Laura Díaz Martin

Exercise Intervention in Patients with Metabolic Syndrome and Renal Disease: A Prospective Study (EXRED)

Olav Rivero Martín, Raúl Morales Febles, Patricia Isabel Delgado Mallén, Elia Reseghetti et autres

INTRODUCTION: In patients with chronic kidney disease (CKD) of diverse causes, obesity and metabolic syndrome (MS) accelerate disease progression. Therapeutic exercise could be effective in treating obesity and MS in patients with CKD. However, the evidence in this area is limited. The …

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#1867 Spanish renal health cohort: Mulagua study

Sergio Luis Lima, Raúl Morales Febles, Laura Díaz Martin, Talía Cury et autres

Abstract Background Chronic kidney disease (CKD) is a serious Health problem. It is the eighth leading cause of death worldwide, is going to be the fifth in 2040, and the second in 2100. CKD is a first-order disease, carrying a high burden …

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#3248 Adjustment of glomerular filtration rate by BSA: an unnecesary error in estimating renal function

Sergio Luis Lima, Patricia Isabel Delgado Mallén, Beatriz Escamilla Cabrera, Sara Estupiñan Torres et autres

Abstract Background and Aims Glomerular filtration rate (GFR) is the main index of renal function in clinical practice and research. GFR is used to assess renal function at fixed points and to check the evolution of renal disease evolution over time, the …

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#119 Exercise intervention in patients with metabolic syndrome and renal disease: a prospective study (EXRED)

Olav Rivero Martín, Raúl Morales Febles, Patricia Isabel Delgado Mallén, Elia Reseghetti et autres

Abstract Background and Aims In patients with chronic kidney disease (CKD) of diverse causes, obesity and metabolic syndrome (MS) accelerate disease progression. Therapeutic exercise could be effective in treating obesity and MS in patients with CKD. However, the evidence in this area …

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#3314 Estimated GFR in clinical practise: rolling the dice

Sergio Luis Lima, Patricia Isabel Delgado Mallén, Beatriz Escamilla Cabrera, Sara Estupiñan Torres et autres

Abstract Background and Aims Renal function is evaluated in clinical practice by creatinine- and/or cystatin-C-based formulas. Several studies reported that cystatin-C-based formulas improves the performance of those based on creatinine. More than 50 formulas have been published in the last 70 years, …

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#395 Diabetic nephropathy evaluation in an non-genotypic animal model of type 2 diabetes

Silvia Teixidó-Trujillo, María Fernanda Toniolo, Sergio Luis Lima, Laura Díaz Martin et autres

Abstract Background and Aims The pathogenesis of diabetic nephropathy (DN) is not completely known. This could be related with a lack of pre-clinical models. Current animal models, mostly genotypic and monogenic, do not fully reflect diabetic organ damage. In previous studies of …

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#5 The adjustment of GFR by body surface area: a misleading procedure in trials focused on weight reduction and GFR changes

Elia Reseghetti, Olav Rivero Martín, Raúl Morales Febles, Patricia Isabel Delgado Mallén et autres

Abstract Background and Aims controversies exist on the benefits of estimated GFR (eGFR) by formulas (more uncertain) of gold standards (more accurate). Another problem is the adjustment of GFR for body surface area (BSA). The scientific background of the adjustment is weak …

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Role of obesity and estrogen deficiency in non‑alcoholic fatty liver disease: Insights from a mouse model

Aarón Afonso-Alí, Jano Dicroce‐Giacobini, Silvia Teixidó-Trujillo, Esteban Porrini et autres

The prevalence of non‑alcoholic fatty liver disease (NAFLD) increases in post‑menopausal women, driven by obesity and metabolic syndrome (MS). However, the pathogenesis of this interaction remains poorly understood. The present study investigated the interplay between obesity, menopause and NAFLD in a C57BL6/J …

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Renal functional reserve in living kidney donors

Ana González Rinne, Cristian Acosta Sørensen, Elia Reseghetti, Yaiza Rivero Viera et autres

ABSTRACT Background Factors associated with renal functional reserve (RFR)—presence or absence—are not completely clear and remain underinvestigated. Methods In this observational study, we evaluated the characteristics associated with the presence or absence of RFR in healthy subjects—living kidney donors—before donation. Renal function …

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Obesity and Low Birthweight: A Synergistic Pathway to Kidney Injury

Jano Dicroce‐Giacobini, Aarón Afonso-Alí, Silvia Teixidó-Trujillo, José A. Pérez et autres

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Efficacy of the Once-Daily Tacrolimus Formulation LCPT Compared to the Immediate-Release Formulation in Preventing Early Post-Transplant Diabetes in High-Risk Kidney Transplant Patients: A Randomized, Controlled, Open-Label Pilot Study (EUDRACT: 2017-000718-52)

Armando Torres, Concepción Rodríguez-Adanero, Constantino Fernández Rivera, Domingo Marrero Miranda et autres

Background/Objectives: Post-transplant diabetes mellitus (PTDM) and prediabetes (PreDM) are common after renal transplantation and increase the risk of cardiovascular events and mortality. Compared to immediate-release tacrolimus (IR-Tac), the LCPT formulation, with delayed absorption, offers higher bioavailability and a smoother time–concentration curve, potentially …

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Impact and consequences of the error of estimated GFR in patients with heart failure

Pablo Jorge‐Pérez, Martín J. García‐González, Marta María Martín-Cabeza, Natalia Negrín‐Mena et autres

Heart failure is a highly prevalent disease, which courses with frequent readmissions, mainly by Acute Heart Failure (AHF). Reduced renal function is associated with increased mortality in patients with HF. Therefore, an accurate and precise evaluation of renal function in patients with …

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