Kathleen Maksimowicz‐McKinnon

Phase III/IV, Randomized, Fifty‐Two–Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus

Ellen M. Ginzler, Beulah Ji, Saira Z. Sheikh, Jennifer Gilbride et autres

OBJECTIVE: Enrollment of patients of Black African ancestry with systemic lupus erythematosus (SLE) in phase II and phase III of the belimumab trials was not reflective of the racial distribution observed in the lupus population. This study was undertaken to assess the …

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Infections in Vasculitis: Can We Create an Epidemic of Change?

Gretchen Santana Cepero, John E. McKinnon, Kathleen Maksimowicz‐McKinnon

In the article entitled "Prevalence, Predictors, and Prognosis of Serious Infections in Takayasu Arteritis: A Cohort Study" by Misra and colleagues in this issue of The Journal of Rheumatology, the authors examine the incidence of serious infections in a Takayasu arteritis (TA) …

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Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Gonzalo Borrego‐Yaniz, Lourdes Ortiz‐Fernández, Adela Madrid-Paredes, Martin Kerick et autres

Background Giant cell arteritis is an age-related vasculitis that mainly affects the aorta and its branches in individuals aged 50 years and older. Current options for diagnosis and treatment are scarce, highlighting the need to better understand its underlying pathogenesis. Genome-wide association …

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POS0712 YEAR-4 OBSERVATIONAL FOLLOW-UP OF BELIMUMAB SAFETY (MORTALITY AND MALIGNANCIES) IN PATIENTS WITH SLE WHO COMPLETED A PHASE 4, 52-WEEK, RANDOMISED, DOUBLE-BLIND PLACEBO-CONTROLLED SAFETY STUDY

Saira Z. Sheikh, M. Scheinberg, James Cheng‐Chung Wei, Dana Tegzová et autres

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Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature

Patrick Coit, Xiavan Roopnarinesingh, Lourdes Ortiz‐Fernández, Kathleen Maksimowicz‐McKinnon et autres

Abstract Objectives Epigenetic dysregulation plays an important role in the pathogenesis of lupus, a systemic autoimmune disease characterized by autoantibody production. Lupus T cells demonstrate aberrant DNA methylation patterns dominated by hypomethylation of interferon-regulated genes. The objective of this study was to …

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Safety and tolerability of hydroxychloroquine in health care workers and first responders for the prevention of COVID-19: WHIP COVID-19 Study

John E. McKinnon, Dee Dee Wang, Marcus Zervos, Matt Saval et autres

BACKGROUND: Health care workers (HCW) are among the highest risk groups for acquisition of COVID-19 because of occupational exposures. The WHIP COVID-19 Study aimed to evaluate the safety and efficacy of hydroxychloroquine (HCQ) as chemoprophylaxis for SARS-CoV-2 infection in this population. METHODS: …

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1507 The relationship between DNA methylation patterns and disease activity in a longitudinal multi-ancestral cohort of lupus patients

Patrick Coit, Lourdes Ortiz‐Fernández, Emily E. Lewis, W. Joseph McCune et autres

Background Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis of DNA methylation in lupus patients and assessed epigenetic changes over time and across disease activity status. Combining genetic and epigenetic analyses, we also examined ancestry-specific DNA …

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The role of tocilizumab therapy in critically ill patients with severe acute respiratory syndrome coronavirus 2

Zaid Saffo, Weixia Guo, Kylie Springer, Kathleen Maksimowicz‐McKinnon et autres

CONTEXT: Tocilizumab (TCZ), an interleukin-6 (IL-6) receptor antagonist, has been approved for use in rheumatoid arthritis and cytokine storm syndrome (CSS) associated with chimeric antigen receptor T cells treatment. Although TCZ is currently utilized in the treatment of critically ill coronavirus 2019 …

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Phase III / IV , Randomized, Fifty‐Two –Week Study of the Efficacy and Safety of Belimumab in Patients of Black African Ancestry With Systemic Lupus Erythematosus

Ellen M. Ginzler, Luiz Sergio Guedes Barbosa, David D’Cruz, Richard Furie et autres

OBJECTIVE: Enrollment of patients of Black African ancestry with systemic lupus erythematosus (SLE) in phase II and phase III of the belimumab trials was not reflective of the racial distribution observed in the lupus population. This study was undertaken to assess the …

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Subclinical CMV viremia is associated with increased nosocomial infections and prolonged hospitalization in patients with systemic autoimmune diseases

Kathleen Maksimowicz‐McKinnon, Junying Zhou, Jenna Hudy, Sara Hegab et autres

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Interstitial Lung Disease in Patients with Anti-Ro52 Antibody: A Case Report

ADAM A KUDIRKA, A.M. Abdul Hameed, Krishna Thavarajah, Kathleen Maksimowicz‐McKinnon et autres

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Mortality and adverse events of special interest with intravenous belimumab for adults with active, autoantibody-positive systemic lupus erythematosus (BASE): a multicentre, double-blind, randomised, placebo-controlled, phase 4 trial

Saira Z. Sheikh, Morton Scheinberg, James Cheng‐Chung Wei, Dana Tegzová et autres

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