Profil bibliographique

David Nicolas Debruyne

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

19Publications signalées
37Citations signalées
0Affiliations récentes

Les domaines associés

Cancer Research and TreatmentsCancer Cells and MetastasisNanoplatforms for cancer theranosticsMechanisms of cancer metastasisRNA Interference and Gene Delivery

Les publications récentes

Accès ouvert 2023 other OpenAlex

Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

Abstract There is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here, we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise from original differentiated tumor …

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

These figures describe that : dedifferentiation restores stem-like and tumorigenic properties (sup fig 5); EGFR and ERK inhibitions on the dedifferentiation process (sup fig 6 and 7).

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

The supplemental figure 12 describes EGR1 expression during cell dedifferentiation. The supplemental figure 13 descries miR-199a-3p conserved sites in EGR1 3'UTR. The supplemental figure 14 describes the effects of shEGR1 and synthetic miR-199a-3p on EGR1 and miR-199a-3p expression and the consequence on …

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

These figures describe egfr expression and amplification in the original tumors and patient-derived GSC (sup fig 1); spheroid formation (sup fig 2); magnification of figure 1b (sup fig 3), stem-like and tumorigenic properties of the resulting spheroids (sup fig 4).

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

These figures describe the identification of three clusters of genes that are regulated by ERK upon EGF-mediated dedifferentiation (sup fig 8) and the probability of survival of patients expressing these clusters at a level above or below the median of expression (sup …

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

The supplemental figure 10 describes the acquisition of pluripotency markers by tumor cells freshly dissociated from tumors at a single cell level. The supplemental figure 11 shows the ability of EGF, PDGF, bFGF to induce or not the dedifferentiation process.

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

These figures describe the identification of three clusters of genes that are regulated by ERK upon EGF-mediated dedifferentiation (sup fig 8) and the probability of survival of patients expressing these clusters at a level above or below the median of expression (sup …

0 citations
Accès ouvert 2023 supplementary-materials OpenAlex

Supplementary Data from ERK-Mediated Loss of miR-199a-3p and Induction of EGR1 Act as a “Toggle Switch” of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells

Fabien Almairac, Laurent Turchi, Nathalie Sakakini, David Nicolas Debruyne et autres

The supplemental figure 10 describes the acquisition of pluripotency markers by tumor cells freshly dissociated from tumors at a single cell level. The supplemental figure 11 shows the ability of EGF, PDGF, bFGF to induce or not the dedifferentiation process.

0 citations
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