Yoshiaki Maru

Patient-Derived Organoids: Basic and Translational Research on Uterine Cancer

Yoshiaki Maru, Naotake Tanaka, Yoshitaka Hippo

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Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer

Yoshiaki Maru, Mami Kohno, Kiyomi Suzuka, Akiko Odaka et autres

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Bridging toxicological properties of environmental chemicals between animals and humans using healthy organoid systems

Toshio Imai, Rikako Ishigamori, Mie Naruse, Masako Ochiai et autres

The application of organoids derived from animal tissues and human-induced pluripotent stem cells to safety assessments of environmental chemicals has been introduced over the last decade. One of the objectives of this approach is to develop an alternative method for animal toxicological …

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Derivation of pancreatic acinar cell carcinoma cell line HS ‐1 as a patient‐derived tumor organoid

Daisuke Hoshi, Emiri Kita, Yoshiaki Maru, Hiroyuki Kogashi et autres

Acinar cell carcinoma (ACC) of the pancreas is a malignant tumor of the exocrine cell lineage with a poor prognosis. Due to its rare incidence and technical difficulties, few authentic human cell lines are currently available, hampering detailed investigations of ACC. Therefore, …

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Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells

Jihang Yao, Keizo Takenaga, Nobuko Koshikawa, Yuki Kida et autres

Cervical cancer remains a major threat to women's health, especially in countries with limited medical resources, and new drugs are needed to improve patient survival and minimize adverse effects. Here, we examine the effects of a triphenylphosphonium (TPP)-conjugated pyrrole-imidazole polyamide (CCC-h1005) targeting …

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The potential of organoids in toxicologic pathology: Histopathological and immunohistochemical evaluation of a mouse normal tissue-derived organoid-based carcinogenesis model

Rikako Ishigamori, Mie Naruse, Akihiro Hirata, Yoshiaki Maru et autres

Recently, we introduced an organoid-based chemical carcinogenesis model using mouse normal tissue-derived organoids. In the present review article, the histopathological and immunohistochemical characteristics of mouse normal tissue-derived organoids and tumors derived from these organoids after their in vitro treatment with genotoxic carcinogens …

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Two-Way Development of the Genetic Model for Endometrial Tumorigenesis in Mice: Current and Future Perspectives

Yoshiaki Maru, Yoshitaka Hippo

Endometrial cancer (EC) is the most common malignancy of the female reproductive tract worldwide. Although comprehensive genomic analyses of EC have already uncovered many recurrent genetic alterations and deregulated signaling pathways, its disease model has been limited in quantity and quality. Here, …

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Twists and turns in Kras-driven tumor initiation

Yoshiaki Maru, Yoshitaka Hippo

Accumulation of genetic mutations progressively drives carcinogenesis, which is affected by the cell lineage and organ-specific microenvironment.Reflecting the diversity in such cooperation, frequently mutated genes in cancer vary significantly according to the organ wherein carcinogenesis is initiated.Notably, a subset of cancers is …

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Probing the tumorigenic potential of genetic interactions reconstituted in murine fallopian tube organoids

Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura et autres

Genetically engineered mice have been the gold standard in modeling tumor development. Recent studies have demonstrated that genetically engineered organoids can develop subcutaneous tumors in immunocompromised mice, at least for organs that prefer predominant driver mutations for tumorigenesis. To further substantiate this …

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Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition

Yoshiaki Maru, Naotake Tanaka, Yasutoshi Tatsumi, Yuki Nakamura et autres

Abstract KRAS, an oncogene, is frequently activated by mutations in many cancers. Kras-driven adenocarcinoma development in the lung, pancreas, and biliary tract has been extensively studied using gene targeting in mice. By taking the organoid- and allograft-based genetic approach to these organs, …

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A case of cervical clear cell carcinoma with serous component

Keiko Ebisawa, Takahiro Sugiyama, Makiko Itami, Yoshiaki Maru et autres

Cervical clear cell carcinoma (CCCC) is rare. This report describes the case of CCCC with a serous component. A 22-year-old woman presented with vaginal bleeding. A cervical tumor was discovered: pelvic magnetic resonance imaging revealed a tumor measuring 46 mm. Radical hysterectomy …

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Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds

Shingo Kato, Kentaro Fushimi, Yuichiro Yabuki, Yoshiaki Maru et autres

Genetically engineered mice (GEM) are the gold standard for cancer modeling. However, strict recapitulation of stepwise carcinogenesis from a single tumor-initiating epithelial cell among genetically intact cells in adults is not feasible with the currently available techniques using GEM. In previous studies, …

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