Benjamin McCullough

A Non-Invasive Approach to Tremor Control: A Phase I/II Prospective Clinical Trial of Modern Stereotactic Radiosurgery

Evan Thomas, Harrison C. Walker, Ashley Anderson, Erik H. Middlebrooks et autres

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

Adam Duxfield, Rebecca Garnham, Esme Hutton, Adam Dowle et autres

Abstract Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cancer have failed to elicit durable clinical responses. PCa progression is driven by transcriptional networks regulated by …

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Connectomic-guided stereotactic radiosurgery thalamotomy for tremor: a patient-specific approach to enhance outcomes

Erik H. Middlebrooks, Vishal Patel, Richard A. Popple, Harrison C. Walker et autres

OBJECTIVE: Stereotactic radiosurgery (SRS) is an effective treatment for refractory tremor. However, the lack of reliable patient-specific targeting biomarkers leads to varying outcomes. Although connectomic-based targeting is commonly used in deep brain stimulation, its application in SRS is limited. This study aimed …

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Frameless, Virtual Cone Linac-based Stereotactic Radiosurgery for Essential & Parkinsonian Tremor: A Phase I/II Prospective Clinical Trial (S35.001)

Evan Thomas, Harrison C. Walker, Erik H. Middlebrooks, Benjamin McCullough et autres

OBJECTIVE: To evaluate the safety and efficacy of a modern linear accelerator with non-invasive thermoplastic mask-based immobilization as an alternative treatment for medically refractory tremor. BACKGROUND: Essential and Parkinsonian tremors are prevalent movement disorders impacting millions globally. Although Gamma Knife radiosurgery remains …

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IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway

Alex Bainbridge, Scott C. Walker, Joseph A. Smith, Kathryn Patterson et autres

Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification and expression of AR splice variants, demonstrating that AR remains a key therapeutic target in advanced disease. …

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Anti-Angiogenesis, Gene Therapy, and Immunotherapy in Malignant Gliomas

Paula Province, Alexis Bashinski Shaefer, Benjamin McCullough, Hassan M. Fathallah‐Shaykh

Overview and significance 2.1.Classification of gliomas CNS neoplasms are diverse and demonstrate a great deal of variability in terms of clinical presentation, aggressiveness, and response to therapy, with distinctions in histology and cellular and molecular composition being primarily responsible for these variations …