Umar F. Shahul Hameed

Cryo-EM structural analyses reveal plant-specific adaptations of the CDC48 unfoldase

Brandon Huntington, Anandsukeerthi Sandholu, Jun Wang, Junrui Zhang et autres

Targeted protein degradation through the CDC48 unfoldase enables the maintenance and rapid adaptation of proteomes across eukaryotes. However, the substantial differences among animals, fungi, and plants presumably drove extensive adaptation of CDC48-mediated degradation. Although animal and fungal CDC48 systems have shown structural …

Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase–receptor–substrate complex

Alexandra I. Vancea, Brandon Huntington, Wieland Steinchen, Christos G. Savva et autres

Strigolactones are plant hormones that regulate development and mediate interactions with soil organisms, including the germination of parasitic plants such as Striga hermonthica. Strigolactone perception by receptors initiates the degradation of transcriptional repressors via E3 ubiquitin ligases, but the mechanistic link between …

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Molecular Basis for Catalysis and Regulation of the Strigolactone Catabolic Enzyme CXE15

Umar F. Shahul Hameed, Aparna Balakrishna, Jian You Wang, Derry Alvarez et autres

Strigolactones (SLs) are pivotal plant hormones involved in developmental, physiological, and adaptive processes. SLs also facilitate symbiosis with arbuscular mycorrhizal fungi and trigger germination of root parasitic Striga plants. The carboxylesterase CXE15, recently identified as the SL catabolic enzyme in Arabidopsis thaliana, …

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Cryo-EM structural analyses reveal plant-specific adaptations of the CDC48 unfoldase

Brandon Huntington, Anandsukeerthi Sandholu, Jun Wang, Junrui Zhang et autres

Targeted protein degradation through the CDC48 unfoldase enables the maintenance and rapid adaptation of proteomes across eukaryotes. However, the substantial differences among animals, fungi, and plants presumably drove extensive adaptation of CDC48-mediated degradation. Although animal and fungal CDC48 systems have shown structural …

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Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14

Juan C. Moreno, Umar F. Shahul Hameed, Aparna Balakrishna, Abdugaffor Ablazov et autres

The natural growth regulator zaxinone increases the levels of the phytohormones strigolactone (SL) and abscisic acid in Arabidopsis (Arabidopsis thaliana) via unknown mechanisms. Here we demonstrate that part of the effect of zaxinone in Arabidopsis depend on the SL receptor DWARF14 (AtD14) …

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The dual function of EMB1579 in transcription and splicing governs tissue patterning in the Arabidopsis root meristem

Fatimah Aljedaani, Yanming Deng, Wouter Smet, Zeeshan Nasim et autres

In the root meristem of Arabidopsis, stem cell maintenance depends on the coordinated action of transcription factor networks. The transcriptional regulator EMBRYO DEFECTIVE 1579 (EMB1579), a protein that forms nuclear condensates, regulates plant growth. However, the molecular mechanisms through which it functions …

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Plant-specific adaptations of the CDC48 unfoldase

Brandon Huntington, Anandsukeerthi Sandholu, Junrui Zhang, Lingyun Zhao et autres

ABSTRACT Targeted protein degradation through the CDC48 unfoldase enables the maintenance and rapid adaptation of proteomes across eukaryotes. However, the profound differences between animals, fungi, and plants are expected to have led to a significant adaptation of the CDC48-mediated degradation. While animal …

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β-Carotene alleviates substrate inhibition caused by asymmetric cooperativity

Jieren Liao, Umar F. Shahul Hameed, Timothy D. Hoffmann, Elisabeth Kurze et autres

Abstract Enzymes are essential catalysts in biological systems. Substrate inhibition, once dismissed, is now observed in 20% of enzymes 1 and is attributed to the formation of an unproductive enzyme-substrate complex, with no structural evidence of unproductivity provided to date 1–6 . …

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Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase–receptor–substrate complex

Alexandra I. Vancea, Brandon Huntington, Wieland Steinchen, Christos G. Savva et autres

ABSTRACT Strigolactones (SLs) are a group of plant hormones that regulate various aspects of plant growth and development. Additionally, SLs exuded into the soil promote symbiotic relationships with arbuscular mycorrhizal fungi and stimulate the germination of parasitic plants such as Striga hermonthica …

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DWARF14 and KARRIKIN INSENSITIVE2 mediate signaling of the apocarotenoid zaxinone in Arabidopsis

Juan C. Moreno, Umar F. Shahul Hameed, Aparna Balakrishna, Abdugaffor Ablazov et autres

Abstract The natural growth regulator zaxinone increases the levels of the phytohormones strigolactone (SL) and abscisic acid in Arabidopsis ( Arabidopsis thaliana ) via unknown mechanisms. We demonstrate that parts of the effects of zaxinone in Arabidopsis depend on the SL receptor …

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Regulation of Arabidopsis polyamine acetylation by NATA1 and NATA2

Umar F. Shahul Hameed, Yann‐Ru Lou, Jian Yan, Francisco J. Guzmán‐Vega et autres

ABSTRACT Polyamines have vital functions in organisms, including bacteria, plants, and animals, with key roles in growth, development, and stress responses. Spermine/spermidine N 1-acetyl transferases (SSATs) regulate polyamine abundance by catalysing their N -acetylation, thereby reducing the pool of polyamines and producing …

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Comparison of outcome of conventional suture ligation versus ligasure vessel sealing in patients undergoing total thyroidectomy for multinodular goiter.

Ahmed Raza Hameed, Ahmed Siddique Ammar, Mishal Saleem, Hamza Naeem et autres

Objective: To compare the results of Ligasure versus conventional suture ligation for thyroidectomy for multinodular goiter in terms of mean operative time and post-operative drain output volume. Study Design: Comparative Prospective study. Setting: Department of General Surgery, Mayo Hospital Lahore. Period: 1st …

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