Kingston H. G. Mills

Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis

Anna E. Ledwith, Hannah Prendeville, Cian JH. Horneck Johnston, Stephen P. Cunningham et autres

Obesity is associated with profound immune dysregulation, driving chronic inflammation while compromising host defense against tumors. While trained immunity can enhance innate effector functions, it has thus far required parenteral administration of microbial ligands. Here, we show that incorporating a yeast-derived β-glucan …

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Mechanisms of natural and vaccine-induced immunity to Bordetella pertussis

Lisa Borkner, Caroline E. Sutton, Sreeram Udayan, Seyed Davoud Jazayeri et autres

Bordetella pertussis causes whooping cough (pertussis), a respiratory infectious disease that is resurgent despite high vaccine coverage. Research on the mechanisms of immunity to B. pertussis have demonstrated protective roles for innate immune cells, antibodies and T cells in immunity induced by …

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Blood vessel-associated inflammatory microglia and astrocytes are associated with molecular and cellular markers of blood-brain barrier permeability in neonatal mice infected with the respiratory pathogen Bordetella pertussis

Eoin O′Neill, Marina A. Lynch, Kingston H. G. Mills

Severe infection with the respiratory pathogen Bordetella pertussis during infancy has been associated with neurological complications, but the underlying mechanisms are not fully understood. Here we examined the impact of infection of neonatal mice with B. pertussis on the blood-brain barrier (BBB) …

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Tissue resident memory T cells in respiratory infections

Karen N McCarthy, Kingston H. G. Mills

PURPOSE OF REVIEW: We review the latest evidence that respiratory tissue resident memory T (T RM ) cells are key to local and immediate adaptive immunity to bacterial and viral infections of the respiratory tract and the implication for the design of …

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Impact of innate immune activation on T cell dynamics and functional recovery following traumatic brain injury

Sahil Threja, Nathan Ryzewski Strogulski, Janeen Laabei, Gloria Vegliante et autres

Background Traumatic brain injury (TBI) initiates a rapidly evolving neuroinflammatory response; however, the temporal relationship between early innate immune activation, T cell polarization, and neurobehavioural recovery remains poorly understood. Here, we hypothesize that interleukin-1β (IL-1β) is a critical upstream mediator that polarizes …

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Author Correction: Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice

Seyed Davoud Jazayeri, Lisa Borkner, Caroline E. Sutton, Kingston H. G. Mills

In the version of the article initially published, in the first paragraph of the Results, chloramphenicol was described as a “beta-lactam antibiotic” but this should have read “broad-spectrum antibiotic”. This error has been corrected in the HTML and PDF versions of the …

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Respiratory immunization using antibiotic-inactivated Bordetella pertussis confers T cell-mediated protection against nasal infection in mice

Seyed Davoud Jazayeri, Lisa Borkner, Caroline E. Sutton, Kingston H. G. Mills

The Gram-negative bacterium Bordetella pertussis causes whooping cough (pertussis), a severe respiratory disease, especially in young children, which is resurgent despite high vaccine coverage. The current acellular pertussis vaccine prevents severe disease but does not prevent nasal infection with B. pertussis. This …

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IL-17-secreting γδ T-cell-driven Siglec-F+ neutrophils mediate lung pathology in emphysema

Kingston H. G. Mills

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Acellular Pertussis Vaccines Induce CD8 + and CD4 + Regulatory T Cells That Suppress Protective Tissue‐Resident Memory CD4 + T Cells, in Part via IL‐10

Caitlín Ní Chasaide, Pauline Schmitt, Béré Diallo, Lisa Borkner et autres

ABSTRACT Tissue‐resident memory T (T RM ) cells play a key role in sustained protective immunity against Bordetella pertussis infection of the nasal mucosa. Current alum‐adjuvanted acellular pertussis (aP) vaccines protect against severe pertussis disease but fail to prevent nasal infection with …

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Highlights of the 14th International Bordetella Symposium

Kevin Munoz Navarrete, Kathryn M. Edwards, Kingston H. G. Mills, Jana Kamanová et autres

ABSTRACT Pertussis, or whooping cough, is a highly contagious and acute respiratory illness caused primarily by the gram-negative coccobacillus Bordetella pertussis . Despite near-universal vaccination, pertussis remains one of the least-controlled vaccine-preventable infectious diseases. Since 2023, pertussis incidence has been rising, and …

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BNT162b2 mRNA vaccination attenuates innate immune function in humans

Sarah A. Connolly, Aaron M. Walsh, Anna E. Ledwith, Karen Mc Carthy et autres

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Neonatal infection with Bordetella pertussis promotes autism-like phenotypes in mice

Eoin O′Neill, Lucy Curham, Caitlín Ní Chasaide, Gavin McManus et autres

Summary Autism spectrum disorder (ASD) has been linked with infections early in life. Here we demonstrate that the infection of neonatal mice with the respiratory pathogen Bordetella pertussis leads to neuroinflammation, neurodevelopmental defects, and ASD-like behaviors. Following the respiratory challenge of neonatal …

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