Alessandro Faroni

Electromagnetic exposure changes human Schwann cell motility and transcriptomic profile of hearing-loss-related genes

Tasnim Mohamed, Alessandra Colciago, Alessandro Faroni, Adam J. Reid et autres

Schwann cells (SCs) are glial cells of the peripheral nervous system with functional plasticity in physio-pathological conditions, such as injury and oncotransformation. Interestingly, human SCs seem to develop, mature, and respond differently to other species to environmental challenges. Recently, concerns have been …

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Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Liam A. McMorrow, Jared McSweeney, Alessandro Faroni, Aline F. Miller et autres

Autograft, the gold standard in nerve reconstruction, outperforms the alternatives of acellular allograft/nerve conduits likely due to the transplanted Schwann cell population within. The stromal vascular fraction (SVF) is a heterogenous cell isolate, that may improve nerve regeneration outcomes when transplanted at …

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Acetylcholine muscarinic M2 receptor maintains human Schwann-like adipose-derived phenotype in the absence of differentiating medium

Roberta Piovesana, Alessandro Faroni, Ada Maria Tata, Adam J. Reid

Human adipose-derived stem cells (ASCs), differentiated in vitro towards Schwann-like phenotype (hdASCs), have been suggested as an alternative source of Schwann cells (SCs). However, although they seem a good alternative, their differentiation is unstable, losing their SC-like phenotype following growth factor withdrawal. …

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Biochemical functionalization of graphene oxide for directing stem cell differentiation

Andrea Francesco Verre, Alessandro Faroni, Maria Iliuţ, Claudio Silva et autres

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Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure

Alessandra Colciago, Matteo Audano, Veronica Bonalume, Valentina Melfi et autres

Hearing loss (HL) is the most common sensory disorder in the world population. One common cause of HL is the presence of vestibular schwannoma (VS), a benign tumor of the VIII cranial nerve, arising from Schwann cell (SC) transformation. In the last …

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Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity

Veronica Bonalume, Lucia Caffino, Luca F. Castelnovo, Alessandro Faroni et autres

Key points GABA depolarized sural nerve axons and increased the electrical excitability of C‐fibres via GABAA receptor. Axonal excitability responses to GABA increased monotonically with the rate of action potential firing. Action potential activity in unmyelinated C‐fibres is coupled to Na‐K‐Cl cotransporter …

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Cross‐talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors

Jasdeep Saini, Alessandro Faroni, Adam J. Reid, Vincent Mouly et autres

Neuromuscular junction (NMJ) research is vital to advance the understanding of neuromuscular patho-physiology and development of novel therapies for diseases associated with NM dysfunction. In vivo, the micro-environment surrounding the NMJ has a significant impact on NMJ formation and maintenance via neurotrophic …

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Graphene Oxide Substrate Promotes Neurotrophic Factor Secretion and Survival of Human Schwann‐Like Adipose Mesenchymal Stromal Cells

Steffan H. Llewellyn, Alessandro Faroni, Maria Iliuţ, Cian Bartlam et autres

Mesenchymal stromal cells from adipose tissue (AD-MSCs) exhibit favorable clinical traits for autologous transplantation and can develop 'Schwann-like' phenotypes (sAD-MSCs) to improve peripheral nerve regeneration, where severe injuries yield insufficient recovery. However, sAD-MSCs regress without biochemical stimulation and detach from conduits under …

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The angiogenic potential of CD271+ human adipose tissue-derived mesenchymal stem cells

Richard J. P. Smith, Alessandro Faroni, James R. Barrow, Jamie Soul et autres

BACKGROUND: Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mesenchymal stem cells (AD-MSCs) improves graft survival-however, AD-MSCs represent a heterogeneous …

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Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration: effects of cholinergic stimulation

Adam J. Reid, Roberta Piovesana, Alessandro Faroni, AdaMaria Tata

Schwann-like adipose-derived stem cells and nerve injury: Peripheral nerve injuries (PNIs) are a common clinical problem usually as a consequence of trauma. Despite optimal surgical management, PNI has a lifelong impact on function and wellbeing of the patient. The peripheral nervous system …

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Effects mediated by the α7 nicotinic acetylcholine receptor on cell proliferation and migration in rat adipose-derived stem cells

Marta Pernarella, Roberta Piovesana, Carlo Matera, Alessandro Faroni et autres

Adipose-derived stem cells (ASCs) are an attractive source for regenerative medicine as they can be easily isolated, rapidly expandable in culture and show excellent in vitro differentiation potential. Acetylcholine (ACh), one of the main neurotransmitters in central and peripheral nervous systems, plays …

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Peripheral nerve regeneration following injury is altered in mice lacking P2X7 receptor

Valerio Magnaghi, Sarah L. Martin, Patrick William Smith, Luke B. Allen et autres

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