Florian Posch

Comparison of outcomes after DA ‐ EPOCH ‐R or GMALL high‐intensity therapy for front‐line treatment of Burkitt lymphoma: A retrospective cohort

Eduard Schulz, Florian Posch, Kristina Friedrich, Peter Neumeister et autres

In this retrospective cohort of adult Burkitt lymphoma, DA-EPOCH-R showed no signal of inferior survival or relapse risk compared with GMALL-based high-intensity therapy. Outcomes were driven mainly by established prognostic factors, particularly age, advanced stage and Burkitt lymphoma International Prognostic Index.

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Low extracellular vesicle–associated tissue factor activity in patients with persistent lupus anticoagulant and a history of thrombosis

Florian Posch, Silvia Koder, Cihan Ay, J. Thaler et autres

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Hemostatic Biomarkers and Venous Thromboembolism Are Associated With Mortality and Response to Chemotherapy in Patients With Pancreatic Cancer

Theresa Schramm, Gerald Prager, Cihan Ay, Ingrid Pabinger et autres

Objective: Pancreatic cancer activates coagulation and increases risk of venous thromboembolism (VTE). We aimed at characterizing the association of hemostatic biomarkers and VTE with mortality and chemotherapy response. Approach and Results: Pancreatic cancer patients (N=145) were included in a prospective, observational cohort …

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Altered immune responses to mRNA vaccination against SARS-COV-2 are characterized by an impaired cross-talk between humoral and T-cellular immune compartments in patients with hematologic diseases

Stefan Hatzl, Florian Posch, Eduard Schulz, Barbara Uhl et autres

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Prevalence and risk factors for asymptomatic venous thromboembolism in patients with primary brain tumors

Viktoria Nemecz, Reinhard Bernd Raggam, Tadeja Urbanic-Purkart, Kujtim Bytyqi et autres

= 0.04). According to time-to-VTE regression analyses, higher D-dimer, Galectin-3 levels, and von Willebrand factor activity were predictive of increased VTE risk. This study revealed a high prevalence of asymptomatic LE-DVT in patients with primary brain tumors and found that galectin-3 may …

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Anticoagulation Monitoring Strategies During Extracorporeal Membrane Oxygenation (ECMO) Therapy – Differences Between Simultaneously Obtained Coagulation Tests: A Retrospective Single-Center Cohort Study

Alexander Christian Reisinger, Nikolaus G. Schneider, Marco Koellinger, Stefan Hatzl et autres

IntroductionDuring extracorporeal membrane oxygenation (ECMO) systemic anticoagulation with unfractionated heparin (UFH) is standard-of-care. However, there is uncertainty regarding optimal anticoagulation monitoring strategies.MethodsWe retrospectively investigated venovenous and venoarterial ECMO patients at the medical ICUs at the Medical University of Graz, Austria. We analyzed …

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Prognostic Impact of Gait Speed, Muscle Strength and Muscle Mass in Chronic Heart Failure—A Prospective Cohort Study

Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik et autres

Abstract Aims Heart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) and appendicular skeletal muscle index (ASMI) on cardiovascular outcomes in a prospective HF …

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Neoadjuvant atezolizumab in combination with dual HER2 blockade plus epirubicin in women with early HER2-positive breast cancer: the randomized phase 2 ABCSG-52/ATHENE trial

Gabriel Rinnerthaler, Daniel Egle, Rupert Bartsch, Clemens A. Schmitt et autres

The role of anthracyclines in the treatment of early breast cancer (EBC) is increasingly being challenged, especially in de-escalation strategies. However, owing to their immunogenic effects, anthracyclines are promising combination partners with immunotherapies. In the randomized phase 2 trial ABCSG-52 (EudraCT no. …

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Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV: a systematic review and network meta-analysis of randomized controlled trials

Stefan Hatzl, Florian Posch, Laura Scholz, Christina Geiger et autres

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection in people living with HIV (PWH) who have low CD4 counts. Despite its side effects, trimethoprim-sulfamethoxazole (TMP-SMX) is currently considered the primary treatment for PCP. OBJECTIVES: The objectives of this study are …

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Prognostic impact of targetable driver alterations in resected early-stage lung cancer

Angelika Terbuch, Selma Konjić, Verena Schlintl, Gudrun Absenger et autres

Background: Apart from ALK fusions and the common EGFR mutations, targetable molecular alterations are irrelevant for adjuvant treatment decision making in early-stage non-small cell lung cancer (NSCLC). This retrospective analysis aimed to investigate if there is a difference in recurrence-free survival in …

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Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism

Paul Gressenberger, Florian Posch, Gabriel Adelsmayr, Eszter Nagy et autres

Lipoprotein (a) [Lp(a)] is suspected to have antifibrinolytic effects, however, its relevance for the severity of venous thromboembolic events remains unclear. We studied the association of Lp(a) levels with thrombus load in pulmonary embolism (PE). 90 patients (40% female, median age 70 …

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Invasive Pulmonary Aspergillosis in Critically Ill Patients with Hantavirus Infection, Austria

Stefan Hatzl, Laura Scholz, Florian Posch, Philipp Eller et autres

We investigated a cohort of 370 patients in Austria with hantavirus infections (7.8% ICU admission rate) and detected 2 cases (cumulative incidence 7%) of invasive pulmonary aspergillosis; 1 patient died. Hantavirus-associated pulmonary aspergillosis may complicate the course of critically ill patients who …