Maxime Robin

Special Issue “New Drugs Regulating Cytoskeletons in Human Health and Diseases”

Gilles Breuzard, Maxime Robin, Hervé Kovacic

Cytoskeletons are dynamic and multifunctional cellular frameworks composed of microtubules, actin filaments, and intermediate filaments [...].

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Flavonoid-mediated modulation of Tau protein: Implications for targeted therapeutics and clinical relevance in Tau-related disorders

Rayane Hedna, Emmanuelle T. Relave, Maxime Robin, Hervé Kovacic et autres

Tau protein displays a key role in promoting tubulin assembly and microtubule stabilization. Alterations in Tau expression have been implicated in many pathologies, including neurodegenerative disorders and, more recently, certain forms of cancer such as glioblastoma, where aberrant Tau expression has been …

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Nouvelles normes d’information sur la durabilité. Vers des entreprises plus responsables ?

Maxime Robin, Samuel Sponem

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Therapeutic Contribution of Tau-Binding Thiazoloflavonoid Hybrid Derivatives Against Glioblastoma Using Pharmacological Approach in 3D Spheroids

Emmanuelle T. Relave, Rayane Hedna, Attilio Di Maio, François Devred et autres

Growing evidence has unveiled the pathological significance of Tau in many cancers, including the most aggressive and lethal brain tumor glioblastoma multiform (GBM). In this regard, we have recently examined the structure–activity relationship of a new series of seventeen 2-aminothiazole-fused to flavonoid …

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Prevalence and clinical value of autoantibodies directed against lysobisphosphatidic acid in antiphospholipid syndrome

Mathilde Lambert, Maxime Robin, Lucie Munier, Abdou Beziane et autres

OBJECTIVES: To assess the prevalence and clinical significance of autoantibodies against lysobisphophatidic acid (aLBPA) in patients with APS. METHODS: We conducted a retrospective analysis involving 91 patients with persistent conventional aPLs: 60 patients with at least one clinical event of APS (symptomatic …

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3,5-Dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and MAFLD in Leptin-Deficient ob/ob Mice

Stéphanie Gaigé, Anne Abysique, Rym Barbouche, Alain Tonetto et autres

Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities, including anti-diabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites …

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3,5-dimethyl-2,4,6-trimethoxychalcone Lessens Obesity and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Leptin-Deficient ob/ob Mice

Stéphanie Gaigé, Anne Abysique, Rym Barbouche, Attilio Di Maio et autres

Chalcones constitute an important group of natural compounds abundant in fruits and comestible plants. They are a subject of increasing interest because of their biological activities including antidiabetic and anti-obesity effects. The simple chalcone structural scaffold can be modified at multiple sites …

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Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio, Hamza Olleik, Elise Courvoisier‐Dezord, Sophie Guillier et autres

The development of new and effective antimicrobial compounds is urgent due to the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules, but their activity and selectivity have to be increased. Based on previous aurone potency, we designed …

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Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio, Hamza Olleik, Elise Courvoisier‐Dezord, Sophie Guillier et autres

The development of new and effective antimicrobial compounds is an urgent need with the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules but their activity and selectivity have to be increased. Based on previous aurone potency, we …

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2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

Rayane Hedna, Attilio Di Maio, Maxime Robin, Diane Allegro et autres

Tau protein has been described for several decades as a promoter of tubulin assembly into microtubules. Dysregulation or alterations in Tau expression have been related to various brain cancers, including the highly aggressive and lethal brain tumor glioblastoma multiform (GBM). In this …

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Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma

Rayane Hedna, Hervé Kovacic, Alessandra Pagano, Vincent Peyrot et autres

Despite being extensively studied for several decades, the microtubule-associated protein Tau has not finished revealing its secrets. For long, Tau has been known for its ability to promote microtubule assembly. A less known feature of Tau is its capability to bind to …

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Hydra bioassay for the evaluation of chlordecone toxicity at environmental concentrations, alone or in complex mixtures with dechlorinated byproducts: experimental observations and modeling by experimental design

Xavier Moreau, Magalie Claeys‐Bruno, Jean-Pascal Andraud, Hervé Macarie et autres

Abstract In chlordecone (CLD) contaminated soils of the French West Indies, if microbial remediation or a physicochemical remediation process, e.g., in situ chemical reduction, is implemented, concentrations of degradation byproducts, such as hydrochlordecones, are expected to increase in the ecosystems. To study …

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