Daiana Vota

Altered IRE1α-Dependent Decidual Programming Links Impaired Inflammation and Angiogenesis in Recurrent Implantation Failure

Lara Castagnola, Lourdes Materazzi, Daniel Paparini, Ana Schafir et autres

Background: Decidualization alters the endometrial stromal cells (EnSC) secretome, allowing sterile inflammation associated with embryo implantation, but mechanisms that lead to alterations in this process are still unknown. We evaluated whether impaired IRE1α-mediated endoplasmic reticulum (ER) stress signalling contributes to defective angiogenic …

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Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes

Julieta Avalos, Florencia Sabbione, Daiana Rios, Daniel H. Grasso et autres

Introduction: Maternal immune adaptation during pregnancy is orchestrated by dynamic signals from the uterine microenvironment, including placental extracellular vesicles (pEVs) released into maternal circulation. EVs have emerged as key mediators of this crosstalk; however, their role in sex-specific immune modulation remains incompletely …

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Inflammatory and epigenetic alterations associated with attention deficits in adolescents with cocaine base paste addiction

Silvina V. Sonzogni, Laura Alethia de la Fuente, Camila Mimura, Agustina Aragón-Daud et autres

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Dynamic changes in neutrophil activation and metabolic profile during pregnancy are associated with gingival inflammation

Guillermina Calo, Fátima Merech, Florencia Sabbione, Luciana D’Eramo et autres

Neutrophils are key players in both periodontal and placental immunity, undergoing profound immunometabolic and functional changes during pregnancy. Their excessive activation has been linked to gestational complications. Gingivitis, and even more so periodontitis, the advanced stage of this condition, are chronic inflammatory …

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Editorial: Host-pathogen interactions during pregnancy: mechanisms of maternal and fetal immunity

Yael Alippe, Vanesa C. Hauk, Gil Mor, Daiana Vota

spontaneous abortion, preterm birth, and congenital abnormalities. Despite significant 5 progress, many aspects of immune responses during pregnancy and the mechanisms driving 6 infection-induced adverse outcomes remain unclear. This Research Topic provides novel 7 insights into these complex interactions, offering a deeper …

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P-629 Dysregulation of the immunometabolic profile in the aging human ovary

L Castagnola, María de Lourdes, A Schafir, Beatriz Lara et autres

Abstract Study question Is ovarian aging associated with the generation of inflammatory macrophages with a dysregulated immunometabolism and be ameliorated after treatment with platelet-rich plasma-releasate (PRPr)? Summary answer Aged follicular macrophages show an inflammatory profile associated with an altered metabolism that can …

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Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration

Elizabeth Soczewski, Ana Schafir, Lara Castagnola, Lourdes Materazzi et autres

Endometrial stromal cells acquire a secretory profile associated with endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) related to the onset of a sterile inflammatory response essential for sustaining embryo implantation. However, exacerbated stromal ERS/UPR is associated with reproductive complications. Given …

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Ovarian premature aging: VIP as key regulator of fibro-inflammation and foamy macrophages generation

Lara Castagnola, Lucila Gallino, Ana Schafir, Daiana Vota et autres

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Amyloid Beta Regulates Astrocytic Glucose Metabolism and Insulin Signaling in Experimental Models of Alzheimer’s Disease

Melisa Bentivegna, Carlos Javier Pomilio, Melina Bellotto, Nicolás González Pérez et autres

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by amyloid beta (Aβ) plaques, neuroinflammation and cognitive impairment. Metabolic disturbances, particularly brain insulin resistance, are increasingly recognized as central features of AD pathophysiology. Astrocytes, essential for brain energy metabolism, exhibit a …

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Pregnancy Entails a Metabolic Rewiring of Maternal Circulating Neutrophils

Guillermina Calo, Fátima Merech, Florencia Sabbione, Vanesa C. Hauk et autres

Immunometabolism is an emerging growing field that focuses on the role of cellular metabolism in the regulation of immune cell function and fate. Thus, proliferation, differentiation, activation, and function of immune cell populations are modulated by reprogramming their fueling and metabolic pathways. …

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Vasoactive intestinal peptide induces metabolic rewiring of human-derived cytotrophoblast cells to promote cell migration

Fátima Merech, Brenda Lara, Daiana Rios, Daniel Paparini et autres

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Sex-specific phenotypical, functional and metabolic profiles of human term placenta macrophages

Daniel Paparini, Esteban Grasso, Franco Aguilera, M. Agustina Arslanian et autres

BACKGROUND: Placental macrophages, Hofbauer cells (HBC) are the only fetal immune cell population within the stroma of healthy placenta along pregnancy. They are central players in maintaining immune tolerance during pregnancy. Immunometabolism emerged a few years ago as a new field that …

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