David P. Perrault

Dissolving Doubts: Resorbable Fixation in Posterior Vault Distraction Osteogenesis

Kirin Naidu, Zachary Zapatero, David P. Perrault, Isabel Ryan et autres

Posterior cranial vault distraction osteogenesis (PVDO) traditionally requires titanium screw fixation of metallic distractor footplates. Cho and colleagues recently described an off-label application of the Synthes RapidSorb Injectable Polymer System for footplate fixation in PVDO, reporting reduced distractor removal operative time in …

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Distraction in anterior plagiocephaly: technique, risks, and long-term results

Santiago Lopez-Becerra, David P. Perrault, Kirin Naidu, Maura R. Guyler et autres

PURPOSE: The purpose of this study is to define the perioperative outcomes and long-term aesthetic outcomes of patients with unicoronal craniosynostosis (UCS) treated with fronto-orbital distraction osteogenesis (FODO) and compare them to a contemporaneous cohort treated with conventional fronto-orbital advancement and remodeling …

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Spring-mediated cranioplasty for scaphocephaly: techniques and outcomes

Maura R. Guyler, David P. Perrault, Kirin Naidu, Santiago Lopez-Becerra et autres

PURPOSE: Spring-mediated cranioplasty (SMC) is an established minimally invasive technique for the treatment of sagittal craniosynostosis. This study describes our surgical technique and evaluates long-term morphometric outcomes following SMC. METHODS: A retrospective review was performed of subjects who underwent SMC as primary …

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The Challenge of Healing Wounds in Radiation-Injured Skin

Christopher V. Lavin, Carter B. Kendig, Danae Kawamoto, Jaden G Tarter et autres

SIGNIFICANCE: Wound healing in irradiated skin remains a clinical challenge, with radiation therapy (XRT) resulting in excess collagen deposition and cell death resulting in poor tissue quality. This frequently results in chronic wounds that compromise patient outcomes and quality of life. RECENT …

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Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis

Kellen Chen, Michelle Griffin, Dominic Henn, Katharina S. Berryman et autres

In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways in healing and fibrosis. However, tissue repair …

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A Treatment Algorithm for Patients with Lipedema

Kassandra Carrion, Nitya Devisetti, Lê Hùng Anh, Kelsey Jordan Lipman et autres

PURPOSE: Lipedema is a debilitating disease involving chronic accumulation of subcutaneous fat that is resistant to compression garments and lifestyle change. Lipedema affects approximately 19% of women. Past research has examined outcomes and patient satisfaction post liposuction for lipedema treatment at various …

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Assessing the Safety and Efficacy of Pediatric Nasal Surgery: A Systematic Review and Meta-Analysis

Raina Kushal Patel, Phillip Loan, Gabriela Cendejas, Maheen F. Akhter et autres

Pediatric nasal surgery has been controversial due to concerns about facial growth during adolescence. There is limited data on patient outcomes and no clear guidelines on the optimal age for surgery.To evaluate the safety, complication, and revision rates of nasal surgery in …

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Deferoxamine Intradermal Delivery Patch for Treatment of a Radiation Therapy Associated Breast Wound

David P. Perrault, Kellen Chen, Rahim S. Nazerali, Derrick C. Wan

Purpose: Radiation therapy is used in over 60% of cancer patients and can lead to radiation dermatitis, radiation induced fibrosis, hyperpigmentation, telangiectasias, fat necrosis, and poor wound healing. Deferoxamine (DFO) is an iron-chelating agent that has been used systemically to treat iron …

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Diagnosis and Management of Orbital Compartment Syndrome in Burn Patients—A Systematic Review

Nathan Makarewicz, David P. Perrault, Priscila C. Cevallos, Clifford Charles Sheckter

Orbital compartment syndrome is a poorly understood complication of acute burns. The purpose of this systematic review is to summarize the literature describing orbital compartment syndrome in patients with burns to provide greater detail on risk factors and guide the management of …

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79 Diagnosis and Management of Orbital Compartment Syndrome in Burn Patients —a Systematic Review

Nathan Makarewicz, David P. Perrault, Clifford Charles Sheckter

Abstract Introduction Orbital compartment syndrome (OCS) is a recognized yet poorly understood problem in the acute management of major burns. Proposed risk factors including large volume resuscitation and deep burns to the orbital region, though OCS has been described in less severe …

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Deferoxamine Intradermal Delivery Patch for Treatment of a Beta-Thalassemia Wound

David P. Perrault, Arhana Chattopadhyay, Dharshan Sivaraj, Derrick C. Wan et autres

MINI-ABSTRACT: In this study, we present the first-in-human use of topical deferoxamine (DFO) in the treatment of a beta-thalassemia wound. We elected to use DFO on a patient that suffered from a chronic nonhealing wound in the setting of beta-thalassemia. Despite approximately …

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Current Treatment Landscape for Dystrophic Epidermolysis Bullosa: From Surgical Management to Emerging Gene Therapies and Novel Skin Grafts

Dillan F. Villavisanis, David P. Perrault, Sara N. Kiani, David J. Cholok et autres

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