Irene Harder Tarpgaard

Immunological dysfunction associated with SARS-CoV-2 persistence in immunocompromised patients

I. Johannsen, Line K. Vibholm, Giacomo Schmidt Frattari, Míriam Rosás-Umbert et autres

Advances in coronavirus disease 2019 management has led to decreases in disease burden; however, immunocompromised patients continue to experience prolonged or persistent infections. We investigated immunological factors associated with time to viral clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

dk, au, ru (code pays fourni par la source)

Exploring the Immunological Factors Impacting SARS-CoV-2 Persistence in Patients with Secondary Immunodeficiencies

Line K. Vibholm, Giacomo Schmidt Frattari, Míriam Rosás-Umbert, Irene Harder Tarpgaard et autres

dk (code pays fourni par la source)

National guideline for verification of real-time PCR analyses for ISO 15189 accreditation in the field of clinical microbiology

Thomas Sundelin, Tina Vasehus Madsen, Marianne Nielsine Skov, Irene Harder Tarpgaard

dk, pl, ag (code pays fourni par la source)

Introduction and transmission of SARS-CoV-2 lineage B.1.1.7, Alpha variant, in Denmark

Thomas Yssing Michaelsen, Marc Bennedbæk, Lasse Engbo Christiansen, Mia S. F. Jørgensen et autres

BACKGROUND: In early 2021, the SARS-CoV-2 lineage B.1.1.7 (Alpha variant) became dominant across large parts of the world. In Denmark, comprehensive and real-time test, contact-tracing, and sequencing efforts were applied to sustain epidemic control. Here, we use these data to investigate the …

dk (code pays fourni par la source)

Increased transmissibility of SARS-CoV-2 lineage B.1.1.7 by age and viral load

Frederik Plesner Lyngse, Kåre Mølbak, Robert Leo Skov, Lasse Engbo Christiansen et autres

New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age …

dk (code pays fourni par la source)

Three cases of Sutterella wadsworthensis bacteremia secondary to abdominal infections

Karina Frahm Kirk, Kasper Lenni Andersen, Irene Harder Tarpgaard, Hans Linde Nielsen

The anaerobic bacterium Sutterella wadsworthensis has previously been isolated from the human intestine, both in healthy individuals and patients with gastrointestinal disorders, and the clinical significance of this bacterium is unknown. In this case report, we describe three cases of bacteremia with …

dk (code pays fourni par la source)

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

Ida Monrad, Signe Risgaard Sahlertz, Stine Sofie Frank Nielsen, Louise Ørnskov Pedersen et autres

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes …

dk (code pays fourni par la source)

Helicobacter cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient

Sofie Larsen Rasmussen, Iben Ørsted, Irene Harder Tarpgaard, Hans Linde Nielsen

BACKGROUND: Helicobacter cinaedi are motile, gram-negative spiral rods with a natural reservoir in the intestinal tract of hamsters and rhesus monkeys. In humans, H. cinaedi has been reported in different human infections like fever, abdominal pain, gastroenteritis, proctitis, diarrhoea, erysipelas, cellulitis, arthritis, …

dk (code pays fourni par la source)

First Danish case of infective endocarditis caused by Enterococcus hirae

Mette Winther, Michael Dalager‐Pedersen, Irene Harder Tarpgaard, Hans Linde Nielsen

Enterococcus hirae, a member of the Enterococcus genus, is known to cause infections, including infective endocarditis (IE), in animal species. In humans, E. hirae is an uncommon pathogen, but has been associated with severe and recurrent disease. Here, we report the first …

dk (code pays fourni par la source)

Case report: A fatal case of aortic and mitral valve endocarditis caused by Streptobacillus moniliformis

Mette Winther, Hanne Sortsøe Jensen, Irene Harder Tarpgaard, Hans Linde Nielsen

Abstract Background Infective endocarditis (IE) secondary to rat-bite fever (RBF) is rare but potentially lethal. Rapid diagnosis is of utmost prognostic importance. However, the diagnosis of RBF is challenging because Streptobacillus moniliformis does not grow under conventional culture conditions. Case summary A …

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Campylobacter concisus is prevalent in the gastrointestinal tract of patients with microscopic colitis

Marta Emilie Yde Aagaard, Karina Frahm Kirk, Hans Linde Nielsen, Irene Harder Tarpgaard et autres

Objectives Microscopic colitis (MC) is potentially induced by an inflammatory reaction to a luminal gut factor. The emerging pathogen Campylobacter concisus is associated with prolonged diarrhoea and subsequently increased risk of MC. We aimed to examine the prevalence of C. concisus in …

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Rare Elizabethkingia anophelis meningitis case in a Danish male

Hans Linde Nielsen, Irene Harder Tarpgaard, David Fuglsang-Damgaard, Philip Kjettinge Thomsen et autres

Introduction.Elizabethkingia anophelisis a Gram-negative, aerobic, non-motile rod belonging to the familyFlavobacteriaceae. Over the last 5 years, it has emerged as an opportunistic human pathogen involved in neonatal meningitis and sepsis, as well as nosocomial outbreaks. It has been isolated from the midgut …

dk, fr (code pays fourni par la source)