Accès ouvert
2026
article
OpenAlex
David Mukunya, Daniel Mawanda, Rebecca Nantanda, Ruth Namazzi et autres
Background: Sickle cell disease (SCD) affects about 7.7 million people worldwide, and this has been increasing annually due to an increasing population in sub-Saharan Africa and the Caribbean. Pulmonary complications contribute significantly to mortality due to sickle cell disease. We have frequently …
Ouganda
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Anne Akullo, Cosmas Wamoto, Deogratias Munube, Joshua Muhumuza et autres
Abstract Background: In Sub Sahara Africa (SSA) where the burden of Sickle cell disease (SCD) is highest, newborn screening for SCD is not widely implemented. Most newborn screening efforts consist of centralized testing of samples collected from a geographically wide network of …
Ouganda, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Richard Idro, Bill Wambaka, Vincent Mboizi, Dennis Kalibbala et autres
Abstract Introduction: Children with sickle cell anemia (SCA) often develop cerebral vasculopathy early in life. Vascular injury is manifested by stroke, silent cerebral infarcts (SCI), arterial stenosis and elevated arterial flow velocity measured by transcranial doppler ultrasound (TCD). We had previously reported …
Ouganda, us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Russell E. Ware, Robert O. Opoka, Teresa Latham, Phillip Kasirye et autres
Abstract Introduction. Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM, NCT01976416) was a randomized placebo-controlled clinical trial of hydroxyurea for very young children with sickle cell anemia (SCA) living in Uganda. A total of 207 children with SCA (95 …
us, Kenya, Ouganda, ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Dennis Kalibbala, Vincent Mboizi, Grace Nambatya, Susan Murungi et autres
Children with sickle cell anaemia (SCA) in sub-Saharan Africa (SSA) frequently experience impaired growth. Hydroxyurea (hydroxycarbamide) improves growth in higher resourced countries, but its effects on growth and body composition have not been evaluated in SSA. In an open-label, single-arm, 30-month dose-escalated …
Ouganda, Kenya, Tanzanie, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Winnie Kibone, Conrad Muzoora, Felix Bongomin, Margaret Amelia Namiiro et autres
BACKGROUND: Sickle cell disease (SCD) is associated with significant mortality and morbidity, especially in low- and middle-income countries. OBJECTIVES: We determined the indications for hospitalisation and predictors of 30-day re-admission among patients with SCD in Northern and Central Uganda. DESIGN: Retrospective chart …
Ouganda, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Patience Birungi, Francis Xavier Kasujja, Aggrey Mukose, Phillip Kasirye et autres
Introduction: Worldwide sickle-cell disease has been identified as the most widespread genetic disorder highest in low-income countries. In Uganda, approximately 25,000 babies are born with sickle cell disease every year. Mulago National Referral Hospital runs the oldest and largest specialized sickle cell …
Ouganda
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Bill Wambaka, Amiirah Mpungu, Vincent Mboizi, Dennis Kalibbala et autres
INTRODUCTION: Transcranial Doppler ultrasound (TCD) screening for primary stroke prevention in children with sickle cell anemia (SCA) was established in higher-resource regions, targeting interventions for highest velocity ("abnormal"). We sought to identify additional stroke risk factors in Uganda. METHODS: We conducted a …
Ouganda, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shubaya Kasule Naggayi, Paul Bangirana, Robert O. Opoka, Simple Ouma et autres
INTRODUCTION: Academic proficiency is crucial for advancing learning goals, school advancement, and future economic security. Children with sickle cell anemia (SCA) in sub-Saharan Africa (SSA) may be at risk of disease-associated learning difficulties. Limited data exist on this topic among school-age children …
Ouganda, Kenya, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Bill Wambaka, Amiirah Mpungu, Vincent Mboizi, Dennis Kalibbala et autres
Introduction: Transcranial doppler ultrasound (TCD) screening for primary stroke prevention in children with sickle cell anemia (SCA) was established in higher-resource regions, targeting interventions for highest velocity ("abnormal"). We sought to identify additional stroke risk factors in Uganda. Methods: We conducted a …
Ouganda, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Vincent Mboizi, Catherine Nabaggala, Deogratias Munube, John M. Ssenkusu et autres
Background: Children with sickle cell anemia (SCA) in Sub-Saharan Africa are at high risk of sickle cerebrovascular injury (SCVI). Hydroxyurea, a commonly used disease-modifying therapy, may reduce SCVI resulting in potential impact on reducing stroke and cognitive dysfunction. We aim to test …
Ouganda, us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Bill Wambaka, Amiirah Mpungu, Vincent Mboizi, Dennis Kalibala et autres
Introduction Transcranial Doppler Ultrasound (TCD) screening for children with sickle cell anemia (SCA) was established in high-income regions for primary stroke prevention through targeted intervention for time-averaged mean velocity (TAMV) in the highest “abnormal” range. Additional stroke risk factors include severe anemia, …
Ouganda, Kenya, us
(code pays fourni par la source)