autres

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Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Tania Kümpfel, Katrin Giglhuber, Orhan Aktaş, Ilya Ayzenberg et autres

This manuscript presents practical recommendations for managing acute attacks and implementing preventive immunotherapies for neuromyelitis optica spectrum disorders (NMOSD), a rare autoimmune disease that causes severe inflammation in the central nervous system (CNS), primarily affecting the optic nerves, spinal cord, and brainstem. …

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