Peter C. L. Beverley

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Eleni Vatzia, Yan Zhang, Ehsan Sedhagat-Rostami, Veronica Martini et autres

Abstract Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TRM T cells, deuterium-enriched water was …

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Nicholas Avrion Mitchison. 5 May 1928 — 28 December 2022

Timothy J. Mitchison FRS, Peter C. L. Beverley

Avrion Mitchison, universally known as Av, made enormous contributions to the field of cellular immunity. Working under Peter Medawar FRS during his PhD in Oxford, Av made the crucial discovery that viable lymphocytes were responsible for rejection of grafts of foreign tissue, …

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Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells

Veronica Martini, Matthew D. Edmans, Simon Gubbins, Siddharth Jayaraman et autres

For the first time we have defined naïve, central memory, effector memory and differentiated effector porcine CD8 T cells and analyzed their distribution in lymphoid and respiratory tissues after influenza infection or immunization, using peptide-MHC tetramers of three influenza nucleoprotein (NP) epitopes. …

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Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells

Veronica Martini, Matthew D. Edmans, Simon Gubbins, Siddharth Jayaraman et autres

Abstract We defined naïve, central memory, effector memory and terminally differentiated porcine CD8 T cells and analyzed their phenotype in lymphoid and respiratory tissues after influenza infection or immunization using peptide-MHC tetramers of three influenza nucleoprotein (NP) epitopes. The hierarchy of response …

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Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Barbara Holzer, Pramila Rijal, Adam McNee, Basudev Paudyal et autres

In Fig 6, data points from Fig 6B BAL-4DPI graph were inadvertently reused in Fig 6B NS -1DPI instead of relevant data points when measuring virus titer in respective tissues.

Correction: Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs

Veronica Martini, Basudev Paudyal, Tiphany Chrun, Adam McNee et autres

Martini, V., B. Paudyal, T. Chrun, A. McNee, M. Edmans, E. Atangana Maze, B. Clark, A. Nunez, G. Dolton, A. Sewell, P. Beverley, R. MacLoughlin, A. Townsend, and E. Tchilian. 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective …

Defining the Role of Cellular Immune Signatures in Diagnostic Evaluation of Suspected Tuberculosis

Alice Halliday, Tereza Masonou, Mica Tolosa-Wright, Yanping Guo et autres

BACKGROUND: Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a significant challenge, particularly in high-income, low-incidence settings. Measurement of Mycobacterium tuberculosis (Mtb)-specific cellular immune signatures by flow cytometry discriminates active TB from latent TB infection (LTBI) in case-control studies; however, their …

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New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study

Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker et autres

Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain reaction (qRT-PCR)] and existing signatures for the detection of active …

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Additional data for the validation of candidate rule-out tests

Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker et autres

Additional analyses for diagnostic evaluation of serum protein signatures for detection of active tuberculosis using linear discriminant analysis

Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker et autres

Additional information on transcriptomic signatures used for validation studies

Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker et autres

Additional analyses for validation of transcriptomic signatures using linear discriminant analysis

Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker et autres