Jonathan Chernoff

Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer

Johnvesly Basappa, Cosimo Lobello, Anneliese M. Faustino, Cristina Uribe‐Alvarez et autres

ABSTRACT Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD⁺ salvage pathway, is frequently upregulated in cancer, yet mechanisms regulating its catalytic activity remain undefined. We identify NAMPT as a direct substrate of multiple proto-oncogenic tyrosine kinases, including ALK, insulin receptor, IGF1R, …

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Supplementary Figure 3 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

Daniela Araiza‐Olivera, Tatiana Y. Prudnikova, Cristina Uribe‐Alvarez, Kathy Q. Cai et autres

Figure S3. Drug-mediated wound healing assay.

Supplementary Figure 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

Daniela Araiza‐Olivera, Tatiana Y. Prudnikova, Cristina Uribe‐Alvarez, Kathy Q. Cai et autres

Figure S2. Chemical structures of the three key compounds.

Supplementary Table 2 from Identifying and Targeting Key Driver Genes for Collagen Production within the 11q13/14 Breast Cancer Amplicon

Daniela Araiza‐Olivera, Tatiana Y. Prudnikova, Cristina Uribe‐Alvarez, Kathy Q. Cai et autres

Table S2. IC50 Values of P4HA3 and SERPINH1 against IntClust-2 and non-IntClust-2 cell lines.

Determinación de la Cinasa CDK3 como Nuevo Sustrato de PTP1B y su importancia en la Progresión del Ciclo Celular en Células de Glioblastoma Humano Villamar-Cruz Olga*

Olga Villamar-Cruz, Luis E. Arias‐Romero, Jonathan Chernoff

Presentación en video de la participación en el 4o Congreso Anual Encuentro de Personas Técnicas Académicas de la UNAM.

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Determinación de la Cinasa CDK3 como Nuevo Sustrato de PTP1B y su importancia en la Progresión del Ciclo Celular en Células de Glioblastoma Humano Villamar-Cruz Olga*

Olga Villamar-Cruz, Luis E. Arias‐Romero, Jonathan Chernoff

Presentación en video de la participación en el 4o Congreso Anual Encuentro de Personas Técnicas Académicas de la UNAM.

mx, us (code pays fourni par la source)

Determinación de la Cinasa CDK3 como Nuevo Sustrato de PTP1B y su importancia en la Progresión del Ciclo Celular en Células de Glioblastoma Humano

Olga Villamar-Cruz, Luis E. Arias‐Romero, Jonathan Chernoff

Resumen en extenso de la participación en el 4o Congreso Anual Encuentro de Personas Técnicas Académicas de la UNAM

mx, us (code pays fourni par la source)

Determinación de la Cinasa CDK3 como Nuevo Sustrato de PTP1B y su importancia en la Progresión del Ciclo Celular en Células de Glioblastoma Humano

Olga Villamar-Cruz, Luis E. Arias‐Romero, Jonathan Chernoff

Resumen en extenso de la participación en el 4o Congreso Anual Encuentro de Personas Técnicas Académicas de la UNAM

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Abstract 4521: Use of a p120 RasGAP glue to inhibit KRas in NF1-null cells.

Anastasiia Gerasimova, Sven A. Miller, Jonathan Chernoff

Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that is associated with a spectrum of pathologies including glioma, autism spectrum disorder, Lisch nodules of the iris and neurofibroma. The NF1 gene encodes neurofibromin, a Ras GTPase-activating protein. Deletion or …

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CHK1/2 as a potential therapeutic target in Neurofibromatosis type 2 Schwannomas

Dorothy Benton, Ramil Khusnutdinov, Mariia Buts, Mariia Dmitrieva et autres

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PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement

Julie Drieu La Rochelle, Joseph P. Cassidy, Jonathan Chernoff, Ulla G. Knaus

Macrophages rely on dynamic cytoskeletal rearrangements to respond to their environment. This plasticity supports biomechanical transitions and functional polarization, mediating tissue homeostasis, antimicrobial defense, and repair processes. In the tumor environment context-specific reprogramming leads to functional diversification, from antitumorigenic to immunosuppressive phenotypes. …

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PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain

Yan Wang, Bokyung Kim, Xiangyi Shi, Huimin Chen et autres

Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual disability, neurodevelopmental abnormality, macrocephaly, and white matter anomaly in children. Oligodendroglial lineage cells undergo extensive proliferation and population expansion in human and rodent brain during early postnatal development. It remains unclear if and …

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