Xiaolin L. Huang

Click-Chemistry-Enhanced Dynamic Light Scattering Immunoassay for Ultrasensitive GFAP Detection in Traumatic Brain Injury

Weipeng Tong, Hao Fang, Mingjian Yao, Ye Chen et autres

Traumatic brain injury (TBI) requires a rapid and objective assessment; however, current diagnostic methodologies are constrained by subjectivity, reliance on imaging techniques, and insufficient sensitivity for the early detection of biomarkers. In this study, we present a click-chemistry-enhanced dynamic light scattering (DLS) …

cn (code pays fourni par la source)

Engineered Bacteria-Driven Biohybrid Microrobots Potentiate IL-2 Immunotherapy by Evoking Pyroptosis

Ping Li, Qian Li, Lu Ding, Sujuan Peng et autres

Interleukin-2 (IL-2) immunotherapy offers considerable potential for metastatic cancers; however, its efficacy is limited by low response rates, dose-dependent toxicity, short half-life, poor tumor accumulation, and off-target immune activation. In this work, we present a biohybrid microrobot (IL-2@Z/C/A) engineered through biomimetic mineralization …

cn, us, kr (code pays fourni par la source)

G-Quadruplex-Enhanced DNA Silver Nanoclusters Enable CRISPR/Cas12a System for Ultrasensitive Detection of Salmonella typhimurium

Li Li, Yuanqian Xiong, Yuqian Guo, Hong Quan Duan et autres

DNA-templated silver nanoclusters (tDNA-AgNCs) show considerable promise as fluorescence reporters for the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system because of their ease of synthesis, strong resistance to photobleaching, and large Stokes shift. However, the weak luminous intensity and low …

cn (code pays fourni par la source)

CRISPR/Cas12a-Based Dynamic Light Scattering Assay for Nucleic Acid Amplification-Free and Ultrasensitive Detection of Listeria monocytogenes

Yuqian Guo, Yuanqian Xiong, Weipeng Tong, Xiaolin L. Huang

Ultrasensitive signal transduction systems are essential for developing rapid, robust, and sensitive nucleic acid tests using the amplification-free CRISPR-Cas12a system. In this study, we introduce a novel platform termed CRISPR-DART (dynamic light scattering Assisted Rapid Test), which combines CRISPR-Cas12a with a dynamic …

cn (code pays fourni par la source)

Ultrabright magneto-fluorescent nanoparticles-enhanced lateral flow immunoassay for ultrasensitive detection of Escherichia coli O157:H7

Xiaolong Wang, Yuhao Wu, Wenjing Li, Jiayi Sun et autres

cn (code pays fourni par la source)

Sprayable self-assembled curcumin-metal-polyphenol nanomedicine with anti-inflammatory, ROS-scavenging and pro-angiogenesis effects for promoting diabetic wound healing

Xiaodan Liang, Caihong Xian, Jiyuan Du, Xiaolin L. Huang et autres

Diabetes wounds present a complex microenvironment characterized by persistent inflammation, elevated reactive oxygen species (ROS), and compromised vascular conditions, all of which contribute to delayed or incomplete healing. Although advances in wound care have been made, effective strategies to address these multifaceted …

cn, hk (code pays fourni par la source)

DEM modeling of microstructural hardening and meso-flaw coupling driving crack propagation and acoustic emission in brittle rock

Xiaolin L. Huang, Cong Yin, Yuhang Zhang, Weiqi Kang et autres

cn, Rwanda, jp (code pays fourni par la source)

Metal-polyphenol network-coated aggregation-induced emission nanoprobes for enhanced lateral flow immunoassays

Xiaxia Wei, Fengxu Yu, Xiaolong Wang, Xirui Chen et autres

cn (code pays fourni par la source)

Aggregation-induced emission sparkles in immunoassay

Yu‐Xiong Su, Xiaojing Fan, Jiang Hu, Xiangmin Li et autres

cn, sa (code pays fourni par la source)

Twinkle Light‐Inspired Aggregation‐Induced Emission “Lighting‐Up” Bacteriophages to Enhance Immunoassays via Spontaneous Amino‐Yne Click Reaction

Xiaoyi Lv, Xirui Chen, Qi Chen, Qing Fei Liu et autres

ABSTRACT Traditional fluorescence immunoassays are often hindered by false negatives or quantification inaccuracies, especially at high target concentrations, due to the aggregation‐caused quenching effect of fluorescent indicators. This study introduces a novel fluorescence immunoassay strategy that leverages the spontaneous amino‐yne click reaction …

cn (code pays fourni par la source)

Bifunctional competitive antigen enhanced DLS Immunosensor for the ultrasensitive detection of furosemide in slimming products

Hao Fang, Huihui Chen, Qian Guo, Sicheng Xiong et autres

cn (code pays fourni par la source)

Distinct element modelling of stress wave propagation in rock masses considering asymmetrical loading/unloading behavior of filled fracture: Unique compression-hardening and memory effect

Jiahu Du, Xiaolin L. Huang, Han Bao, Weiqi Kang et autres

Dynamic loads like seismic and blasting waves, exhibit characteristics such as variable frequency, amplitude, and multiple cycles. These loads can induce cyclic loading and unloading of fractures in rock masses, progressively altering the mechanical properties of the fractures and affecting the propagation …

cn, Rwanda (code pays fourni par la source)