David Yiu Leung Chan

Multi-omics and developmental comparison of direct and conventional warming methods in vitrified human and mouse cleavage-stage embryos

Waner Wu, Yitong Shen, Shenghai Shen, Murong Xu et autres

STUDY QUESTION: Does direct warming preserve embryonic developmental competence and molecular integrity as well as conventional multi-step warming in vitrified human and mouse cleavage-stage embryos? SUMMARY ANSWER: Direct warming yielded comparable developmental and molecular outcomes to conventional warming in both mouse and …

hk, us (code pays fourni par la source)

Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences

S Wang, Jacqueline Pui Wah Chung, David Yiu Leung Chan

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are critical modulators of male reproductive health, influencing sperm function, hormonal regulation, and overall fertility. While physiological levels of ROS and RNS are essential for processes such as sperm capacitation and acrosome reaction, …

hk (code pays fourni par la source)

Sperm-Associated Mercury Species Levels Determine Its Impairment: Evidence from Paired Analyses of Whole Semen and Seminal Plasma

Mengwei Yuan, Martin Tsz‐Ki Tsui, Murong Xu, Chi Chiu Wang et autres

There have been conflicting results regarding the relationship between mercury (Hg) and semen quality among previous studies, partly because most studies rely on indirect reproductive biomarkers (e.g., whole blood, hair) and no study tested Hg species to understand their specific associations with …

hk, cn (code pays fourni par la source)

Direct warming and rehydration method in frozen embryo transfer: study protocol for a pragmatic, multi-center, double-blinded, two-arm randomized controlled trial

Waner Wu, Murong Xu, Ka Kei Fung, Linyao Zhang et autres

BACKGROUND: Embryo cryopreservation through vitrification is widely used to store surplus embryos for future transfer. Traditional multi-step warming methods are both time-consuming and costly. This study evaluates the clinical outcomes and the effectiveness of a novel direct warming method for frozen embryo …

hk (code pays fourni par la source)

Clinical outcomes and euploidy rates of embryos derived from zygotes with nonpronuclear (0PN) and monopronuclear (1PN) in IVF or ICSI cycles: a systematic review and meta-analysis

Hoi Wing Chan, Chi Chiu Wang, David Yiu Leung Chan

BACKGROUND: During routine fertilization checks, the presence of two pronuclei (2PN) with two polar bodies is generally regarded as normal fertilization. Nonpronuclear (0PN) zygotes often suggest failed fertilization, but some do cleave and develop into viable embryos due to delayed appearances of …

hk (code pays fourni par la source)

Combined nonoxynol-9 and antimicrobial peptide LL-37 for barrier contraception

Murong Xu, Carol Pui Shan Chan, Luping Cong, Jacqueline Pui Wah Chung et autres

Abstract: Birth control and sexually transmitted infections are global concerns. Nonoxynol-9 (N-9) is the most commonly used component in spermicides, with controversial safety and efficacy. LL-37 has been considered the most promising antimicrobial peptide for developing spermicides. Thus, we aimed to refine …

Underrecognized triploidy and genome-wide uniparental disomy in human blastocysts revealed by a concurrent preimplantation genetic testing approach

Ying Li, Matthew Hoi Kin Chau, Ying Xin Zhang, Bao Heng Gui et autres

STUDY QUESTION: What is the incidence of triploidy and genome-wide uniparental disomy (gwUPD) in human embryos currently undetected by conventional preimplantation genetic testing (PGT)? SUMMARY ANSWER: Triploidy and gwUPD were detected in 0.8% (8/1049) and 1.4% (15/1049) of blastocysts, respectively. WHAT IS …

cn, hk (code pays fourni par la source)

Enlarged Perivascular Spaces and Modifiable Vascular Risk Factors: Cross-Sectional and Longitudinal Analysis in the UK Biobank Cohort

Shizuka Hayashi, Jiyang Jiang, Song Yang, Matthew Paradise et autres

au (code pays fourni par la source)

Effectiveness and safety of time-lapse imaging for in vitro fertilisation: abridged secondary publication.

David Yiu Leung Chan, Tin Chiu Li, Jacqueline Pui Wah Chung, TL Lee et autres

hk, cn (code pays fourni par la source)

Sperm DNA fragmentation index did not associate with assisted reproductive outcomes: a cohort retrospective study of 5784 IVF/ICSI cycles

Tingfeng Fang, Yanhong Zhang, Wenchang Yu, Nengyong Ouyang et autres

cn, hk (code pays fourni par la source)

Time-lapse imaging systems for embryo incubation and assessment to improve reproductive outcomes in women undergoing in vitro fertilisation: study protocol for an individual participant data meta-analysis of randomised controlled trials

Priya Bhide, David Yiu Leung Chan, Aisling Ahlström, Laura del Campo-Albendea et autres

INTRODUCTION: Time-lapse imaging (TLI) systems for embryo incubation and assessment are hypothesised to improve the success rates of in vitro fertilisation (IVF) treatment by providing undisturbed culture conditions for embryos and/or providing more information on embryo development (morphokinetic parameters) to improve predictive …

gb, hk, se, es, nl, fr, tr (code pays fourni par la source)

Effect of Wuzi Yanzong on semen quality in subfertile men: a double-blind, randomised, placebo-controlled trial (abridged secondary publication).

Tin Chiu Li, Chi Chiu Wang, Zhi‐Xiu Lin, G W S Kong et autres

hk (code pays fourni par la source)