Lorena Usero

The ER stress inducer ABTL0812/ibrilatazar potentiates standard chemotherapies and mitigates the immunosuppressive microenvironment in preclinical models of pancreatic cancer

Lorena Usero, Guillermo Yoldi, Claudia Faundez-Vidiella, Nora Diéguez-Martínez et autres

Assessment of Human SARS CoV-2-Specific T-Cell Responses Elicited In Vitro by New Computationally Designed mRNA Immunogens (COVARNA)

Ignasi Esteban, Carmen Pastor-Quiñones, Lorena Usero, Elena Aurrecoechea et autres

The COVID-19 pandemic has brought significant changes and advances in the field of vaccination, including the implementation and widespread use of encapsidated mRNA vaccines in general healthcare practice. Here, we present two new mRNAs expressing antigenic parts of the SARS-CoV-2 spike protein …

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The Combination of an mRNA Immunogen, a TLR7 Agonist and a PD1 Blocking Agent Enhances In-Vitro HIV T-Cell Immune Responses

Lorena Usero, Lorna Leal, Carmen Elena Gómez, Laia Miralles et autres

The development of new strategies to achieve a functional cure for HIV remains a priority. We tested a novel HIV therapeutic vaccine using unmodified mRNA (TMEP-B) and mRNA modified by 1-methyl-3'-pseudouridylyl (TMEP-Bmod) expressing both a multiepitopic sequences from Gag, Pol, and Nef …

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Feasibility of using monocyte-derived dendritic cells obtained from cryopreserved cells for DC-based vaccines

Lorena Usero, Laia Miralles, Ignasi Esteban, Carmen Pastor-Quiñones et autres

The study of the effect of cryopreservation on the functionality of monocyte-derived dendritic cells (MDDCs) and dendritic cells (DCs) is essential for their use in different clinical applications such as DCs-based vaccines. Its full maturation and its optimal functionality are crucial for …

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Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen

Carmen Elena Gómez, Beatriz Perdiguero, Lorena Usero, Laura Marcos-Villar et autres

Development of a vaccine against HIV remains a major target goal in the field. The recent success of mRNA vaccines against the coronavirus SARS-CoV-2 is pointing out a new era of vaccine designs against pathogens. Here, we have generated two types of …

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New Paradigm in NKT Cell Antigens: MCS‐0208 (2‐(Hydroxymethyl)phenylthio‐phytoceramide) – an Aryl‐Phytoceramide Compound with a Single Hydroxyl Group Stimulates NKT Cells

Roser Borràs‐Tudurí, Anna Alcaide, Sandrine Aspeslag, Lorena Usero et autres

Natural Killer T (NKT) cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208, an unprecedented arylthioether-phytoceramide able to induce potent invariant NKT (iNKT) cell activation, notably when tested in …

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In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?

Ignasi Esteban, Carmen Pastor-Quiñones, Lorena Usero, Montserrat Plana et autres

Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken …

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Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection

Élodie Picarda, Séverine Bézie, Lorena Usero, Jason Ossart et autres

To reduce the use of non-specific immunosuppressive drugs detrimental to transplant patient health, therapies in development aim to achieve antigen-specific tolerance by promoting antigen-specific regulatory T cells (Tregs). However, identification of the natural antigens recognized by Tregs and the contribution of their …

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Interleukin-13 Pathway Alterations Impair Invariant Natural Killer T-Cell–Mediated Regulation of Effector T Cells in Type 1 Diabetes

Lorena Usero, Ana Sánchez, Eduarda Pizarro, Cristina Xufré et autres

Many studies have shown that human natural killer T (NKT) cells can promote immunity to pathogens, but their regulatory function is still being investigated. Invariant NKT (iNKT) cells have been shown to be effective in preventing type 1 diabetes in the NOD …

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Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

Paula Pifarré, María Gutièrrez‐Mecinas, Judith Prado, Lorena Usero et autres

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Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients

Cristina Xufré, Manuela Costa, Carme Roura‐Mir, Eva Codina-Busqueta et autres

Reported alterations in T(reg) cells from type 1 diabetes (T1D) patients led us to a revision of their phenotypical features compared with controls. A fine cytometric analysis was designed for their characterization, using a panel of markers including FOXP3, CTLA4, glucocorticoid-induced TNFR …

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