Srividya Ganapathy

Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells (Adv. Mater. 45/2026)

Marco Locarno, Qiangrui Dong, Marco Post, Xin Meng et autres

Plasmonic Gold nanostars act as plasmonic nanoantennas that couple to membrane proteins in living cells, simultaneously enhancing fluorescence and accelerating voltage responses of genetically encoded voltage indicators. By modifying protein photocycle dynamics through optical near fields, plasmonics emerges as a strategy to …

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Zebrafish Ace2N-mNeon expression toolkit for in vivo voltage imaging of neuronal synchrony and cardiac maturation

Zhenzhen Wu, Rui Oliveira Silva, Ruya Houssein, Fabiola Marques Trujillo et autres

Significance: Bioelectricity is a fundamental biophysical property of cells that shapes embryogenesis through neuronal signaling and tissue patterning. Yet techniques for cell-resolved, millisecond-scale voltage imaging in early embryos remain limited. Aim: To address this need, we developed a zebrafish expression toolkit for …

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Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells

Marco Locarno, Qiangrui Dong, Marco Post, Xin Meng et autres

This study shows that coupling to designed plasmonic nanoparticles can modulate the electrophysiological function of proteins in living mammalian cells. Nanostar-shaped particles, that are robust to biological noise, are designed to enable near-field-coupling to plasma membrane-localized mutated Archaerhodopsin proteins in live cells. …

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Silent emergence of Mycoplasma pneumonia from 2022 to 2024

Senthilraja Ramalingam, Srividya Ganapathy, Jayaswathi Kanchepalli, Mani Mariapppa

Objectives: Community-acquired pneumonia has been associated with increased morbidity and death, and it poses a serious threat to public health worldwide. Coughing and sneezing can spread aerosols of the Mycoplasma pneumoniae bacterium; infections are normally self-limiting and mild, but they may turn …

Unveiling a rare genetic aberration: A case study of Prader-Willi syndrome (PWS) with atypical 15q11.2-q13.3 deletion

Senthilraja Ramalingam, Srividya Ganapathy, Jayaswathi Kanchepalli, Vani Jayaraj et autres

Prader-Willi Syndrome (PWS) is a rare genetic disorder resulting from the absence of expression of genes in the 15q11–q13 region on the paternally derived chromosome 15. The present case report describes the chromosomal anomalies suspected to be present in a neonate, detected …

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Exploring Bioelectricity with Ace2N-mNeon during Zebrafish Embryogenesis

Zhenyang Wu, Ruya Houssein, Fabiola Marques Trujillo, Jordan Gotti et autres

Abstract Bioelectricity is a fundamental biophysical phenomenon present in all cells, playing a crucial role in embryogenesis by regulating processes such as neuronal signaling, pattern formation, and cancer suppression. Precise monitoring of bioelectric signals and their dynamic changes throughout development is vital …

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Plasmonic Enhancement of Protein Function

Marco Locarno, Qiangrui Dong, Xin Meng, Cristiano Glessi et autres

Plasmonic nanoparticles are key components in nanophotonics 1–11 and have applications in molecular detection and diagnostic platforms. 12–14 Coupling of dipoles to plasmonic antennas has allowed engineering of qualitatively altered behavior in isolated quantum systems, 8,15 but this promise has not been …

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Exposure to endocrine-disrupting metals and serum estrogen levels among US women

Anna Corry Gerald, Srividya Ganapathy, Jianmin Zhu, Yudan Wei

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Voltage Imaging with Engineered Proton-Pumping Rhodopsins: Insights from the Proton Transfer Pathway

Xin Meng, Srividya Ganapathy, Lars van Roemburg, Marco Post et autres

Voltage imaging using genetically encoded voltage indicators (GEVIs) has taken the field of neuroscience by storm in the past decade. Its ability to create subcellular and network level readouts of electrical dynamics depends critically on the kinetics of the response to voltage …

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Expanding the family of genetically encoded voltage indicators with a candidate Heliorhodopsin exhibiting near-infrared fluorescence

Srividya Ganapathy, Xin Meng, Delizzia Mossel, Mels Jagt et autres

Genetically encoded voltage indicators, particularly those based on microbial rhodopsins, are gaining traction in neuroscience as fluorescent sensors for imaging voltage dynamics with high-spatiotemporal precision. Here we establish a novel genetically encoded voltage indicator candidate based on the recently discovered subfamily of …

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Expanding the family of genetically encoded voltage indicators: Insights from heliorhodopsins

Srividya Ganapathy, Xin Meng, Delizzia Mossel, Mels Jagt et autres

Abstract Genetically encoded voltage indicators (GEVIs), particularly those based on microbial rhodopsins, are gaining traction in neuroscience as fluorescent sensors for imaging voltage dynamics with high-spatiotemporal precision. Here we establish a novel GEVI candidate based on the recently discovered subfamily of the …

us, nl (code pays fourni par la source)

Voltage imaging with engineered proton-pumping Rhodopsins: Insights from the proton transfer pathway

Xin Meng, Srividya Ganapathy, Lars van Roemburg, Marco Post et autres

Voltage imaging using genetically encoded voltage indicators (GEVI) has taken the field of neuroscience by storm in the past decade. Its ability to create subcellular and network level readouts of electrical dynamics depends critically on the kinetics of the response to voltage …

nl (code pays fourni par la source)